BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

198 related articles for article (PubMed ID: 28813011)

  • 1. Insights into the Effect of the G245S Single Point Mutation on the Structure of p53 and the Binding of the Protein to DNA.
    Lepre MG; Omar SI; Grasso G; Morbiducci U; Deriu MA; Tuszynski JA
    Molecules; 2017 Aug; 22(8):. PubMed ID: 28813011
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dynamic perspectives into the mechanisms of mutation-induced p53-DNA binding loss and inactivation using active perturbation theory: Structural and molecular insights toward the design of potent reactivators in cancer therapy.
    Olotu FA; Soliman MES
    J Cell Biochem; 2019 Jan; 120(1):951-966. PubMed ID: 30160791
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Virtual screening using covalent docking to find activators for G245S mutant p53.
    Omar SI; Lepre MG; Morbiducci U; Deriu MA; Tuszynski JA
    PLoS One; 2018; 13(9):e0200769. PubMed ID: 30192754
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations.
    Suad O; Rozenberg H; Brosh R; Diskin-Posner Y; Kessler N; Shimon LJ; Frolow F; Liran A; Rotter V; Shakked Z
    J Mol Biol; 2009 Jan; 385(1):249-65. PubMed ID: 18996393
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Hot-spot mutants of p53 core domain evince characteristic local structural changes.
    Wong KB; DeDecker BS; Freund SM; Proctor MR; Bycroft M; Fersht AR
    Proc Natl Acad Sci U S A; 1999 Jul; 96(15):8438-42. PubMed ID: 10411893
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Dynamics and Molecular Mechanisms of p53 Transcriptional Activation.
    Offutt TL; Ieong PU; Demir Ö; Amaro RE
    Biochemistry; 2018 Nov; 57(46):6528-6537. PubMed ID: 30388364
    [TBL] [Abstract][Full Text] [Related]  

  • 7. QM-MM simulations on p53-DNA complex: a study of hot spot and rescue mutants.
    Koulgi S; Achalere A; Sharma N; Sonavane U; Joshi R
    J Mol Model; 2013 Dec; 19(12):5545-59. PubMed ID: 24253321
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations.
    Nikolova PV; Wong KB; DeDecker B; Henckel J; Fersht AR
    EMBO J; 2000 Feb; 19(3):370-8. PubMed ID: 10654936
    [TBL] [Abstract][Full Text] [Related]  

  • 9. p53 mutants G245S and R337H associated with the Li-Fraumeni syndrome regulate distinct metabolic pathways.
    Meneghetti BV; Wilson R; Dias CK; Cadore NA; Klamt F; Zaha A; Ferreira HB; Monteiro KM
    Biochimie; 2022 Jul; 198():141-154. PubMed ID: 35367578
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Specific DNA binding by different classes of human p53 mutants.
    Rolley N; Butcher S; Milner J
    Oncogene; 1995 Aug; 11(4):763-70. PubMed ID: 7651740
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.
    Sigal A; Rotter V
    Cancer Res; 2000 Dec; 60(24):6788-93. PubMed ID: 11156366
    [TBL] [Abstract][Full Text] [Related]  

  • 12. How many mutant p53 molecules are needed to inactivate a tetramer?
    Chan WM; Siu WY; Lau A; Poon RY
    Mol Cell Biol; 2004 Apr; 24(8):3536-51. PubMed ID: 15060172
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Factors governing loss and rescue of DNA binding upon single and double mutations in the p53 core domain.
    Wright JD; Noskov SY; Lim C
    Nucleic Acids Res; 2002 Apr; 30(7):1563-74. PubMed ID: 11917017
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural effects of the L145Q, V157F, and R282W cancer-associated mutations in the p53 DNA-binding core domain.
    Calhoun S; Daggett V
    Biochemistry; 2011 Jun; 50(23):5345-53. PubMed ID: 21561095
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy.
    Bullock AN; Henckel J; Fersht AR
    Oncogene; 2000 Mar; 19(10):1245-56. PubMed ID: 10713666
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Restoration of the transcription activation function to mutant p53 in human cancer cells.
    Abarzúa P; LoSardo JE; Gubler ML; Spathis R; Lu YA; Felix A; Neri A
    Oncogene; 1996 Dec; 13(11):2477-82. PubMed ID: 8957091
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Unraveling the Structural Changes in the DNA-Binding Region of Tumor Protein p53 (
    Balasundaram A; Doss CGP
    Int J Mol Sci; 2022 Dec; 23(24):. PubMed ID: 36555140
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Specific binding of MAR/SAR DNA-elements by mutant p53.
    Müller BF; Paulsen D; Deppert W
    Oncogene; 1996 May; 12(9):1941-52. PubMed ID: 8649855
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Distinct TP53 Mutation Types Exhibit Increased Sensitivity to Ferroptosis Independently of Changes in Iron Regulatory Protein Activity.
    Thompson LR; Oliveira TG; Hermann ER; Chowanadisai W; Clarke SL; Montgomery MR
    Int J Mol Sci; 2020 Sep; 21(18):. PubMed ID: 32942535
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53.
    Ohnishi T; Ohnishi K; Takahashi A
    BMC Biotechnol; 2002 Apr; 2():6. PubMed ID: 11965244
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.