231 related articles for article (PubMed ID: 28830713)
1. Characterization of loperamide-mediated block of hERG channels at physiological temperature and its proarrhythmia propensity.
Sheng J; Tran PN; Li Z; Dutta S; Chang K; Colatsky T; Wu WW
J Pharmacol Toxicol Methods; 2017; 88(Pt 2):109-122. PubMed ID: 28830713
[TBL] [Abstract][Full Text] [Related]
2. Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic.
Kang J; Compton DR; Vaz RJ; Rampe D
Naunyn Schmiedebergs Arch Pharmacol; 2016 Oct; 389(10):1133-7. PubMed ID: 27530870
[TBL] [Abstract][Full Text] [Related]
3. Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.
Davie C; Pierre-Valentin J; Pollard C; Standen N; Mitcheson J; Alexander P; Thong B
J Cardiovasc Electrophysiol; 2004 Nov; 15(11):1302-9. PubMed ID: 15574182
[TBL] [Abstract][Full Text] [Related]
4. Potent Inhibition of hERG Channels by the Over-the-Counter Antidiarrheal Agent Loperamide.
Klein MG; Haigney MCP; Mehler PS; Fatima N; Flagg TP; Krantz MJ
JACC Clin Electrophysiol; 2016 Dec; 2(7):784-789. PubMed ID: 29759761
[TBL] [Abstract][Full Text] [Related]
5. Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide.
Milnes JT; Witchel HJ; Leaney JL; Leishman DJ; Hancox JC
J Pharmacol Toxicol Methods; 2010; 61(2):178-91. PubMed ID: 20172036
[TBL] [Abstract][Full Text] [Related]
6. The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose.
Lu HR; Damiano BP; Kreir M; Rohrbacher J; van der Linde H; Saidov T; Teisman A; Gallacher DJ
Biomolecules; 2023 Sep; 13(9):. PubMed ID: 37759755
[TBL] [Abstract][Full Text] [Related]
7. An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel.
Crumb WJ; Vicente J; Johannesen L; Strauss DG
J Pharmacol Toxicol Methods; 2016; 81():251-62. PubMed ID: 27060526
[TBL] [Abstract][Full Text] [Related]
8. Quantitative Profiling of the Effects of Vanoxerine on Human Cardiac Ion Channels and its Application to Cardiac Risk.
Obejero-Paz CA; Bruening-Wright A; Kramer J; Hawryluk P; Tatalovic M; Dittrich HC; Brown AM
Sci Rep; 2015 Nov; 5():17623. PubMed ID: 26616666
[TBL] [Abstract][Full Text] [Related]
9. State dependent dissociation of HERG channel inhibitors.
Stork D; Timin EN; Berjukow S; Huber C; Hohaus A; Auer M; Hering S
Br J Pharmacol; 2007 Aug; 151(8):1368-76. PubMed ID: 17592502
[TBL] [Abstract][Full Text] [Related]
10. Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells.
Jehle J; Ficker E; Wan X; Deschenes I; Kisselbach J; Wiedmann F; Staudacher I; Schmidt C; Schweizer PA; Becker R; Katus HA; Thomas D
Br J Pharmacol; 2013 Mar; 168(5):1215-29. PubMed ID: 23061993
[TBL] [Abstract][Full Text] [Related]
11. Improving the In Silico Assessment of Proarrhythmia Risk by Combining hERG (Human Ether-à-go-go-Related Gene) Channel-Drug Binding Kinetics and Multichannel Pharmacology.
Li Z; Dutta S; Sheng J; Tran PN; Wu W; Chang K; Mdluli T; Strauss DG; Colatsky T
Circ Arrhythm Electrophysiol; 2017 Feb; 10(2):e004628. PubMed ID: 28202629
[TBL] [Abstract][Full Text] [Related]
12. A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel.
Li Z; Dutta S; Sheng J; Tran PN; Wu W; Colatsky T
J Pharmacol Toxicol Methods; 2016; 81():233-9. PubMed ID: 27178106
[TBL] [Abstract][Full Text] [Related]
13. Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration.
Hong HK; Lee BH; Park MH; Lee SH; Chu D; Kim WJ; Choe H; Hee Choi B; Jo SH
Eur J Pharmacol; 2013 Feb; 702(1-3):165-73. PubMed ID: 23395964
[TBL] [Abstract][Full Text] [Related]
14. The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o.
Diaz GJ; Daniell K; Leitza ST; Martin RL; Su Z; McDermott JS; Cox BF; Gintant GA
J Pharmacol Toxicol Methods; 2004; 50(3):187-99. PubMed ID: 15519905
[TBL] [Abstract][Full Text] [Related]
15. Molecular interaction of droperidol with human ether-a-go-go-related gene channels: prolongation of action potential duration without inducing early afterdepolarization.
Schwoerer AP; Blütner C; Brandt S; Binder S; Siebrands CC; Ehmke H; Friederich P
Anesthesiology; 2007 May; 106(5):967-76. PubMed ID: 17457128
[TBL] [Abstract][Full Text] [Related]
16. 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-related gene potassium channels.
Gordon E; Lozinskaya IM; Lin Z; Semus SF; Blaney FE; Willette RN; Xu X
Mol Pharmacol; 2008 Mar; 73(3):639-51. PubMed ID: 18042732
[TBL] [Abstract][Full Text] [Related]
17. H(1) antihistamine drug promethazine directly blocks hERG K(+) channel.
Jo SH; Hong HK; Chong SH; Lee HS; Choe H
Pharmacol Res; 2009 Nov; 60(5):429-37. PubMed ID: 19497368
[TBL] [Abstract][Full Text] [Related]
18. Action potential experiments complete hERG assay and QT-interval measurements in cardiac preclinical studies.
Ducroq J; Printemps R; Guilbot S; Gardette J; Salvetat C; Le Grand M
J Pharmacol Toxicol Methods; 2007; 56(2):159-70. PubMed ID: 17604185
[TBL] [Abstract][Full Text] [Related]
19. Blockade of HERG human K+ channel and IKr of guinea pig cardiomyocytes by prochlorperazine.
Kim MD; Eun SY; Jo SH
Eur J Pharmacol; 2006 Aug; 544(1-3):82-90. PubMed ID: 16860311
[TBL] [Abstract][Full Text] [Related]
20. Cardiac voltage-gated ion channels in safety pharmacology: Review of the landscape leading to the CiPA initiative.
Huang H; Pugsley MK; Fermini B; Curtis MJ; Koerner J; Accardi M; Authier S
J Pharmacol Toxicol Methods; 2017 Sep; 87():11-23. PubMed ID: 28408211
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]