BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

397 related articles for article (PubMed ID: 28853884)

  • 21. Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex.
    Miller F; Kentsis A; Osman R; Pan ZQ
    J Biol Chem; 2005 Mar; 280(9):7985-96. PubMed ID: 15611064
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer.
    Maynard MA; Ohh M
    Am J Nephrol; 2004; 24(1):1-13. PubMed ID: 14654728
    [TBL] [Abstract][Full Text] [Related]  

  • 23. HIF-1alpha and EPAS ubiquitination mediated by the VHL tumour suppressor involves flexibility in the ubiquitination mechanism, similar to other RING E3 ligases.
    Paltoglou S; Roberts BJ
    Oncogene; 2007 Jan; 26(4):604-9. PubMed ID: 16862177
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Hydroxylation-Dependent Interaction of Substrates to the Von Hippel-Lindau Tumor Suppressor Protein (VHL).
    Heir P; Ohh M
    Methods Mol Biol; 2016; 1458():87-94. PubMed ID: 27581016
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7.
    Zoppi V; Hughes SJ; Maniaci C; Testa A; Gmaschitz T; Wieshofer C; Koegl M; Riching KM; Daniels DL; Spallarossa A; Ciulli A
    J Med Chem; 2019 Jan; 62(2):699-726. PubMed ID: 30540463
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha.
    Kong X; Lin Z; Liang D; Fath D; Sang N; Caro J
    Mol Cell Biol; 2006 Mar; 26(6):2019-28. PubMed ID: 16507982
    [TBL] [Abstract][Full Text] [Related]  

  • 27. HIF-1α Hydroxyprolines Modulate Oxygen-Dependent Protein Stability Via Single VHL Interface With Comparable Effect on Ubiquitination Rate.
    He W; Batty-Stuart S; Lee JE; Ohh M
    J Mol Biol; 2021 Nov; 433(22):167244. PubMed ID: 34537235
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity.
    Hansen WJ; Ohh M; Moslehi J; Kondo K; Kaelin WG; Welch WJ
    Mol Cell Biol; 2002 Mar; 22(6):1947-60. PubMed ID: 11865071
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Leu-574 of HIF-1alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway.
    Huang LE; Pete EA; Schau M; Milligan J; Gu J
    J Biol Chem; 2002 Nov; 277(44):41750-5. PubMed ID: 12205091
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition.
    Chintala S; Najrana T; Toth K; Cao S; Durrani FA; Pili R; Rustum YM
    BMC Cancer; 2012 Jul; 12():293. PubMed ID: 22804960
    [TBL] [Abstract][Full Text] [Related]  

  • 31. VHL-based PROTACs as potential therapeutic agents: Recent progress and perspectives.
    Wang C; Zhang Y; Wang J; Xing D
    Eur J Med Chem; 2022 Jan; 227():113906. PubMed ID: 34656901
    [TBL] [Abstract][Full Text] [Related]  

  • 32. The VHL tumor suppressor: master regulator of HIF.
    Haase VH
    Curr Pharm Des; 2009; 15(33):3895-903. PubMed ID: 19671042
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Potent and Selective Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2) Heterobifunctional Small-molecule Degraders.
    Hu J; Wei J; Yim H; Wang L; Xie L; Jin MS; Kabir M; Qin L; Chen X; Liu J; Jin J
    J Med Chem; 2020 Dec; 63(24):15883-15905. PubMed ID: 33284613
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Expression of HIF-1 and ubiquitin in conventional renal cell carcinoma: relationship to mutations of the von Hippel-Lindau tumor suppressor gene.
    Hughson MD; He Z; Liu S; Coleman J; Shingleton WB
    Cancer Genet Cytogenet; 2003 Jun; 143(2):145-53. PubMed ID: 12781449
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Phosphorylation of the von Hippel-Lindau protein (VHL) by protein kinase CK2 reduces its protein stability and affects p53 and HIF-1alpha mediated transcription.
    Ampofo E; Kietzmann T; Zimmer A; Jakupovic M; Montenarh M; Götz C
    Int J Biochem Cell Biol; 2010 Oct; 42(10):1729-35. PubMed ID: 20637892
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein.
    Tanimoto K; Makino Y; Pereira T; Poellinger L
    EMBO J; 2000 Aug; 19(16):4298-309. PubMed ID: 10944113
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.
    Krieg M; Haas R; Brauch H; Acker T; Flamme I; Plate KH
    Oncogene; 2000 Nov; 19(48):5435-43. PubMed ID: 11114720
    [TBL] [Abstract][Full Text] [Related]  

  • 38. The interaction of the von Hippel-Lindau tumor suppressor and heterochromatin protein 1.
    Lai Y; Song M; Hakala K; Weintraub ST; Shiio Y
    Arch Biochem Biophys; 2012 Feb; 518(2):103-10. PubMed ID: 22234250
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Renal cell carcinoma risk in type 2 von Hippel-Lindau disease correlates with defects in pVHL stability and HIF-1alpha interactions.
    Knauth K; Bex C; Jemth P; Buchberger A
    Oncogene; 2006 Jan; 25(3):370-7. PubMed ID: 16261165
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Molecular cloning and characterization of the von Hippel-Lindau-like protein.
    Qi H; Gervais ML; Li W; DeCaprio JA; Challis JR; Ohh M
    Mol Cancer Res; 2004 Jan; 2(1):43-52. PubMed ID: 14757845
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 20.