308 related articles for article (PubMed ID: 28855340)
21. Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases.
Lynch CJ; Bernad R; Martínez-Val A; Shahbazi MN; Nóbrega-Pereira S; Calvo I; Blanco-Aparicio C; Tarantino C; Garreta E; Richart-Ginés L; Alcazar N; Graña-Castro O; Gómez-Lopez G; Aksoy I; Muñoz-Martín M; Martinez S; Ortega S; Prieto S; Simboeck E; Camasses A; Stephan-Otto Attolini C; Fernandez AF; Sierra MI; Fraga MF; Pastor J; Fisher D; Montserrat N; Savatier P; Muñoz J; Zernicka-Goetz M; Serrano M
Nat Cell Biol; 2020 Oct; 22(10):1223-1238. PubMed ID: 32989249
[TBL] [Abstract][Full Text] [Related]
22. HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.
Galbraith MD; Allen MA; Bensard CL; Wang X; Schwinn MK; Qin B; Long HW; Daniels DL; Hahn WC; Dowell RD; Espinosa JM
Cell; 2013 Jun; 153(6):1327-39. PubMed ID: 23746844
[TBL] [Abstract][Full Text] [Related]
23. Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.
Offermann A; Joerg V; Becker F; Roesch MC; Kang D; Lemster AL; Tharun L; Behrends J; Merseburger AS; Culig Z; Sailer V; Brägelmann J; Kirfel J; Perner S
Am J Pathol; 2022 May; 192(5):813-823. PubMed ID: 35181333
[TBL] [Abstract][Full Text] [Related]
24. The two faces of Cdk8, a positive/negative regulator of transcription.
Nemet J; Jelicic B; Rubelj I; Sopta M
Biochimie; 2014 Feb; 97():22-7. PubMed ID: 24139904
[TBL] [Abstract][Full Text] [Related]
25. Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy?
Philip S; Kumarasiri M; Teo T; Yu M; Wang S
J Med Chem; 2018 Jun; 61(12):5073-5092. PubMed ID: 29266937
[TBL] [Abstract][Full Text] [Related]
26. MED12 interacts with the heat-shock transcription factor HSF1 and recruits CDK8 to promote the heat-shock response in mammalian cells.
Srivastava P; Takii R; Okada M; Fujimoto M; Nakai A
FEBS Lett; 2021 Jul; 595(14):1933-1948. PubMed ID: 34056708
[TBL] [Abstract][Full Text] [Related]
27. Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation.
Belakavadi M; Fondell JD
Mol Cell Biol; 2010 May; 30(10):2437-48. PubMed ID: 20231357
[TBL] [Abstract][Full Text] [Related]
28. Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance.
Hofmann MH; Mani R; Engelhardt H; Impagnatiello MA; Carotta S; Kerenyi M; Lorenzo-Herrero S; Böttcher J; Scharn D; Arnhof H; Zoephel A; Schnitzer R; Gerstberger T; Sanderson MP; Rajgolikar G; Goswami S; Vasu S; Ettmayer P; Gonzalez S; Pearson M; McConnell DB; Kraut N; Muthusamy N; Moll J
Mol Cancer Ther; 2020 Apr; 19(4):1018-1030. PubMed ID: 32024684
[TBL] [Abstract][Full Text] [Related]
29. Regulatory functions of the Mediator kinases CDK8 and CDK19.
Fant CB; Taatjes DJ
Transcription; 2019 Apr; 10(2):76-90. PubMed ID: 30585107
[TBL] [Abstract][Full Text] [Related]
30. Identifying Cancers Impacted by CDK8/19.
Roninson IB; Győrffy B; Mack ZT; Shtil AA; Shtutman MS; Chen M; Broude EV
Cells; 2019 Aug; 8(8):. PubMed ID: 31382571
[TBL] [Abstract][Full Text] [Related]
31. Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.
Brägelmann J; Klümper N; Offermann A; von Mässenhausen A; Böhm D; Deng M; Queisser A; Sanders C; Syring I; Merseburger AS; Vogel W; Sievers E; Vlasic I; Carlsson J; Andrén O; Brossart P; Duensing S; Svensson MA; Adler D; Kirfel J; Perner S
Clin Cancer Res; 2017 Apr; 23(7):1829-1840. PubMed ID: 27678455
[No Abstract] [Full Text] [Related]
32. Mediator kinase inhibition further activates super-enhancer-associated genes in AML.
Pelish HE; Liau BB; Nitulescu II; Tangpeerachaikul A; Poss ZC; Da Silva DH; Caruso BT; Arefolov A; Fadeyi O; Christie AL; Du K; Banka D; Schneider EV; Jestel A; Zou G; Si C; Ebmeier CC; Bronson RT; Krivtsov AV; Myers AG; Kohl NE; Kung AL; Armstrong SA; Lemieux ME; Taatjes DJ; Shair MD
Nature; 2015 Oct; 526(7572):273-276. PubMed ID: 26416749
[TBL] [Abstract][Full Text] [Related]
33. Cyclin C influences the timing of mitosis in fission yeast.
Banyai G; Szilagyi Z; Baraznenok V; Khorosjutina O; Gustafsson CM
Mol Biol Cell; 2017 Jul; 28(13):1738-1744. PubMed ID: 28515143
[TBL] [Abstract][Full Text] [Related]
34. Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19.
Bernad R; Lynch CJ; Urdinguio RG; Stephan-Otto Attolini C; Fraga MF; Serrano M
Cells; 2021 Apr; 10(4):. PubMed ID: 33921436
[TBL] [Abstract][Full Text] [Related]
35. Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential.
Fujimoto J; Hirayama T; Hirata Y; Hikichi Y; Murai S; Hasegawa M; Hasegawa Y; Yonemori K; Hata A; Aoyama K; Cary DR
Bioorg Med Chem; 2017 Jun; 25(12):3018-3033. PubMed ID: 28392276
[TBL] [Abstract][Full Text] [Related]
36. Discovery of a Novel and Potent Cyclin-Dependent Kinase 8/19 (CDK8/19) Inhibitor for the Treatment of Cancer.
Xu J; Qi H; Wang Z; Wang L; Steurer B; Cai X; Liu J; Aliper A; Zhang M; Ren F; Zhavoronkov A; Ding X
J Med Chem; 2024 May; 67(10):8161-8171. PubMed ID: 38690856
[TBL] [Abstract][Full Text] [Related]
37. Inhibition of Cdk8/Cdk19 Activity Promotes Treg Cell Differentiation and Suppresses Autoimmune Diseases.
Guo Z; Wang G; Lv Y; Wan YY; Zheng J
Front Immunol; 2019; 10():1988. PubMed ID: 31552016
[TBL] [Abstract][Full Text] [Related]
38. Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila.
Liao JZ; Chung HL; Shih C; Wong KKL; Dutta D; Nil Z; Burns CG; Kanca O; Park YJ; Zuo Z; Marcogliese PC; Sew K; Bellen HJ; Verheyen EM
Nat Commun; 2024 Apr; 15(1):3326. PubMed ID: 38637532
[TBL] [Abstract][Full Text] [Related]
39. MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase.
Sooraj D; Sun C; Doan A; Garama DJ; Dannappel MV; Zhu D; Chua HK; Mahara S; Wan Hassan WA; Tay YK; Guanizo A; Croagh D; Prodanovic Z; Gough DJ; Wan C; Firestein R
Mol Cell; 2022 Jan; 82(1):123-139.e7. PubMed ID: 34910943
[TBL] [Abstract][Full Text] [Related]
40. CDK8 is a stimulus-specific positive coregulator of p53 target genes.
Donner AJ; Szostek S; Hoover JM; Espinosa JM
Mol Cell; 2007 Jul; 27(1):121-33. PubMed ID: 17612495
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]