BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

320 related articles for article (PubMed ID: 28872463)

  • 1. mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy.
    Bartolomeo R; Cinque L; De Leonibus C; Forrester A; Salzano AC; Monfregola J; De Gennaro E; Nusco E; Azario I; Lanzara C; Serafini M; Levine B; Ballabio A; Settembre C
    J Clin Invest; 2017 Oct; 127(10):3717-3729. PubMed ID: 28872463
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner.
    Newton PT; Vuppalapati KK; Bouderlique T; Chagin AS
    Autophagy; 2015; 11(9):1594-607. PubMed ID: 26259639
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Defective collagen proteostasis and matrix formation in the pathogenesis of lysosomal storage disorders.
    Settembre C; Cinque L; Bartolomeo R; Di Malta C; De Leonibus C; Forrester A
    Matrix Biol; 2018 Oct; 71-72():283-293. PubMed ID: 29870768
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling.
    Chen Y; Wei H; Liu F; Guan JL
    J Biol Chem; 2014 Jan; 289(2):1164-73. PubMed ID: 24275666
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells.
    Aryal P; Kim K; Park PH; Ham S; Cho J; Song K
    FEBS J; 2014 Oct; 281(20):4644-58. PubMed ID: 25132405
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice.
    Khayati K; Antikainen H; Bonder EM; Weber GF; Kruger WD; Jakubowski H; Dobrowolski R
    FASEB J; 2017 Feb; 31(2):598-609. PubMed ID: 28148781
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Autophagy, lipophagy and lysosomal lipid storage disorders.
    Ward C; Martinez-Lopez N; Otten EG; Carroll B; Maetzel D; Singh R; Sarkar S; Korolchuk VI
    Biochim Biophys Acta; 2016 Apr; 1861(4):269-84. PubMed ID: 26778751
    [TBL] [Abstract][Full Text] [Related]  

  • 8. mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis.
    Chen J; Long F
    Development; 2014 Jul; 141(14):2848-54. PubMed ID: 24948603
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis.
    Pan H; Zhong XP; Lee S
    BMC Biochem; 2016 Jul; 17(1):14. PubMed ID: 27387347
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inflammasome, mTORC1 activation, and metabolic derangement contribute to the susceptibility of diabetics to infections.
    Krakauer T
    Med Hypotheses; 2015 Dec; 85(6):997-1001. PubMed ID: 26384528
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Combined regulation of mTORC1 and lysosomal acidification by GSK-3 suppresses autophagy and contributes to cancer cell growth.
    Azoulay-Alfaguter I; Elya R; Avrahami L; Katz A; Eldar-Finkelman H
    Oncogene; 2015 Aug; 34(35):4613-23. PubMed ID: 25500539
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Diminished MTORC1-Dependent JNK Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction.
    Wong CO; Palmieri M; Li J; Akhmedov D; Chao Y; Broadhead GT; Zhu MX; Berdeaux R; Collins CA; Sardiello M; Venkatachalam K
    Cell Rep; 2015 Sep; 12(12):2009-20. PubMed ID: 26387958
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice.
    Tanaka Y; Matsuwaki T; Yamanouchi K; Nishihara M
    Neuroscience; 2013 Oct; 250():8-19. PubMed ID: 23830905
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The lysosome: a crucial hub for AMPK and mTORC1 signalling.
    Carroll B; Dunlop EA
    Biochem J; 2017 Apr; 474(9):1453-1466. PubMed ID: 28408430
    [TBL] [Abstract][Full Text] [Related]  

  • 15. mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis.
    Wan W; You Z; Xu Y; Zhou L; Guan Z; Peng C; Wong CCL; Su H; Zhou T; Xia H; Liu W
    Mol Cell; 2017 Oct; 68(2):323-335.e6. PubMed ID: 29033323
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The amino acid transporter SLC38A9 regulates MTORC1 and autophagy.
    Jin M; Klionsky DJ
    Autophagy; 2015; 11(10):1709-10. PubMed ID: 26506891
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Electroacupuncture protects against ischemic stroke by reducing autophagosome formation and inhibiting autophagy through the mTORC1-ULK1 complex-Beclin1 pathway.
    Liu W; Shang G; Yang S; Huang J; Xue X; Lin Y; Zheng Y; Wang X; Wang L; Lin R; Tao J; Chen L
    Int J Mol Med; 2016 Feb; 37(2):309-18. PubMed ID: 26647915
    [TBL] [Abstract][Full Text] [Related]  

  • 18. mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery.
    Dauner K; Eid W; Raghupathy R; Presley JF; Zha X
    J Biol Chem; 2017 Apr; 292(14):5737-5747. PubMed ID: 28196862
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.
    Efeyan A; Zoncu R; Chang S; Gumper I; Snitkin H; Wolfson RL; Kirak O; Sabatini DD; Sabatini DM
    Nature; 2013 Jan; 493(7434):679-83. PubMed ID: 23263183
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification.
    Zi Z; Zhang Z; Feng Q; Kim C; Wang XD; Scherer PE; Gao J; Levine B; Yu Y
    Nat Commun; 2022 Apr; 13(1):1760. PubMed ID: 35365663
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.