174 related articles for article (PubMed ID: 28878225)
1. The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway.
Khan AUH; Allende-Vega N; Gitenay D; Gerbal-Chaloin S; Gondeau C; Vo DN; Belkahla S; Orecchioni S; Talarico G; Bertolini F; Bozic M; Valdivielso JM; Bejjani F; Jariel I; Lopez-Mejia IC; Fajas L; Lecellier CH; Hernandez J; Daujat M; Villalba M
Sci Rep; 2017 Sep; 7(1):10654. PubMed ID: 28878225
[TBL] [Abstract][Full Text] [Related]
2. Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase.
Kinnaird A; Dromparis P; Saleme B; Gurtu V; Watson K; Paulin R; Zervopoulos S; Stenson T; Sutendra G; Pink DB; Carmine-Simmen K; Moore R; Lewis JD; Michelakis ED
Eur Urol; 2016 Apr; 69(4):734-744. PubMed ID: 26433571
[TBL] [Abstract][Full Text] [Related]
3. Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: a role of reorganized glucose metabolism, cell survival regulation and macrophage differentiation.
Kumar A; Kant S; Singh SM
Toxicol Appl Pharmacol; 2013 Nov; 273(1):196-208. PubMed ID: 24051182
[TBL] [Abstract][Full Text] [Related]
4. Activation of mitochondrial oxidation by PDK2 inhibition reverses cisplatin resistance in head and neck cancer.
Roh JL; Park JY; Kim EH; Jang HJ; Kwon M
Cancer Lett; 2016 Feb; 371(1):20-9. PubMed ID: 26607904
[TBL] [Abstract][Full Text] [Related]
5. Synergistic anticancer potential of dichloroacetate and estradiol analogue exerting their effect via ROS-JNK-Bcl-2-mediated signalling pathways.
Stander XX; Stander BA; Joubert AM
Cell Physiol Biochem; 2015; 35(4):1499-526. PubMed ID: 25791820
[TBL] [Abstract][Full Text] [Related]
6. Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism.
Makita N; Ishiguro J; Suzuki K; Nara F
J Pharm Pharmacol; 2017 Jan; 69(1):43-51. PubMed ID: 27757958
[TBL] [Abstract][Full Text] [Related]
7. ERK5 regulates basic fibroblast growth factor-induced type 1 plasminogen activator inhibitor expression and cell proliferation in lung fibroblasts.
Han JH; Hwang AR; Nam DH; Kim S; Choi HC; Lim JH; Woo CH
Life Sci; 2015 Aug; 135():1-8. PubMed ID: 26032256
[TBL] [Abstract][Full Text] [Related]
8. Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants.
Kluza J; Corazao-Rozas P; Touil Y; Jendoubi M; Maire C; Guerreschi P; Jonneaux A; Ballot C; Balayssac S; Valable S; Corroyer-Dulmont A; Bernaudin M; Malet-Martino M; de Lassalle EM; Maboudou P; Formstecher P; Polakowska R; Mortier L; Marchetti P
Cancer Res; 2012 Oct; 72(19):5035-47. PubMed ID: 22865452
[TBL] [Abstract][Full Text] [Related]
9. A novel role for extracellular signal-regulated kinase 5 and myocyte enhancer factor 2 in medulloblastoma cell death.
Sturla LM; Cowan CW; Guenther L; Castellino RC; Kim JY; Pomeroy SL
Cancer Res; 2005 Jul; 65(13):5683-9. PubMed ID: 15994942
[TBL] [Abstract][Full Text] [Related]
10. Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis.
Nayak MK; Dhanesha N; Doddapattar P; Rodriguez O; Sonkar VK; Dayal S; Chauhan AK
Blood Adv; 2018 Aug; 2(15):2029-2038. PubMed ID: 30108111
[TBL] [Abstract][Full Text] [Related]
11. Mitochondrial Complex I activity signals antioxidant response through ERK5.
Khan AUH; Allende-Vega N; Gitenay D; Garaude J; Vo DN; Belkhala S; Gerbal-Chaloin S; Gondeau C; Daujat-Chavanieu M; Delettre C; Orecchioni S; Talarico G; Bertolini F; Anel A; Cuezva JM; Enriquez JA; Cartron G; Lecellier CH; Hernandez J; Villalba M
Sci Rep; 2018 May; 8(1):7420. PubMed ID: 29743487
[TBL] [Abstract][Full Text] [Related]
12. Targeting of two aspects of metabolism in breast cancer treatment.
Gang BP; Dilda PJ; Hogg PJ; Blackburn AC
Cancer Biol Ther; 2014; 15(11):1533-41. PubMed ID: 25482950
[TBL] [Abstract][Full Text] [Related]
13. Pyruvate dehydrogenase kinase regulates hepatitis C virus replication.
Jung GS; Jeon JH; Choi YK; Jang SY; Park SY; Kim SW; Byun JK; Kim MK; Lee S; Shin EC; Lee IK; Kang YN; Park KG
Sci Rep; 2016 Jul; 6():30846. PubMed ID: 27471054
[TBL] [Abstract][Full Text] [Related]
14. Reversal of the Warburg effect with DCA in PDGF‑treated human PASMC is potentiated by pyruvate dehydrogenase kinase‑1 inhibition mediated through blocking Akt/GSK‑3β signalling.
Li B; Zhu Y; Sun Q; Yu C; Chen L; Tian Y; Yan J
Int J Mol Med; 2018 Sep; 42(3):1391-1400. PubMed ID: 29956736
[TBL] [Abstract][Full Text] [Related]
15. Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α.
Škorja Milić N; Dolinar K; Miš K; Matkovič U; Bizjak M; Pavlin M; Podbregar M; Pirkmajer S
Int J Mol Sci; 2021 Aug; 22(16):. PubMed ID: 34445316
[TBL] [Abstract][Full Text] [Related]
16. The effect of dichloroacetate in canine prostate adenocarcinomas and transitional cell carcinomas in vitro.
Harting T; Stubbendorff M; Willenbrock S; Wagner S; Schadzek P; Ngezahayo A; Murua Escobar HM; Nolte I
Int J Oncol; 2016 Dec; 49(6):2341-2350. PubMed ID: 27748833
[TBL] [Abstract][Full Text] [Related]
17. Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation.
Kumar A; Kant S; Singh SM
Chem Biol Interact; 2012 Jul; 199(1):29-37. PubMed ID: 22705712
[TBL] [Abstract][Full Text] [Related]
18. Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors.
Zhang W; Hu X; Zhou W; Tam KY
J Proteome Res; 2018 Sep; 17(9):3012-3021. PubMed ID: 30028142
[TBL] [Abstract][Full Text] [Related]
19. Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells.
Haugrud AB; Zhuang Y; Coppock JD; Miskimins WK
Breast Cancer Res Treat; 2014 Oct; 147(3):539-50. PubMed ID: 25212175
[TBL] [Abstract][Full Text] [Related]
20. Overexpression of pyruvate dehydrogenase kinase supports dichloroacetate as a candidate for cutaneous melanoma therapy.
Pópulo H; Caldas R; Lopes JM; Pardal J; Máximo V; Soares P
Expert Opin Ther Targets; 2015 Jun; 19(6):733-45. PubMed ID: 25976231
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
