BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

288 related articles for article (PubMed ID: 28919040)

  • 1. Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.
    Guo Z; Sevrioukova IF; Denisov IG; Zhang X; Chiu TL; Thomas DG; Hanse EA; Cuellar RAD; Grinkova YV; Langenfeld VW; Swedien DS; Stamschror JD; Alvarez J; Luna F; Galván A; Bae YK; Wulfkuhle JD; Gallagher RI; Petricoin EF; Norris B; Flory CM; Schumacher RJ; O'Sullivan MG; Cao Q; Chu H; Lipscomb JD; Atkins WM; Gupta K; Kelekar A; Blair IA; Capdevila JH; Falck JR; Sligar SG; Poulos TL; Georg GI; Ambrose E; Potter DA
    Cell Chem Biol; 2017 Oct; 24(10):1259-1275.e6. PubMed ID: 28919040
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Targeting cytochrome P450-dependent cancer cell mitochondria: cancer associated CYPs and where to find them.
    Guo Z; Johnson V; Barrera J; Porras M; Hinojosa D; Hernández I; McGarrah P; Potter DA
    Cancer Metastasis Rev; 2018 Sep; 37(2-3):409-423. PubMed ID: 30066055
    [TBL] [Abstract][Full Text] [Related]  

  • 3. CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET).
    Mitra R; Guo Z; Milani M; Mesaros C; Rodriguez M; Nguyen J; Luo X; Clarke D; Lamba J; Schuetz E; Donner DB; Puli N; Falck JR; Capdevila J; Gupta K; Blair IA; Potter DA
    J Biol Chem; 2011 May; 286(20):17543-59. PubMed ID: 21402692
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase.
    Bridges HR; Sirviö VA; Agip AN; Hirst J
    BMC Biol; 2016 Aug; 14():65. PubMed ID: 27506389
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Overexpression of CYP3A4, but not of CYP2D6, promotes hypoxic response and cell growth of Hep3B cells.
    Oguro A; Sakamoto K; Funae Y; Imaoka S
    Drug Metab Pharmacokinet; 2011; 26(4):407-15. PubMed ID: 21566342
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells.
    Orecchioni S; Reggiani F; Talarico G; Mancuso P; Calleri A; Gregato G; Labanca V; Noonan DM; Dallaglio K; Albini A; Bertolini F
    Int J Cancer; 2015 Mar; 136(6):E534-44. PubMed ID: 25196138
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Phenylethynylbenzyl-modified biguanides inhibit pancreatic cancer tumor growth.
    Hébert A; Parisotto M; Rowell MC; Doré A; Fernandez Ruiz A; Lefrançois G; Kalegari P; Ferbeyre G; Schmitzer AR
    Sci Rep; 2021 May; 11(1):9854. PubMed ID: 33972583
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles.
    Barr JT; Wang Z; Min X; Wienkers HJ; Rock BM; Rock DA; Wienkers LC
    Drug Metab Dispos; 2020 Jun; 48(6):508-514. PubMed ID: 32193357
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport.
    Velez J; Pan R; Lee JT; Enciso L; Suarez M; Duque JE; Jaramillo D; Lopez C; Morales L; Bornmann W; Konopleva M; Krystal G; Andreeff M; Samudio I
    Oncotarget; 2016 Aug; 7(32):51435-51449. PubMed ID: 27283492
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of CYP3A4 inhibitors as potential anti-cancer agents using pharmacoinformatics approach.
    Wanjari PJ; Rath A; Sathe RY; Bharatam PV
    J Mol Model; 2023 Apr; 29(5):156. PubMed ID: 37097473
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Improved cytochrome P450 3A4 molecular models accurately predict the Phe215 requirement for raloxifene dehydrogenation selectivity.
    Moore CD; Shahrokh K; Sontum SF; Cheatham TE; Yost GS
    Biochemistry; 2010 Oct; 49(41):9011-9. PubMed ID: 20812728
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Interaction of CYP3A4 with caffeine: First insights into multiple substrate binding.
    Sevrioukova IF
    J Biol Chem; 2023 Sep; 299(9):105117. PubMed ID: 37524132
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5.
    Wright WC; Chenge J; Wang J; Girvan HM; Yang L; Chai SC; Huber AD; Wu J; Oladimeji PO; Munro AW; Chen T
    J Med Chem; 2020 Feb; 63(3):1415-1433. PubMed ID: 31965799
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Sulfonamide metformin derivatives induce mitochondrial-associated apoptosis and cell cycle arrest in breast cancer cells.
    Markowicz-Piasecka M; Huttunen J; Zajda A; Sikora J; Huttunen KM
    Chem Biol Interact; 2022 Jan; 352():109795. PubMed ID: 34953865
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.
    Hinke SA; Martens GA; Cai Y; Finsi J; Heimberg H; Pipeleers D; Van de Casteele M
    Br J Pharmacol; 2007 Apr; 150(8):1031-43. PubMed ID: 17339833
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Role of human CYP3A4 in the biotransformation of sorafenib to its major oxidized metabolites.
    Ghassabian S; Rawling T; Zhou F; Doddareddy MR; Tattam BN; Hibbs DE; Edwards RJ; Cui PH; Murray M
    Biochem Pharmacol; 2012 Jul; 84(2):215-23. PubMed ID: 22513143
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The phenomenon of acquired resistance to metformin in breast cancer cells: The interaction of growth pathways and estrogen receptor signaling.
    Scherbakov AM; Sorokin DV; Tatarskiy VV; Prokhorov NS; Semina SE; Berstein LM; Krasil'nikov MA
    IUBMB Life; 2016 Apr; 68(4):281-92. PubMed ID: 26892736
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Quercetin inhibits the metabolism of arachidonic acid by inhibiting the activity of CYP3A4, thereby inhibiting the progression of breast cancer.
    Tang H; Kuang Y; Wu W; Peng B; Fu Q
    Mol Med; 2023 Sep; 29(1):127. PubMed ID: 37710176
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: the effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium.
    Davydov DR; Sineva EV; Sistla S; Davydova NY; Frank DJ; Sligar SG; Halpert JR
    Biochim Biophys Acta; 2010 Mar; 1797(3):378-90. PubMed ID: 20026040
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction.
    Bajpai P; Srinivasan S; Ghosh J; Nagy LD; Wei S; Guengerich FP; Avadhani NG
    J Biol Chem; 2014 Oct; 289(43):29614-30. PubMed ID: 25160618
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.