230 related articles for article (PubMed ID: 28935770)
1. Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
de Araujo MEG; Naschberger A; Fürnrohr BG; Stasyk T; Dunzendorfer-Matt T; Lechner S; Welti S; Kremser L; Shivalingaiah G; Offterdinger M; Lindner HH; Huber LA; Scheffzek K
Science; 2017 Oct; 358(6361):377-381. PubMed ID: 28935770
[TBL] [Abstract][Full Text] [Related]
2. Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1.
Nada S; Okada M
J Biochem; 2020 Dec; 168(6):621-632. PubMed ID: 32653916
[TBL] [Abstract][Full Text] [Related]
3. Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Yonehara R; Nada S; Nakai T; Nakai M; Kitamura A; Ogawa A; Nakatsumi H; Nakayama KI; Li S; Standley DM; Yamashita E; Nakagawa A; Okada M
Nat Commun; 2017 Nov; 8(1):1625. PubMed ID: 29158492
[TBL] [Abstract][Full Text] [Related]
4. Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.
Zhang T; Wang R; Wang Z; Wang X; Wang F; Ding J
Nat Commun; 2017 Nov; 8(1):1394. PubMed ID: 29123114
[TBL] [Abstract][Full Text] [Related]
5. The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex.
Deng Y; Qin Y; Srikantan S; Luo A; Cheng ZM; Flores SK; Vogel KS; Wang E; Dahia PLM
Hum Mol Genet; 2018 May; 27(10):1794-1808. PubMed ID: 29547888
[TBL] [Abstract][Full Text] [Related]
6. Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability.
Mutvei AP; Nagiec MJ; Hamann JC; Kim SG; Vincent CT; Blenis J
Nat Commun; 2020 Mar; 11(1):1416. PubMed ID: 32184389
[TBL] [Abstract][Full Text] [Related]
7. A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold.
Lawrence RE; Cho KF; Rappold R; Thrun A; Tofaute M; Kim DJ; Moldavski O; Hurley JH; Zoncu R
Nat Cell Biol; 2018 Sep; 20(9):1052-1063. PubMed ID: 30061680
[TBL] [Abstract][Full Text] [Related]
8. p18/LAMTOR1: a late endosome/lysosome-specific anchor protein for the mTORC1/MAPK signaling pathway.
Nada S; Mori S; Takahashi Y; Okada M
Methods Enzymol; 2014; 535():249-63. PubMed ID: 24377928
[TBL] [Abstract][Full Text] [Related]
9. Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
Su MY; Morris KL; Kim DJ; Fu Y; Lawrence R; Stjepanovic G; Zoncu R; Hurley JH
Mol Cell; 2017 Dec; 68(5):835-846.e3. PubMed ID: 29107538
[TBL] [Abstract][Full Text] [Related]
10. SAMTOR is an
Gu X; Orozco JM; Saxton RA; Condon KJ; Liu GY; Krawczyk PA; Scaria SM; Harper JW; Gygi SP; Sabatini DM
Science; 2017 Nov; 358(6364):813-818. PubMed ID: 29123071
[TBL] [Abstract][Full Text] [Related]
11. KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
Yan G; Li X; Zheng Z; Gao W; Chen C; Wang X; Cheng Z; Yu J; Zou G; Farooq MZ; Zhu X; Zhu W; Zhong Q; Yan X
Autophagy; 2022 Dec; 18(12):2799-2816. PubMed ID: 35266843
[TBL] [Abstract][Full Text] [Related]
12. [New structures of mTORC1: Focus on Rag GTPases].
Nawrotek A; Cherfils J
Med Sci (Paris); 2021 Apr; 37(4):372-378. PubMed ID: 33908855
[TBL] [Abstract][Full Text] [Related]
13. An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids.
Egri SB; Shen K
J Biol Chem; 2021 Jul; 297(1):100861. PubMed ID: 34116056
[TBL] [Abstract][Full Text] [Related]
14. Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.
Shen K; Sabatini DM
Proc Natl Acad Sci U S A; 2018 Sep; 115(38):9545-9550. PubMed ID: 30181260
[TBL] [Abstract][Full Text] [Related]
15. A Ragulator-BORC interaction controls lysosome positioning in response to amino acid availability.
Pu J; Keren-Kaplan T; Bonifacino JS
J Cell Biol; 2017 Dec; 216(12):4183-4197. PubMed ID: 28993468
[TBL] [Abstract][Full Text] [Related]
16. Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane.
Mu Z; Wang L; Deng W; Wang J; Wu G
Cell Discov; 2017; 3():17049. PubMed ID: 29285400
[TBL] [Abstract][Full Text] [Related]
17. The GATOR-Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids.
Hesketh GG; Papazotos F; Pawling J; Rajendran D; Knight JDR; Martinez S; Taipale M; Schramek D; Dennis JW; Gingras AC
Science; 2020 Oct; 370(6514):351-356. PubMed ID: 33060361
[TBL] [Abstract][Full Text] [Related]
18. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
Bar-Peled L; Schweitzer LD; Zoncu R; Sabatini DM
Cell; 2012 Sep; 150(6):1196-208. PubMed ID: 22980980
[TBL] [Abstract][Full Text] [Related]
19. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.
Zoncu R; Bar-Peled L; Efeyan A; Wang S; Sancak Y; Sabatini DM
Science; 2011 Nov; 334(6056):678-83. PubMed ID: 22053050
[TBL] [Abstract][Full Text] [Related]
20. Recent advances in understanding of amino acid signaling to mTORC1 activation.
Zhuang Y; Wang XX; He J; He S; Yin Y
Front Biosci (Landmark Ed); 2019 Mar; 24(5):971-982. PubMed ID: 30844724
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]