BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

201 related articles for article (PubMed ID: 28937750)

  • 1. Active Site Metal Identity Alters Histone Deacetylase 8 Substrate Selectivity: A Potential Novel Regulatory Mechanism.
    Castaneda CA; Lopez JE; Joseph CG; Scholle MD; Mrksich M; Fierke CA
    Biochemistry; 2017 Oct; 56(42):5663-5670. PubMed ID: 28937750
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Kinetics and thermodynamics of metal-binding to histone deacetylase 8.
    Kim B; Pithadia AS; Fierke CA
    Protein Sci; 2015 Mar; 24(3):354-65. PubMed ID: 25516458
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion.
    Gantt SL; Gattis SG; Fierke CA
    Biochemistry; 2006 May; 45(19):6170-8. PubMed ID: 16681389
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Histone Deacetylase 8: Characterization of Physiological Divalent Metal Catalysis.
    Nechay MR; Gallup NM; Morgenstern A; Smith QA; Eberhart ME; Alexandrova AN
    J Phys Chem B; 2016 Jul; 120(26):5884-95. PubMed ID: 26996235
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function .
    Dowling DP; Gattis SG; Fierke CA; Christianson DW
    Biochemistry; 2010 Jun; 49(24):5048-56. PubMed ID: 20545365
    [TBL] [Abstract][Full Text] [Related]  

  • 6. HDAC8 substrate selectivity is determined by long- and short-range interactions leading to enhanced reactivity for full-length histone substrates compared with peptides.
    CastaƱeda CA; Wolfson NA; Leng KR; Kuo YM; Andrews AJ; Fierke CA
    J Biol Chem; 2017 Dec; 292(52):21568-21577. PubMed ID: 29109148
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of the Phosphomimetic S39E Mutant.
    Welker Leng KR; CastaƱeda CA; Decroos C; Islam B; Haider SM; Christianson DW; Fierke CA
    Biochemistry; 2019 Nov; 58(45):4480-4493. PubMed ID: 31633931
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-Based Identification of HDAC8 Non-histone Substrates.
    Alam N; Zimmerman L; Wolfson NA; Joseph CG; Fierke CA; Schueler-Furman O
    Structure; 2016 Mar; 24(3):458-68. PubMed ID: 26933971
    [TBL] [Abstract][Full Text] [Related]  

  • 9. HDAC8 Catalyzes the Hydrolysis of Long Chain Fatty Acyl Lysine.
    Aramsangtienchai P; Spiegelman NA; He B; Miller SP; Dai L; Zhao Y; Lin H
    ACS Chem Biol; 2016 Oct; 11(10):2685-2692. PubMed ID: 27459069
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Restoring histone deacetylase activity by waste product release. A view from molecular mechanics simulations with mammalian HDAC8.
    Pietra F
    Chem Biodivers; 2015 Apr; 12(4):503-12. PubMed ID: 25879496
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor.
    Hu E; Chen Z; Fredrickson T; Zhu Y; Kirkpatrick R; Zhang GF; Johanson K; Sung CM; Liu R; Winkler J
    J Biol Chem; 2000 May; 275(20):15254-64. PubMed ID: 10748112
    [TBL] [Abstract][Full Text] [Related]  

  • 12. General Base-General Acid Catalysis in Human Histone Deacetylase 8.
    Gantt SM; Decroos C; Lee MS; Gullett LE; Bowman CM; Christianson DW; Fierke CA
    Biochemistry; 2016 Feb; 55(5):820-32. PubMed ID: 26806311
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
    Dowling DP; Gantt SL; Gattis SG; Fierke CA; Christianson DW
    Biochemistry; 2008 Dec; 47(51):13554-63. PubMed ID: 19053282
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Acetanilide and bromoacetyl-lysine derivatives as activators for human histone deacetylase 8.
    Mukhtar YM; Huang Y; Liu J; Chen D; Zheng W
    Bioorg Med Chem Lett; 2017 Jun; 27(11):2319-2323. PubMed ID: 28442255
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The activity of HDAC8 depends on local and distal sequences of its peptide substrates.
    Gurard-Levin ZA; Mrksich M
    Biochemistry; 2008 Jun; 47(23):6242-50. PubMed ID: 18470998
    [TBL] [Abstract][Full Text] [Related]  

  • 16. HDAC8 Substrates Identified by Genetically Encoded Active Site Photocrosslinking.
    Lopez JE; Haynes SE; Majmudar JD; Martin BR; Fierke CA
    J Am Chem Soc; 2017 Nov; 139(45):16222-16227. PubMed ID: 29035536
    [TBL] [Abstract][Full Text] [Related]  

  • 17. KDAC8 substrate specificity quantified by a biologically relevant, label-free deacetylation assay.
    Toro TB; Watt TJ
    Protein Sci; 2015 Dec; 24(12):2020-32. PubMed ID: 26402585
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
    Marek M; Shaik TB; Heimburg T; Chakrabarti A; Lancelot J; Ramos-Morales E; Da Veiga C; Kalinin D; Melesina J; Robaa D; Schmidtkunz K; Suzuki T; Holl R; Ennifar E; Pierce RJ; Jung M; Sippl W; Romier C
    J Med Chem; 2018 Nov; 61(22):10000-10016. PubMed ID: 30347148
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8.
    Porter NJ; Christianson DW
    ACS Chem Biol; 2017 Sep; 12(9):2281-2286. PubMed ID: 28846375
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme.
    Singh RK; Suzuki T; Mandal T; Balsubramanian N; Haldar M; Mueller DJ; Strode JA; Cook G; Mallik S; Srivastava DK
    Biochemistry; 2014 Dec; 53(48):7445-58. PubMed ID: 25407689
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.