BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

154 related articles for article (PubMed ID: 28941814)

  • 21. Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers.
    Smellie M; Bose DS; Thompson AS; Jenkins TC; Hartley JA; Thurston DE
    Biochemistry; 2003 Jul; 42(27):8232-9. PubMed ID: 12846572
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates.
    Vlahov IR; Qi L; Kleindl PJ; Santhapuram HK; Felten A; Parham GL; Wang K; You F; Vaughn JF; Hahn SJ; Klein HF; Vetzel M; Reddy JA; Nelson M; Nicoson J; Leamon CP
    Bioconjug Chem; 2017 Dec; 28(12):2921-2931. PubMed ID: 29211454
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Physical and structural basis for the strong interactions of the -ImPy- central pairing motif in the polyamide f-ImPyIm.
    Buchmueller KL; Bailey SL; Matthews DA; Taherbhai ZT; Register JK; Davis ZS; Bruce CD; O'Hare C; Hartley JA; Lee M
    Biochemistry; 2006 Nov; 45(45):13551-65. PubMed ID: 17087509
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity.
    Kopka ML; Goodsell DS; Baikalov I; Grzeskowiak K; Cascio D; Dickerson RE
    Biochemistry; 1994 Nov; 33(46):13593-610. PubMed ID: 7947769
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Computational studies support the role of the C7-sibirosamine sugar of the pyrrolobenzodiazepine (PBD) sibiromycin in transcription factor inhibition.
    Jackson PJ; James CH; Jenkins TC; Rahman KM; Thurston DE
    ACS Chem Biol; 2014 Oct; 9(10):2432-40. PubMed ID: 25111266
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Observation of a dynamic equilibrium between DNA hairpin and duplex forms of covalent adducts of a minor groove binding agent.
    Rahman KM; Mussa V; Narayanaswamy M; James CH; Howard PW; Thurston DE
    Chem Commun (Camb); 2009 Jan; (2):227-9. PubMed ID: 19099077
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides.
    Gottesfeld JM; Melander C; Suto RK; Raviol H; Luger K; Dervan PB
    J Mol Biol; 2001 Jun; 309(3):615-29. PubMed ID: 11397084
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers.
    Rahman KM; James CH; Thurston DE
    Nucleic Acids Res; 2011 Jul; 39(13):5800-12. PubMed ID: 21427082
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Inter- and intrastrand DNA crosslinks by 2-fluoro-substituted pyrrolobenzodiazepine dimers: stability, stereochemistry and drug orientation.
    Seifert J; Pezeshki S; Kamal A; Weisz K
    Org Biomol Chem; 2012 Sep; 10(34):6850-60. PubMed ID: 22837138
    [TBL] [Abstract][Full Text] [Related]  

  • 30. DNA sequence recognition by an isopropyl substituted thiazole polyamide.
    James PL; Merkina EE; Khalaf AI; Suckling CJ; Waigh RD; Brown T; Fox KR
    Nucleic Acids Res; 2004; 32(11):3410-7. PubMed ID: 15247333
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Footprinting methods for analysis of pyrrole-imidazole polyamide/DNA complexes.
    Trauger JW; Dervan PB
    Methods Enzymol; 2001; 340():450-66. PubMed ID: 11494863
    [No Abstract]   [Full Text] [Related]  

  • 32. DNA triple helix stabilisation by covalent attachment of a triplex-specific ligand.
    Keppler MD; McKeen CM; Zegrocka O; Strekowski L; Brown T; Fox KR
    Biochim Biophys Acta; 1999 Oct; 1447(2-3):137-45. PubMed ID: 10542311
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Stable DNA triple helix formation using oligonucleotides containing 2'-aminoethoxy,5-propargylamino-U.
    Sollogoub M; Darby RA; Cuenoud B; Brown T; Fox KR
    Biochemistry; 2002 Jun; 41(23):7224-31. PubMed ID: 12044153
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Solution structure of a 2:1 C2-(2-naphthyl) pyrrolo[2,1-c][1,4]benzodiazepine DNA adduct: molecular basis for unexpectedly high DNA helix stabilization.
    Antonow D; Barata T; Jenkins TC; Parkinson GN; Howard PW; Thurston DE; Zloh M
    Biochemistry; 2008 Nov; 47(45):11818-29. PubMed ID: 18925745
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Effect of microwave irradiation on covalent ligand-DNA interactions.
    Rahman KM; Thurston DE
    Chem Commun (Camb); 2009 May; (20):2875-7. PubMed ID: 19436895
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.
    Wells G; Martin CR; Howard PW; Sands ZA; Laughton CA; Tiberghien A; Woo CK; Masterson LA; Stephenson MJ; Hartley JA; Jenkins TC; Shnyder SD; Loadman PM; Waring MJ; Thurston DE
    J Med Chem; 2006 Sep; 49(18):5442-61. PubMed ID: 16942018
    [TBL] [Abstract][Full Text] [Related]  

  • 37. CD and melting curves structural studies of the tandem DNA complex formed with oligonucleotides carrying photoactive and sensitizing groups in the nick region.
    Koval VV; Pyshnyi D; Fedorova O
    J Biomol Struct Dyn; 2001 Dec; 19(3):515-26. PubMed ID: 11790149
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates.
    Rahman KM; Rosado H; Moreira JB; Feuerbaum EA; Fox KR; Stecher E; Howard PW; Gregson SJ; James CH; de la Fuente M; Waldron DE; Thurston DE; Taylor PW
    J Antimicrob Chemother; 2012 Jul; 67(7):1683-96. PubMed ID: 22547662
    [TBL] [Abstract][Full Text] [Related]  

  • 39. DNA sequence recognition by bispyrazinonaphthalimides antitumor agents.
    Carrasco C; Joubert A; Tardy C; Maestre N; Cacho M; BraƱa MF; Bailly C
    Biochemistry; 2003 Oct; 42(40):11751-61. PubMed ID: 14529286
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Spectroscopic and calorimetric studies on the DNA recognition of pyrrolo[2,1-c][1,4]benzodiazepine hybrids.
    Rettig M; Kamal A; Ramu R; Mikolajczak J; Weisz K
    Bioorg Med Chem; 2009 Jan; 17(2):919-28. PubMed ID: 19056283
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.