BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

167 related articles for article (PubMed ID: 28945287)

  • 1. Comparing BMD-derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay.
    Wills JW; Johnson GE; Battaion HL; Slob W; White PA
    Environ Mol Mutagen; 2017 Dec; 58(9):632-643. PubMed ID: 28945287
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adult gpt-delta transgenic mice.
    Cao X; Mittelstaedt RA; Pearce MG; Allen BC; Soeteman-Hernández LG; Johnson GE; Bigger CA; Heflich RH
    Environ Mol Mutagen; 2014 Jun; 55(5):385-99. PubMed ID: 24535894
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment.
    Johnson GE; Soeteman-Hernández LG; Gollapudi BB; Bodger OG; Dearfield KL; Heflich RH; Hixon JG; Lovell DP; MacGregor JT; Pottenger LH; Thompson CM; Abraham L; Thybaud V; Tanir JY; Zeiger E; van Benthem J; White PA
    Environ Mol Mutagen; 2014 Oct; 55(8):609-23. PubMed ID: 24801602
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment.
    Wills JW; Long AS; Johnson GE; Bemis JC; Dertinger SD; Slob W; White PA
    Mutagenesis; 2016 May; 31(3):265-75. PubMed ID: 26984301
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Determination of potential thresholds for N-ethyl-N-nitrosourea and ethyl methanesulfonate based on a multi-endpoint genotoxicity assessment platform in rats.
    Zhu X; Huo J; Zeng Z; Liu Y; Li R; Chen Y; Zhang L; Chen J
    Environ Sci Pollut Res Int; 2022 Dec; 29(56):85128-85142. PubMed ID: 35793016
    [TBL] [Abstract][Full Text] [Related]  

  • 6. N-Nitrosodimethylamine investigations in Muta™Mouse define point-of-departure values and demonstrate less-than-additive somatic mutant frequency accumulations.
    Lynch AM; Howe J; Hildebrand D; Harvey JS; Burman M; Harte DSG; Chen L; Kmett C; Shi W; McHugh CF; Patel KK; Junnotula V; Kenny J; Haworth R; Wills JW
    Mutagenesis; 2024 Mar; 39(2):96-118. PubMed ID: 38183622
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Sublinear response in lacZ mutant frequency of Muta™ Mouse spermatogonial stem cells after low dose subchronic exposure to N-ethyl-N-nitrosourea.
    O'Brien JM; Walker M; Sivathayalan A; Douglas GR; Yauk CL; Marchetti F
    Environ Mol Mutagen; 2015 May; 56(4):347-55. PubMed ID: 25598316
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Evaluation of in vivo genotoxicity induced by N-ethyl-N-nitrosourea, benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the Pig-a and gpt assays.
    Horibata K; Ukai A; Kimoto T; Suzuki T; Kamoshita N; Masumura K; Nohmi T; Honma M
    Environ Mol Mutagen; 2013 Dec; 54(9):747-54. PubMed ID: 24105957
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Empirical analysis of BMD metrics in genetic toxicology part I: in vitro analyses to provide robust potency rankings and support MOA determinations.
    Wills JW; Johnson GE; Doak SH; Soeteman-Hernández LG; Slob W; White PA
    Mutagenesis; 2016 May; 31(3):255-63. PubMed ID: 26687511
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the Muta™Mouse transgenic rodent assay.
    Long AS; Lemieux CL; Arlt VM; White PA
    Toxicol Appl Pharmacol; 2016 Jan; 290():31-42. PubMed ID: 26603514
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose-response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose-response data.
    Chepelev N; Long AS; Beal M; Barton-Maclaren T; Johnson G; Dearfield KL; Roberts DJ; van Benthem J; White P
    Environ Mol Mutagen; 2023 Jan; 64(1):4-15. PubMed ID: 36345771
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Comparison of the transgenic rodent mutation assay, error corrected next generation duplex sequencing, and the alkaline comet assay to detect dose-related mutations following exposure to N-nitrosodiethylamine.
    Bercu JP; Zhang S; Sobol Z; Escobar PA; Van P; Schuler M
    Mutat Res Genet Toxicol Environ Mutagen; 2023 Oct; 891():503685. PubMed ID: 37770142
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The use of benchmark dose uncertainty measurements for robust comparative potency analyses.
    Wheeldon RP; Dertinger SD; Bryce SM; Bemis JC; Johnson GE
    Environ Mol Mutagen; 2021 Mar; 62(3):203-215. PubMed ID: 33428310
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Benchmark dose analyses of multiple genetic toxicity endpoints permit robust, cross-tissue comparisons of MutaMouse responses to orally delivered benzo[a]pyrene.
    Long AS; Wills JW; Krolak D; Guo M; Dertinger SD; Arlt VM; White PA
    Arch Toxicol; 2018 Feb; 92(2):967-982. PubMed ID: 29177888
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Quantitative Interpretation of Genetic Toxicity Dose-Response Data for Risk Assessment and Regulatory Decision-Making: Current Status and Emerging Priorities.
    White PA; Long AS; Johnson GE
    Environ Mol Mutagen; 2020 Jan; 61(1):66-83. PubMed ID: 31794061
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The application of the restriction site mutation assay to compare 1-ethyl-1-nitrosourea-induced mutations between the endogenous p53 gene and the transgenic LacZ gene in MutaMouse testes.
    Song HL; Jenkins GJ; Ashby J; Tinwell H; Parry JM
    Mutagenesis; 2001 Jan; 16(1):59-64. PubMed ID: 11139599
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Further characterization and validation of gpt delta transgenic mice for quantifying somatic mutations in vivo.
    Swiger RR; Cosentino L; Masumura KI; Nohmi T; Heddle JA
    Environ Mol Mutagen; 2001; 37(4):297-303. PubMed ID: 11424179
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Ethyl methanesulfonate toxicity in Viracept--a comprehensive human risk assessment based on threshold data for genotoxicity.
    Müller L; Gocke E; Lavé T; Pfister T
    Toxicol Lett; 2009 Nov; 190(3):317-29. PubMed ID: 19443141
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Comparison of dose-response relationships for ethyl methanesulfonate and 1-ethyl-1-nitrosourea in Drosophila melanogaster spermatozoa.
    Lee WR; Beranek DT; Byrne BJ; Tucker AB
    Mutat Res; 1990 Jul; 231(1):31-45. PubMed ID: 2114533
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations.
    Dearfield KL; Gollapudi BB; Bemis JC; Benz RD; Douglas GR; Elespuru RK; Johnson GE; Kirkland DJ; LeBaron MJ; Li AP; Marchetti F; Pottenger LH; Rorije E; Tanir JY; Thybaud V; van Benthem J; Yauk CL; Zeiger E; Luijten M
    Environ Mol Mutagen; 2017 Jun; 58(5):264-283. PubMed ID: 27650663
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.