BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

106 related articles for article (PubMed ID: 28953373)

  • 1. Identification of the Privileged Position in the Imidazo[1,2-a]pyridine Ring of Phosphonocarboxylates for Development of Rab Geranylgeranyl Transferase (RGGT) Inhibitors.
    Kaźmierczak A; Kusy D; Niinivehmas SP; Gmach J; Joachimiak Ł; Pentikäinen OT; Gendaszewska-Darmach E; Błażewska KM
    J Med Chem; 2017 Nov; 60(21):8781-8800. PubMed ID: 28953373
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and Biological Evaluation of Imidazole-Bearing α-Phosphonocarboxylates as Inhibitors of Rab Geranylgeranyl Transferase (RGGT).
    Joachimiak Ł; Marchwicka A; Gendaszewska-Darmach E; Błażewska KM
    ChemMedChem; 2018 Apr; 13(8):842-851. PubMed ID: 29498238
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rational design, optimization, and biological evaluation of novel α-Phosphonopropionic acids as covalent inhibitors of Rab geranylgeranyl transferase.
    Małolepsza J; Marchwicka A; Serwa RA; Niinivehmas SP; Pentikäinen OT; Gendaszewska-Darmach E; Błażewska KM
    J Enzyme Inhib Med Chem; 2022 Dec; 37(1):940-951. PubMed ID: 35354390
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT.
    Coxon FP; Joachimiak L; Najumudeen AK; Breen G; Gmach J; Oetken-Lindholm C; Way R; Dunford JE; Abankwa D; Błażewska KM
    Eur J Med Chem; 2014 Sep; 84():77-89. PubMed ID: 25016230
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase.
    Baron RA; Tavaré R; Figueiredo AC; Błazewska KM; Kashemirov BA; McKenna CE; Ebetino FH; Taylor A; Rogers MJ; Coxon FP; Seabra MC
    J Biol Chem; 2009 Mar; 284(11):6861-8. PubMed ID: 19074143
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo.
    Coxon FP; Ebetino FH; Mules EH; Seabra MC; McKenna CE; Rogers MJ
    Bone; 2005 Sep; 37(3):349-58. PubMed ID: 16006204
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.
    McKenna CE; Kashemirov BA; Błazewska KM; Mallard-Favier I; Stewart CA; Rojas J; Lundy MW; Ebetino FH; Baron RA; Dunford JE; Kirsten ML; Seabra MC; Bala JL; Marma MS; Rogers MJ; Coxon FP
    J Med Chem; 2010 May; 53(9):3454-64. PubMed ID: 20394422
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates.
    Coxon FP; Taylor A; Stewart CA; Baron R; Seabra MC; Ebetino FH; Rogers MJ
    Bone; 2011 Jul; 49(1):111-21. PubMed ID: 21419243
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis of the 6-Substituted Imidazo[1,2-a]Pyridine-3-yl-2- Phosphonopropionic Acids as Potential Inhibitors of Rab Geranylgeranyl Transferase.
    Kusy D; Marchwicka A; Małolepsza J; Justyna K; Gendaszewska-Darmach E; Błażewska KM
    Front Chem; 2020; 8():596162. PubMed ID: 33490034
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.
    Leung KF; Baron R; Seabra MC
    J Lipid Res; 2006 Mar; 47(3):467-75. PubMed ID: 16401880
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein.
    Gutkowska M; Swiezewska E
    Mol Membr Biol; 2012 Nov; 29(7):243-56. PubMed ID: 22694141
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors.
    Błażewska KM; Ni F; Haiges R; Kashemirov BA; Coxon FP; Stewart CA; Baron R; Rogers MJ; Seabra MC; Ebetino FH; McKenna CE
    Eur J Med Chem; 2011 Oct; 46(10):4820-6. PubMed ID: 21889236
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease.
    Pereira-Leal JB; Hume AN; Seabra MC
    FEBS Lett; 2001 Jun; 498(2-3):197-200. PubMed ID: 11412856
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate.
    Baron RA; Seabra MC
    Biochem J; 2008 Oct; 415(1):67-75. PubMed ID: 18532927
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.
    Coxon FP; Helfrich MH; Larijani B; Muzylak M; Dunford JE; Marshall D; McKinnon AD; Nesbitt SA; Horton MA; Seabra MC; Ebetino FH; Rogers MJ
    J Biol Chem; 2001 Dec; 276(51):48213-22. PubMed ID: 11581260
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Applying the prodrug strategy to α-phosphonocarboxylate inhibitors of Rab GGTase--synthesis and stability studies.
    Joachimiak Ł; Janczewski Ł; Ciekot J; Boratyński J; Błażewska K
    Org Biomol Chem; 2015 Jun; 13(24):6844-56. PubMed ID: 26018626
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase.
    Deraeve C; Guo Z; Bon RS; Blankenfeldt W; DiLucrezia R; Wolf A; Menninger S; Stigter EA; Wetzel S; Choidas A; Alexandrov K; Waldmann H; Goody RS; Wu YW
    J Am Chem Soc; 2012 May; 134(17):7384-91. PubMed ID: 22480322
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase.
    Alexandrov K; Simon I; Yurchenko V; Iakovenko A; Rostkova E; Scheidig AJ; Goody RS
    Eur J Biochem; 1999 Oct; 265(1):160-70. PubMed ID: 10491170
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate.
    Marma MS; Xia Z; Stewart C; Coxon F; Dunford JE; Baron R; Kashemirov BA; Ebetino FH; Triffitt JT; Russell RG; McKenna CE
    J Med Chem; 2007 Nov; 50(24):5967-75. PubMed ID: 17975902
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells.
    Roelofs AJ; Hulley PA; Meijer A; Ebetino FH; Russell RG; Shipman CM
    Int J Cancer; 2006 Sep; 119(6):1254-61. PubMed ID: 16619218
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.