136 related articles for article (PubMed ID: 28957634)
1. The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging.
Zhang L; Chen L; Beck EM; Chappie TA; Coelho RV; Doran SD; Fan KH; Helal CJ; Humphrey JM; Hughes Z; Kuszpit K; Lachapelle EA; Lazzaro JT; Lee C; Mather RJ; Patel NC; Skaddan MB; Sciabola S; Verhoest PR; Young JM; Zasadny K; Villalobos A
J Med Chem; 2017 Oct; 60(20):8538-8551. PubMed ID: 28957634
[TBL] [Abstract][Full Text] [Related]
2. First-in-Human Evaluation of
Wakabayashi Y; Stenkrona P; Arakawa R; Yan X; Van Buskirk MG; Jenkins MD; Santamaria JAM; Maresca KP; Takano A; Liow JS; Chappie TA; Varrone A; Nag S; Zhang L; Hughes ZA; Schmidt CJ; Doran SD; Mannes A; Zanotti-Fregonara P; Ooms M; Morse CL; Zoghbi SS; Halldin C; Pike VW; Innis RB
J Nucl Med; 2022 Dec; 63(12):1919-1924. PubMed ID: 35772961
[TBL] [Abstract][Full Text] [Related]
3. An Empirical Quantitative Structure-Activity Relationship Equation Assists the Discovery of High-Affinity Phosphodiesterase 4D Inhibitors as Leads to PET Radioligands.
Jiang M; Lu S; Telu S; Pike VW
J Med Chem; 2023 Jan; 66(2):1543-1561. PubMed ID: 36608175
[TBL] [Abstract][Full Text] [Related]
4. Efficiency gains in tracer identification for nuclear imaging: can in vivo LC-MS/MS evaluation of small molecules screen for successful PET tracers?
Joshi EM; Need A; Schaus J; Chen Z; Benesh D; Mitch C; Morton S; Raub TJ; Phebus L; Barth V
ACS Chem Neurosci; 2014 Dec; 5(12):1154-63. PubMed ID: 25247893
[TBL] [Abstract][Full Text] [Related]
5. Rapid identification of a novel phosphodiesterase 7B tracer for receptor occupancy studies using LC─MS/MS.
Chen J; Gu G; Chen M; Scott T; Heger L; Zook D; Chung D; Keenan T; Renick J; Santora VJ; Vivian J; Stauber K; Breitenbucher JG; Tabatabaei A
Neurochem Int; 2020 Jul; 137():104735. PubMed ID: 32246980
[TBL] [Abstract][Full Text] [Related]
6. Discovery, Radiolabeling, and Evaluation of Subtype-Selective Inhibitors for Positron Emission Tomography Imaging of Brain Phosphodiesterase-4D.
Wakabayashi Y; Telu S; Dick RM; Fujita M; Ooms M; Morse CL; Liow JS; Hong JS; Gladding RL; Manly LS; Zoghbi SS; Mo X; D'Amato EC; Sindac JA; Nugent RA; Marron BE; Gurney ME; Innis RB; Pike VW
ACS Chem Neurosci; 2020 May; 11(9):1311-1323. PubMed ID: 32212718
[TBL] [Abstract][Full Text] [Related]
7. Preclinical Evaluation of 18F-PF-05270430, a Novel PET Radioligand for the Phosphodiesterase 2A Enzyme.
Chen L; Nabulsi N; Naganawa M; Zasadny K; Skaddan MB; Zhang L; Najafzadeh S; Lin SF; Helal CJ; Boyden TL; Chang C; Ropchan J; Carson RE; Villalobos A; Huang Y
J Nucl Med; 2016 Sep; 57(9):1448-53. PubMed ID: 27199356
[TBL] [Abstract][Full Text] [Related]
8. AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer.
Chen H; Lester-Zeiner D; Shi J; Miller S; Glaus C; Hu E; Chen N; Able J; Biorn C; Wong J; Ma J; Michelsen K; Hill Della Puppa G; Kazules T; Dou HH; Talreja S; Zhao X; Chen A; Rumfelt S; Kunz RK; Ye H; Thiel OR; Williamson T; Davis C; Porter A; Immke D; Allen JR; Treanor J
J Pharmacol Exp Ther; 2015 Feb; 352(2):327-37. PubMed ID: 25502803
[TBL] [Abstract][Full Text] [Related]
9. Discovery of a highly specific
Xiao Z; Wei H; Xu Y; Haider A; Wei J; Yuan S; Rong J; Zhao C; Li G; Zhang W; Chen H; Li Y; Zhang L; Sun J; Zhang S; Luo HB; Yan S; Cai Q; Hou L; Che C; Liang SH; Wang L
Acta Pharm Sin B; 2022 Apr; 12(4):1963-1975. PubMed ID: 35847497
[TBL] [Abstract][Full Text] [Related]
10. Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors.
Cox CD; Hostetler ED; Flores BA; Evelhoch JL; Fan H; Gantert L; Holahan M; Eng W; Joshi A; McGaughey G; Meng X; Purcell M; Raheem IT; Riffel K; Yan Y; Renger JJ; Smith SM; Coleman PJ
Bioorg Med Chem Lett; 2015 Nov; 25(21):4893-4898. PubMed ID: 26077491
[TBL] [Abstract][Full Text] [Related]
11. Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand.
Zhang L; Villalobos A; Beck EM; Bocan T; Chappie TA; Chen L; Grimwood S; Heck SD; Helal CJ; Hou X; Humphrey JM; Lu J; Skaddan MB; McCarthy TJ; Verhoest PR; Wager TT; Zasadny K
J Med Chem; 2013 Jun; 56(11):4568-79. PubMed ID: 23651455
[TBL] [Abstract][Full Text] [Related]
12. Strategies to facilitate the discovery of novel CNS PET ligands.
Zhang L; Villalobos A
EJNMMI Radiopharm Chem; 2017; 1(1):13. PubMed ID: 29564389
[TBL] [Abstract][Full Text] [Related]
13. Preclinical evaluation of a promising C-11 labeled PET tracer for imaging phosphodiesterase 10A in the brain of living subject.
Liu H; Jin H; Yue X; Zhang X; Yang H; Li J; Flores H; Su Y; Perlmutter JS; Tu Z
Neuroimage; 2015 Nov; 121():253-62. PubMed ID: 26216275
[TBL] [Abstract][Full Text] [Related]
14. Robust Quantification of Phosphodiesterase-4D in Monkey Brain with PET and
Jiang M; Tang S; Jenkins MD; Lee AC; Kenou B; Knoer C; Montero Santamaria J; Wu S; Liow JS; Zoghbi SS; Zanotti-Fregonara P; Innis RB; Telu S; Pike VW
J Nucl Med; 2024 May; 65(5):788-793. PubMed ID: 38423785
[TBL] [Abstract][Full Text] [Related]
15. Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A.
Harada A; Suzuki K; Miura S; Hasui T; Kamiguchi N; Ishii T; Taniguchi T; Kuroita T; Takano A; Stepanov V; Halldin C; Kimura H
Nucl Med Biol; 2015 Feb; 42(2):146-54. PubMed ID: 25451212
[TBL] [Abstract][Full Text] [Related]
16. Discovery of selective PDE4B inhibitors.
Naganuma K; Omura A; Maekawara N; Saitoh M; Ohkawa N; Kubota T; Nagumo H; Kodama T; Takemura M; Ohtsuka Y; Nakamura J; Tsujita R; Kawasaki K; Yokoi H; Kawanishi M
Bioorg Med Chem Lett; 2009 Jun; 19(12):3174-6. PubMed ID: 19447034
[TBL] [Abstract][Full Text] [Related]
17. Preclinical evaluation of 18F-JNJ41510417 as a radioligand for PET imaging of phosphodiesterase-10A in the brain.
Celen S; Koole M; De Angelis M; Sannen I; Chitneni SK; Alcazar J; Dedeurwaerdere S; Moechars D; Schmidt M; Verbruggen A; Langlois X; Van Laere K; Andrés JI; Bormans G
J Nucl Med; 2010 Oct; 51(10):1584-91. PubMed ID: 20847170
[TBL] [Abstract][Full Text] [Related]
18. Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels.
Gómez-Vallejo V; Ugarte A; García-Barroso C; Cuadrado-Tejedor M; Szczupak B; Dopeso-Reyes IG; Lanciego JL; García-Osta A; Llop J; Oyarzabal J; Franco R
J Neurochem; 2016 Jan; 136(2):403-15. PubMed ID: 26641206
[TBL] [Abstract][Full Text] [Related]
19. Synthesis, 18F-Radiolabelling and Biological Characterization of Novel Fluoroalkylated Triazine Derivatives for in Vivo Imaging of Phosphodiesterase 2A in Brain via Positron Emission Tomography.
Schröder S; Wenzel B; Deuther-Conrad W; Teodoro R; Egerland U; Kranz M; Scheunemann M; Höfgen N; Steinbach J; Brust P
Molecules; 2015 May; 20(6):9591-615. PubMed ID: 26016549
[TBL] [Abstract][Full Text] [Related]
20. Label-free assay for the assessment of nonspecific binding of positron emission tomography tracer candidates.
Assmus F; Seelig A; Gobbi L; Borroni E; Glaentzlin P; Fischer H
Eur J Pharm Sci; 2015 Nov; 79():27-35. PubMed ID: 26341407
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
