BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1393 related articles for article (PubMed ID: 28959956)

  • 1. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
    Shi Y; Yamada K; Liddelow SA; Smith ST; Zhao L; Luo W; Tsai RM; Spina S; Grinberg LT; Rojas JC; Gallardo G; Wang K; Roh J; Robinson G; Finn MB; Jiang H; Sullivan PM; Baufeld C; Wood MW; Sutphen C; McCue L; Xiong C; Del-Aguila JL; Morris JC; Cruchaga C; ; Fagan AM; Miller BL; Boxer AL; Seeley WW; Butovsky O; Barres BA; Paul SM; Holtzman DM
    Nature; 2017 Sep; 549(7673):523-527. PubMed ID: 28959956
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.
    Williams T; Bathe T; Vo Q; Sacilotto P; McFarland K; Ruiz AJ; Hery GP; Sullivan P; Borchelt DR; Prokop S; Chakrabarty P
    Acta Neuropathol Commun; 2023 Jun; 11(1):99. PubMed ID: 37337279
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
    Wang C; Xiong M; Gratuze M; Bao X; Shi Y; Andhey PS; Manis M; Schroeder C; Yin Z; Madore C; Butovsky O; Artyomov M; Ulrich JD; Holtzman DM
    Neuron; 2021 May; 109(10):1657-1674.e7. PubMed ID: 33831349
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model.
    Litvinchuk A; Huynh TV; Shi Y; Jackson RJ; Finn MB; Manis M; Francis CM; Tran AC; Sullivan PM; Ulrich JD; Hyman BT; Cole T; Holtzman DM
    Ann Neurol; 2021 May; 89(5):952-966. PubMed ID: 33550655
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist.
    Litvinchuk A; Suh JH; Guo JL; Lin K; Davis SS; Bien-Ly N; Tycksen E; Tabor GT; Remolina Serrano J; Manis M; Bao X; Lee C; Bosch M; Perez EJ; Yuede CM; Cashikar AG; Ulrich JD; Di Paolo G; Holtzman DM
    Neuron; 2024 Feb; 112(3):384-403.e8. PubMed ID: 37995685
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Impact of APOE genotype on prion-type propagation of tauopathy.
    Williams T; Ruiz AJ; Ruiz AM; Vo Q; Tsering W; Xu G; McFarland K; Giasson BI; Sullivan P; Borchelt DR; Chakrabarty P
    Acta Neuropathol Commun; 2022 Apr; 10(1):57. PubMed ID: 35440098
    [TBL] [Abstract][Full Text] [Related]  

  • 7. APOE ε2 is associated with increased tau pathology in primary tauopathy.
    Zhao N; Liu CC; Van Ingelgom AJ; Linares C; Kurti A; Knight JA; Heckman MG; Diehl NN; Shinohara M; Martens YA; Attrebi ON; Petrucelli L; Fryer JD; Wszolek ZK; Graff-Radford NR; Caselli RJ; Sanchez-Contreras MY; Rademakers R; Murray ME; Koga S; Dickson DW; Ross OA; Bu G
    Nat Commun; 2018 Oct; 9(1):4388. PubMed ID: 30348994
    [TBL] [Abstract][Full Text] [Related]  

  • 8. APOE effects on regional tau in preclinical Alzheimer's disease.
    Young CB; Johns E; Kennedy G; Belloy ME; Insel PS; Greicius MD; Sperling RA; Johnson KA; Poston KL; Mormino EC; ;
    Mol Neurodegener; 2023 Jan; 18(1):1. PubMed ID: 36597122
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy.
    Koller EJ; Gonzalez De La Cruz E; Weinrich M; Williams T; Cruz PE; Ryu D; Golde TE; Sullivan PM; Lewis J; Borchelt DR; Chakrabarty P
    Mol Neurobiol; 2020 Apr; 57(4):1986-2001. PubMed ID: 31903524
    [TBL] [Abstract][Full Text] [Related]  

  • 10. TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4.
    Gratuze M; Schlachetzki JCM; D'Oliveira Albanus R; Jain N; Novotny B; Brase L; Rodriguez L; Mansel C; Kipnis M; O'Brien S; Pasillas MP; Lee C; Manis M; Colonna M; Harari O; Glass CK; Ulrich JD; Holtzman DM
    Neuron; 2023 Jan; 111(2):202-219.e7. PubMed ID: 36368315
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
    Brecht WJ; Harris FM; Chang S; Tesseur I; Yu GQ; Xu Q; Dee Fish J; Wyss-Coray T; Buttini M; Mucke L; Mahley RW; Huang Y
    J Neurosci; 2004 Mar; 24(10):2527-34. PubMed ID: 15014128
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation.
    Saroja SR; Gorbachev K; Julia T; Goate AM; Pereira AC
    Proc Natl Acad Sci U S A; 2022 Aug; 119(34):e2108870119. PubMed ID: 35969759
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Organotypic brain slice cultures of adult transgenic P301S mice--a model for tauopathy studies.
    Mewes A; Franke H; Singer D
    PLoS One; 2012; 7(9):e45017. PubMed ID: 22984603
    [TBL] [Abstract][Full Text] [Related]  

  • 14.
    Davis AA; Inman CE; Wargel ZM; Dube U; Freeberg BM; Galluppi A; Haines JN; Dhavale DD; Miller R; Choudhury FA; Sullivan PM; Cruchaga C; Perlmutter JS; Ulrich JD; Benitez BA; Kotzbauer PT; Holtzman DM
    Sci Transl Med; 2020 Feb; 12(529):. PubMed ID: 32024799
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice.
    Fitz NF; Wolfe CM; Playso BE; Biedrzycki RJ; Lu Y; Nam KN; Lefterov I; Koldamova R
    Mol Neurodegener; 2020 Jul; 15(1):41. PubMed ID: 32703241
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice.
    Chalermpalanupap T; Schroeder JP; Rorabaugh JM; Liles LC; Lah JJ; Levey AI; Weinshenker D
    J Neurosci; 2018 Jan; 38(1):74-92. PubMed ID: 29133432
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice.
    Pankiewicz JE; Guridi M; Kim J; Asuni AA; Sanchez S; Sullivan PM; Holtzman DM; Sadowski MJ
    Acta Neuropathol Commun; 2014 Jun; 2():75. PubMed ID: 24972680
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model.
    van Olst L; Verhaege D; Franssen M; Kamermans A; Roucourt B; Carmans S; Ytebrouck E; van der Pol SMA; Wever D; Popovic M; Vandenbroucke RE; Sobrino T; Schouten M; de Vries HE
    Neurobiol Aging; 2020 May; 89():89-98. PubMed ID: 32008854
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions.
    Sidoryk-Wegrzynowicz M; Gerber YN; Ries M; Sastre M; Tolkovsky AM; Spillantini MG
    Acta Neuropathol Commun; 2017 Nov; 5(1):89. PubMed ID: 29187256
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.
    Nelson MR; Liu P; Agrawal A; Yip O; Blumenfeld J; Traglia M; Kim MJ; Koutsodendris N; Rao A; Grone B; Hao Y; Yoon SY; Xu Q; De Leon S; Choenyi T; Thomas R; Lopera F; Quiroz YT; Arboleda-Velasquez JF; Reiman EM; Mahley RW; Huang Y
    Nat Neurosci; 2023 Dec; 26(12):2104-2121. PubMed ID: 37957317
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 70.