These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

69 related articles for article (PubMed ID: 28967705)

  • 1. Deciphering Structure-Activity Relationships in a Series of 2,2-Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants.
    Pirotte B; Florence X; Goffin E; Lebrun P
    ChemMedChem; 2017 Nov; 12(21):1810-1817. PubMed ID: 28967705
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 4,6-Disubstituted 2,2-dimethylchromans structurally related to the K(ATP) channel opener cromakalim: design, synthesis, and effect on insulin release and vascular tone.
    Sebille S; de Tullio P; Becker B; Antoine MH; Boverie S; Pirotte B; Lebrun P
    J Med Chem; 2005 Jan; 48(2):614-21. PubMed ID: 15658874
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: from potassium channel openers to calcium entry blockers?
    Florence X; Desvaux V; Goffin E; de Tullio P; Pirotte B; Lebrun P
    Eur J Med Chem; 2014 Jun; 80():36-46. PubMed ID: 24763361
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Research Advancements on Fluorinated and Non-Fluorinated 4- Phenyl(thio)ureido-Substituted 2,2-Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants.
    Pirotte B; Florence X; Goffin E; Leleux F; Lebrun P
    Med Chem; 2022; 18(8):884-894. PubMed ID: 35189799
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion.
    Pirotte B; Florence X; Goffin E; Medeiros MB; de Tullio P; Lebrun P
    Eur J Med Chem; 2016 Oct; 121():338-351. PubMed ID: 27267004
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels.
    Pirotte B; de Tullio P; Boverie S; Michaux C; Lebrun P
    J Med Chem; 2011 May; 54(9):3188-99. PubMed ID: 21428460
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.
    Khelili S; Florence X; Bouhadja M; Abdelaziz S; Mechouch N; Mohamed Y; de Tullio P; Lebrun P; Pirotte B
    Bioorg Med Chem; 2008 Jun; 16(11):6124-30. PubMed ID: 18479927
    [TBL] [Abstract][Full Text] [Related]  

  • 8. New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers.
    Sebille S; de Tullio P; Florence X; Becker B; Antoine MH; Michaux C; Wouters J; Pirotte B; Lebrun P
    Bioorg Med Chem; 2008 May; 16(10):5704-19. PubMed ID: 18406154
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 2,2-Dimethyl-3,4-dihydro-2
    Pirotte B; Florence X; Goffin E; Lebrun P
    Medchemcomm; 2019 Mar; 10(3):431-438. PubMed ID: 31015906
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: effect of 6,7-disubstitution on potency and tissue selectivity.
    de Tullio P; Boverie S; Becker B; Antoine MH; Nguyen QA; Francotte P; Counerotte S; Sebille S; Pirotte B; Lebrun P
    J Med Chem; 2005 Jul; 48(15):4990-5000. PubMed ID: 16033278
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effect on K(ATP) channel activation properties and tissue selectivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides.
    Boverie S; Antoine MH; Somers F; Becker B; Sebille S; Ouedraogo R; Counerotte S; Pirotte B; Lebrun P; de Tullio P
    J Med Chem; 2005 May; 48(10):3492-503. PubMed ID: 15887958
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides.
    de Tullio P; Becker B; Boverie S; Dabrowski M; Wahl P; Antoine MH; Somers F; Sebille S; Ouedraogo R; Hansen JB; Lebrun P; Pirotte B
    J Med Chem; 2003 Jul; 46(15):3342-53. PubMed ID: 12852765
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis, and pharmacological evaluation of R/S-3,4-dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: toward tissue-selective pancreatic beta-cell KATP channel openers structurally related to (+/-)-cromakalim.
    Sebille S; Gall D; de Tullio P; Florence X; Lebrun P; Pirotte B
    J Med Chem; 2006 Jul; 49(15):4690-7. PubMed ID: 16854075
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and characterization of a quinolinonic compound activating ATP-sensitive K(+) channels in endocrine and smooth muscle tissues.
    Becker B; Antoine MH; Nguyen QA; Rigo B; Cosgrove KE; Barnes PD; Dunne MJ; Pirotte B; Lebrun P
    Br J Pharmacol; 2001 Sep; 134(2):375-85. PubMed ID: 11564656
    [TBL] [Abstract][Full Text] [Related]  

  • 15. KATP channel openers: tissue selectivity of original 3-alkylaminopyrido- and 3-alkylaminobenzothiadiazine 1,1-dioxides.
    Lebrun P; Becker B; Morel N; Ghisdal P; Antoine MH; de Tullio P; Pirotte B
    Biochem Pharmacol; 2008 Jan; 75(2):468-75. PubMed ID: 17920043
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 3-and 4-substituted 4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potassium channel openers: synthesis, pharmacological evaluation, and structure-activity relationships.
    de Tullio P; Pirotte B; Lebrun P; Fontaine J; Dupont L; Antoine MH; Ouedraogo R; Khelili S; Maggetto C; Masereel B; Diouf O; Podona T; Delarge J
    J Med Chem; 1996 Feb; 39(4):937-48. PubMed ID: 8632417
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.
    Pirotte B; de Tullio P; Nguyen QA; Somers F; Fraikin P; Florence X; Wahl P; Hansen JB; Lebrun P
    J Med Chem; 2010 Jan; 53(1):147-54. PubMed ID: 19919106
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells.
    Khelili S; Kihal N; Yekhlef M; de Tullio P; Lebrun P; Pirotte B
    Eur J Med Chem; 2012 Aug; 54():873-8. PubMed ID: 22647221
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release.
    Tagmose TM; Schou SC; Mogensen JP; Nielsen FE; Arkhammar PO; Wahl P; Hansen BS; Worsaae A; Boonen HC; Antoine MH; Lebrun P; Hansen JB
    J Med Chem; 2004 Jun; 47(12):3202-11. PubMed ID: 15163199
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Glitazones exert multiple effects on β-cell stimulus-secretion coupling.
    Düfer M; Noack K; Edalat A; Krippeit-Drews P; Drews G
    Mol Pharmacol; 2013 Jan; 83(1):51-60. PubMed ID: 23024191
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.