BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

208 related articles for article (PubMed ID: 28971610)

  • 1. Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine.
    Elsby R; Chidlaw S; Outteridge S; Pickering S; Radcliffe A; Sullivan R; Jones H; Butler P
    Pharmacol Res Perspect; 2017 Oct; 5(5):. PubMed ID: 28971610
    [TBL] [Abstract][Full Text] [Related]  

  • 2. N(1)-methylnicotinamide as an endogenous probe for drug interactions by renal cation transporters: studies on the metformin-trimethoprim interaction.
    Müller F; Pontones CA; Renner B; Mieth M; Hoier E; Auge D; Maas R; Zolk O; Fromm MF
    Eur J Clin Pharmacol; 2015 Jan; 71(1):85-94. PubMed ID: 25552403
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.
    Ito S; Kusuhara H; Yokochi M; Toyoshima J; Inoue K; Yuasa H; Sugiyama Y
    J Pharmacol Exp Ther; 2012 Feb; 340(2):393-403. PubMed ID: 22072731
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Role of organic cation transporter OCT2 and multidrug and toxin extrusion proteins MATE1 and MATE2-K for transport and drug interactions of the antiviral lamivudine.
    Müller F; König J; Hoier E; Mandery K; Fromm MF
    Biochem Pharmacol; 2013 Sep; 86(6):808-15. PubMed ID: 23876341
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate).
    Ceckova M; Reznicek J; Deutsch B; Fromm MF; Staud F
    PLoS One; 2018; 13(8):e0202706. PubMed ID: 30114293
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug-drug interactions.
    Burt HJ; Neuhoff S; Almond L; Gaohua L; Harwood MD; Jamei M; Rostami-Hodjegan A; Tucker GT; Rowland-Yeo K
    Eur J Pharm Sci; 2016 Jun; 88():70-82. PubMed ID: 27019345
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The Nonmetabolized β-Blocker Nadolol Is a Substrate of OCT1, OCT2, MATE1, MATE2-K, and P-Glycoprotein, but Not of OATP1B1 and OATP1B3.
    Misaka S; Knop J; Singer K; Hoier E; Keiser M; Müller F; Glaeser H; König J; Fromm MF
    Mol Pharm; 2016 Feb; 13(2):512-9. PubMed ID: 26702643
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells.
    Tsuda M; Terada T; Ueba M; Sato T; Masuda S; Katsura T; Inui K
    J Pharmacol Exp Ther; 2009 Apr; 329(1):185-91. PubMed ID: 19164462
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Moxifloxacin Is a Potent In Vitro Inhibitor of OCT- and MATE-Mediated Transport of Metformin and Ethambutol.
    Te Brake LH; van den Heuvel JJ; Buaben AO; van Crevel R; Bilos A; Russel FG; Aarnoutse RE; Koenderink JB
    Antimicrob Agents Chemother; 2016 Dec; 60(12):7105-7114. PubMed ID: 27645247
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Effect of Cimetidine on Metformin Pharmacokinetics and Endogenous Metabolite Levels in Rats.
    Ailabouni AS; Mettu VS; Thakur A; Singh DK; Prasad B
    Drug Metab Dispos; 2024 Jan; 52(2):86-94. PubMed ID: 38049999
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Impact of Substrate-Dependent Inhibition on Renal Organic Cation Transporters hOCT2 and hMATE1/2-K-Mediated Drug Transport and Intracellular Accumulation.
    Yin J; Duan H; Wang J
    J Pharmacol Exp Ther; 2016 Dec; 359(3):401-410. PubMed ID: 27758931
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs).
    Li Q; Guo D; Dong Z; Zhang W; Zhang L; Huang SM; Polli JE; Shu Y
    Toxicol Appl Pharmacol; 2013 Nov; 273(1):100-9. PubMed ID: 24001450
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation.
    Shen H; Liu T; Jiang H; Titsch C; Taylor K; Kandoussi H; Qiu X; Chen C; Sukrutharaj S; Kuit K; Mintier G; Krishnamurthy P; Fancher RM; Zeng J; Rodrigues AD; Marathe P; Lai Y
    Drug Metab Dispos; 2016 Feb; 44(2):238-49. PubMed ID: 26608080
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Trimethoprim-metformin interaction and its genetic modulation by OCT2 and MATE1 transporters.
    Grün B; Kiessling MK; Burhenne J; Riedel KD; Weiss J; Rauch G; Haefeli WE; Czock D
    Br J Clin Pharmacol; 2013 Nov; 76(5):787-96. PubMed ID: 23305245
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure.
    Elsby R; Martin P; Surry D; Sharma P; Fenner K
    Drug Metab Dispos; 2016 Mar; 44(3):398-408. PubMed ID: 26700956
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Use of a Double-Transfected System to Predict hOCT2/hMATE1-Mediated Renal Drug-Drug Interactions.
    Vieira LS; Wang J
    Drug Metab Dispos; 2024 Mar; 52(4):296-304. PubMed ID: 38326034
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The Use of Transporter Probe Drug Cocktails for the Assessment of Transporter-Based Drug-Drug Interactions in a Clinical Setting-Proposal of a Four Component Transporter Cocktail.
    Ebner T; Ishiguro N; Taub ME
    J Pharm Sci; 2015 Sep; 104(9):3220-8. PubMed ID: 25981193
    [TBL] [Abstract][Full Text] [Related]  

  • 18. N-methylnicotinamide is an endogenous probe for evaluation of drug-drug interactions involving multidrug and toxin extrusions (MATE1 and MATE2-K).
    Ito S; Kusuhara H; Kumagai Y; Moriyama Y; Inoue K; Kondo T; Nakayama H; Horita S; Tanabe K; Yuasa H; Sugiyama Y
    Clin Pharmacol Ther; 2012 Nov; 92(5):635-41. PubMed ID: 23047651
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Significance of Organic Anion Transporter 2 and Organic Cation Transporter 2 in Creatinine Clearance: Mechanistic Evaluation Using Freshly Prepared Human Primary Renal Proximal Tubule Cells.
    Mathialagan S; Chung G; Pye K; Rodrigues AD; Varma MVS; Brown C
    J Pharmacol Exp Ther; 2024 Jan; 388(1):201-208. PubMed ID: 37977812
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1).
    Lai Y; Sampson KE; Balogh LM; Brayman TG; Cox SR; Adams WJ; Kumar V; Stevens JC
    J Pharmacol Exp Ther; 2010 Sep; 334(3):936-44. PubMed ID: 20519552
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.