These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

187 related articles for article (PubMed ID: 28988709)

  • 1. Identification and characterization of a potent and selective inhibitor of human urate transporter 1.
    Wu T; Chen J; Dong S; Li H; Cao Y; Tian Y; Fu W; Zhou P; Xi B; Pang J
    Pharmacol Rep; 2017 Oct; 69(5):1103-1112. PubMed ID: 28988709
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells.
    Yu Z; Fong WP; Cheng CH
    Drug Metab Dispos; 2007 Jun; 35(6):981-6. PubMed ID: 17325024
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of Flexible Naphthyltriazolylmethane-based Thioacetic Acids as Highly Active Uric Acid Transporter 1 (URAT1) Inhibitors for the Treatment of Hyperuricemia of Gout.
    Zhang X; Wu J; Liu W; Liu Y; Xie Y; Shang Q; Zhou Z; Xu W; Tang L; Wang J; Zhao G
    Med Chem; 2017; 13(3):260-281. PubMed ID: 27633583
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers.
    Yang C; Zhou D; Shen Z; Wilson DM; Renner M; Miner JN; Girardet JL; Lee CA
    Drug Metab Dispos; 2019 Feb; 47(2):104-113. PubMed ID: 30442650
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Anti-hyperuricemic effect of Alpinia oxyphylla seed extract by enhancing uric acid excretion in the kidney.
    Lee YS; Sung YY; Yuk HJ; Son E; Lee S; Kim JS; Kim DS
    Phytomedicine; 2019 Sep; 62():152975. PubMed ID: 31181404
    [TBL] [Abstract][Full Text] [Related]  

  • 6. [Molecular basis of primary renal hyperuricemia : role of the human urate transporter hURAT1].
    Unger S; Tausche AK; Kopprasch S; Bornstein SR; Aringer M; Grässler J
    Z Rheumatol; 2007 Nov; 66(7):556, 58-61. PubMed ID: 17891408
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Systematic Structure-Activity Relationship (SAR) Exploration of Diarylmethane Backbone and Discovery of A Highly Potent Novel Uric Acid Transporter 1 (URAT1) Inhibitor.
    Cai W; Wu J; Liu W; Xie Y; Liu Y; Zhang S; Xu W; Tang L; Wang J; Zhao G
    Molecules; 2018 Jan; 23(2):. PubMed ID: 29382075
    [TBL] [Abstract][Full Text] [Related]  

  • 8. CDER167, a dual inhibitor of URAT1 and GLUT9, is a novel and potent uricosuric candidate for the treatment of hyperuricemia.
    Zhao ZA; Jiang Y; Chen YY; Wu T; Lan QS; Li YM; Li L; Yang Y; Lin CT; Cao Y; Zhou PZ; Guo JY; Tian YX; Pang JX
    Acta Pharmacol Sin; 2022 Jan; 43(1):121-132. PubMed ID: 33767379
    [TBL] [Abstract][Full Text] [Related]  

  • 9. [Mangiferin promotes uric acid excretion and kidney function improvement and modulates related renal transporters in hyperuricemic mice].
    Hu QH; Zhang X; Wang Y; Kong LD
    Yao Xue Xue Bao; 2010 Oct; 45(10):1239-46. PubMed ID: 21348301
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pharmacological Evaluation of Dotinurad, a Selective Urate Reabsorption Inhibitor.
    Taniguchi T; Ashizawa N; Matsumoto K; Saito R; Motoki K; Sakai M; Chikamatsu N; Hagihara C; Hashiba M; Iwanaga T
    J Pharmacol Exp Ther; 2019 Oct; 371(1):162-170. PubMed ID: 31371478
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Novel natural scaffold as hURAT1 inhibitor identified by 3D-shape-based, docking-based virtual screening approach and biological evaluation.
    Chen X; Zhao Z; Luo J; Wu T; Shen Y; Chang S; Wan S; Li Z; Zhang J; Pang J; Tian Y
    Bioorg Chem; 2021 Dec; 117():105444. PubMed ID: 34775203
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Impact of Lesinurad and allopurinol on experimental Hyperuricemia in mice: biochemical, molecular and Immunohistochemical study.
    Alghamdi YS; Soliman MM; Nassan MA
    BMC Pharmacol Toxicol; 2020 Feb; 21(1):10. PubMed ID: 32041665
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Human uric acid transporter 1 (hURAT1): an inhibitor structure-activity relationship (SAR) study.
    Wempe MF; Quade B; Jutabha P; Iwen T; Frick M; Rice PJ; Wakui S; Endou H
    Nucleosides Nucleotides Nucleic Acids; 2011 Dec; 30(12):1312-23. PubMed ID: 22132992
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney.
    Miner JN; Tan PK; Hyndman D; Liu S; Iverson C; Nanavati P; Hagerty DT; Manhard K; Shen Z; Girardet JL; Yeh LT; Terkeltaub R; Quart B
    Arthritis Res Ther; 2016 Oct; 18(1):214. PubMed ID: 27716403
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice.
    Hu QH; Zhang X; Wang X; Jiao RQ; Kong LD
    Eur J Nutr; 2012 Aug; 51(5):593-606. PubMed ID: 21909718
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Total saponins from Discorea nipponica ameliorate urate excretion in hyperuricemic mice.
    Zhou Q; Yu DH; Zhang C; Liu SM; Lu F
    Planta Med; 2014 Oct; 80(15):1259-68. PubMed ID: 25248048
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability.
    Zhao T; Meng Q; Sun Z; Chen Y; Ai W; Zhao Z; Kang D; Dong Y; Liang R; Wu T; Pang J; Liu X; Zhan P
    J Med Chem; 2020 Oct; 63(19):10829-10854. PubMed ID: 32897699
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and evaluation of sulfonamide derivatives as potent Human Uric Acid Transporter 1 (hURAT1) inhibitors.
    Yang X; Pang X; Fan L; Li X; Chen Y
    Bioorg Med Chem Lett; 2017 May; 27(9):1919-1922. PubMed ID: 28351592
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia.
    Zhang Y; Jin L; Liu J; Wang W; Yu H; Li J; Chen Q; Wang T
    J Ethnopharmacol; 2018 Mar; 214():29-36. PubMed ID: 29233733
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of a Novel Thienopyrimidine Compound as a Urate Transporter 1 and Glucose Transporter 9 Dual Inhibitor with Improved Efficacy and Favorable Druggability.
    Shi X; Zhao T; Wang S; Xu S; Liao H; Gao S; Gao Z; Zhang J; Qi D; Zhang Z; Zheng F; Wang Y; Wang Z; Yang M; Yang Q; Yi F; Pang J; Liu X; Zhan P
    J Med Chem; 2024 Mar; 67(6):5032-5052. PubMed ID: 38482820
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.