BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

139 related articles for article (PubMed ID: 29019402)

  • 21. Discovery of novel Pim-1 kinase inhibitors by a hierarchical multistage virtual screening approach based on SVM model, pharmacophore, and molecular docking.
    Ren JX; Li LL; Zheng RL; Xie HZ; Cao ZX; Feng S; Pan YL; Chen X; Wei YQ; Yang SY
    J Chem Inf Model; 2011 Jun; 51(6):1364-75. PubMed ID: 21618971
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors.
    Pastor J; Oyarzabal J; Saluste G; Alvarez RM; Rivero V; Ramos F; Cendón E; Blanco-Aparicio C; Ajenjo N; Cebriá A; Albarrán MI; Cebrián D; Corrionero A; Fominaya J; Montoya G; Mazzorana M
    Bioorg Med Chem Lett; 2012 Feb; 22(4):1591-7. PubMed ID: 22266039
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Thermodynamic Characterization of Hydration Sites from Integral Equation-Derived Free Energy Densities: Application to Protein Binding Sites and Ligand Series.
    Güssregen S; Matter H; Hessler G; Lionta E; Heil J; Kast SM
    J Chem Inf Model; 2017 Jul; 57(7):1652-1666. PubMed ID: 28565907
    [TBL] [Abstract][Full Text] [Related]  

  • 24. An attempt to incorporate effect of direct interaction between a ligand and explicit water molecules into MM/3D-RISM.
    Gohda K
    Chem Biol Drug Des; 2018 Oct; 92(4):1788-1800. PubMed ID: 29962020
    [TBL] [Abstract][Full Text] [Related]  

  • 25. A novel Pim-1 kinase inhibitor targeting residues that bind the substrate peptide.
    Tsuganezawa K; Watanabe H; Parker L; Yuki H; Taruya S; Nakagawa Y; Kamei D; Mori M; Ogawa N; Tomabechi Y; Handa N; Honma T; Yokoyama S; Kojima H; Okabe T; Nagano T; Tanaka A
    J Mol Biol; 2012 Mar; 417(3):240-52. PubMed ID: 22306408
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Understanding the Liquid States of Cyclic Hydrocarbons Containing N, O, and S Atoms via the 3D-RISM-KH Molecular Solvation Theory.
    Roy D; Kovalenko A
    Molecules; 2022 Oct; 27(19):. PubMed ID: 36235097
    [TBL] [Abstract][Full Text] [Related]  

  • 27. What doesn't fit is made to fit: Pim-1 kinase adapts to the configuration of stilbene-based inhibitors.
    Hochban PMM; Heyder L; Heine A; Diederich WE
    Arch Pharm (Weinheim); 2024 Jun; 357(6):e2400094. PubMed ID: 38631036
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I.
    Barberis C; Moorcroft N; Arendt C; Levit M; Moreno-Mazza S; Batchelor J; Mechin I; Majid T
    Bioorg Med Chem Lett; 2017 Oct; 27(20):4730-4734. PubMed ID: 28947155
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors.
    Gavara L; Suchaud V; Nauton L; Théry V; Anizon F; Moreau P
    Bioorg Med Chem Lett; 2013 Apr; 23(8):2298-301. PubMed ID: 23499503
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Design and synthesis of substituted pyrido[3,2-d]-1,2,3-triazines as potential Pim-1 inhibitors.
    Fan YB; Li K; Huang M; Cao Y; Li Y; Jin SY; Liu WB; Wen JC; Liu D; Zhao LX
    Bioorg Med Chem Lett; 2016 Feb; 26(4):1224-8. PubMed ID: 26804231
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Use of regulators and inhibitors of Pim-1, a serine/threonine kinase, for tumour therapy (review).
    Liang C; Li YY
    Mol Med Rep; 2014 Jun; 9(6):2051-60. PubMed ID: 24737044
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design.
    Wang X; Magnuson S; Pastor R; Fan E; Hu H; Tsui V; Deng W; Murray J; Steffek M; Wallweber H; Moffat J; Drummond J; Chan G; Harstad E; Ebens AJ
    Bioorg Med Chem Lett; 2013 Jun; 23(11):3149-53. PubMed ID: 23623490
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Computational analysis of benzofuran-2-carboxlic acids as potent Pim-1 kinase inhibitors.
    Wadood A; Jamal SB; Riaz M; Mir A
    Pharm Biol; 2014 Sep; 52(9):1170-8. PubMed ID: 24766364
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Exploiting the repertoire of CK2 inhibitors to target DYRK and PIM kinases.
    Cozza G; Sarno S; Ruzzene M; Girardi C; Orzeszko A; Kazimierczuk Z; Zagotto G; Bonaiuto E; Di Paolo ML; Pinna LA
    Biochim Biophys Acta; 2013 Jul; 1834(7):1402-9. PubMed ID: 23360763
    [TBL] [Abstract][Full Text] [Related]  

  • 35. MTS-MD of Biomolecules Steered with 3D-RISM-KH Mean Solvation Forces Accelerated with Generalized Solvation Force Extrapolation.
    Omelyan I; Kovalenko A
    J Chem Theory Comput; 2015 Apr; 11(4):1875-95. PubMed ID: 26574393
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification - Part II.
    Barberis C; Moorcroft N; Pribish J; Tserlin E; Gross A; Czekaj M; Barrague M; Erdman P; Majid T; Batchelor J; Levit M; Hebert A; Shen L; Moreno-Mazza S; Wang A
    Bioorg Med Chem Lett; 2017 Oct; 27(20):4735-4740. PubMed ID: 28927793
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: a template-based approach.
    Dwyer MP; Keertikar K; Paruch K; Alvarez C; Labroli M; Poker C; Fischmann TO; Mayer-Ezell R; Bond R; Wang Y; Azevedo R; Guzi TJ
    Bioorg Med Chem Lett; 2013 Nov; 23(22):6178-82. PubMed ID: 24091081
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Ligand mapping on protein surfaces by the 3D-RISM theory: toward computational fragment-based drug design.
    Imai T; Oda K; Kovalenko A; Hirata F; Kidera A
    J Am Chem Soc; 2009 Sep; 131(34):12430-40. PubMed ID: 19655800
    [TBL] [Abstract][Full Text] [Related]  

  • 39. The design, synthesis, and biological evaluation of PIM kinase inhibitors.
    Tsuhako AL; Brown DS; Koltun ES; Aay N; Arcalas A; Chan V; Du H; Engst S; Franzini M; Galan A; Huang P; Johnston S; Kane B; Kim MH; Laird AD; Lin R; Mock L; Ngan I; Pack M; Stott G; Stout TJ; Yu P; Zaharia C; Zhang W; Zhou P; Nuss JM; Kearney PC; Xu W
    Bioorg Med Chem Lett; 2012 Jun; 22(11):3732-8. PubMed ID: 22542012
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors.
    Wu B; Wang HL; Cee VJ; Lanman BA; Nixey T; Pettus L; Reed AB; Wurz RP; Guerrero N; Sastri C; Winston J; Lipford JR; Lee MR; Mohr C; Andrews KL; Tasker AS
    Bioorg Med Chem Lett; 2015 Feb; 25(4):775-80. PubMed ID: 25616902
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.