285 related articles for article (PubMed ID: 29033317)
1. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.
Gentile DR; Rathinaswamy MK; Jenkins ML; Moss SM; Siempelkamp BD; Renslo AR; Burke JE; Shokat KM
Cell Chem Biol; 2017 Dec; 24(12):1455-1466.e14. PubMed ID: 29033317
[TBL] [Abstract][Full Text] [Related]
2. Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras.
Xu S; Long BN; Boris GH; Chen A; Ni S; Kennedy MA
Acta Crystallogr D Struct Biol; 2017 Dec; 73(Pt 12):970-984. PubMed ID: 29199977
[TBL] [Abstract][Full Text] [Related]
3. Structural basis for conformational dynamics of GTP-bound Ras protein.
Shima F; Ijiri Y; Muraoka S; Liao J; Ye M; Araki M; Matsumoto K; Yamamoto N; Sugimoto T; Yoshikawa Y; Kumasaka T; Yamamoto M; Tamura A; Kataoka T
J Biol Chem; 2010 Jul; 285(29):22696-705. PubMed ID: 20479006
[TBL] [Abstract][Full Text] [Related]
4. GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.
Lu S; Banerjee A; Jang H; Zhang J; Gaponenko V; Nussinov R
J Biol Chem; 2015 Nov; 290(48):28887-900. PubMed ID: 26453300
[TBL] [Abstract][Full Text] [Related]
5. Comparison of ras-p21 bound to GDP and GTP: differences in protein and ligand dynamics.
Mello LV; van Aalten DM; Findlay JB
Protein Eng; 1997 Apr; 10(4):381-7. PubMed ID: 9194162
[TBL] [Abstract][Full Text] [Related]
6. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
Ostrem JM; Peters U; Sos ML; Wells JA; Shokat KM
Nature; 2013 Nov; 503(7477):548-51. PubMed ID: 24256730
[TBL] [Abstract][Full Text] [Related]
7. In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.
Hunter JC; Gurbani D; Ficarro SB; Carrasco MA; Lim SM; Choi HG; Xie T; Marto JA; Chen Z; Gray NS; Westover KD
Proc Natl Acad Sci U S A; 2014 Jun; 111(24):8895-900. PubMed ID: 24889603
[TBL] [Abstract][Full Text] [Related]
8. Design of Small Molecules That Compete with Nucleotide Binding to an Engineered Oncogenic KRAS Allele.
Zhang Y; Larraufie MH; Musavi L; Akkiraju H; Brown LM; Stockwell BR
Biochemistry; 2018 Feb; 57(8):1380-1389. PubMed ID: 29313669
[TBL] [Abstract][Full Text] [Related]
9. Conformational Dynamics Allows Sampling of an "Active-like" State by Oncogenic K-Ras-GDP.
Grudzien P; Jang H; Leschinsky N; Nussinov R; Gaponenko V
J Mol Biol; 2022 Sep; 434(17):167695. PubMed ID: 35752212
[TBL] [Abstract][Full Text] [Related]
10. The higher level of complexity of K-Ras4B activation at the membrane.
Jang H; Banerjee A; Chavan TS; Lu S; Zhang J; Gaponenko V; Nussinov R
FASEB J; 2016 Apr; 30(4):1643-55. PubMed ID: 26718888
[TBL] [Abstract][Full Text] [Related]
11. Crystal structures of Ral-GppNHp and Ral-GDP reveal two binding sites that are also present in Ras and Rap.
Nicely NI; Kosak J; de Serrano V; Mattos C
Structure; 2004 Nov; 12(11):2025-36. PubMed ID: 15530367
[TBL] [Abstract][Full Text] [Related]
12. Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis.
Spoerner M; Hozsa C; Poetzl JA; Reiss K; Ganser P; Geyer M; Kalbitzer HR
J Biol Chem; 2010 Dec; 285(51):39768-78. PubMed ID: 20937837
[TBL] [Abstract][Full Text] [Related]
13. Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence.
Vo U; Vajpai N; Flavell L; Bobby R; Breeze AL; Embrey KJ; Golovanov AP
J Biol Chem; 2016 Jan; 291(4):1703-1718. PubMed ID: 26565026
[TBL] [Abstract][Full Text] [Related]
14. Dynamic studies of H-Ras•GTPγS interactions with nucleotide exchange factor Sos reveal a transient ternary complex formation in solution.
Vo U; Vajpai N; Embrey KJ; Golovanov AP
Sci Rep; 2016 Jul; 6():29706. PubMed ID: 27412770
[TBL] [Abstract][Full Text] [Related]
15. Raman difference studies of GDP and GTP binding to c-Harvey ras.
Wang JH; Xiao DG; Deng H; Webb MR; Callender R
Biochemistry; 1998 Aug; 37(31):11106-16. PubMed ID: 9693007
[TBL] [Abstract][Full Text] [Related]
16. Mechanism of the guanine nucleotide exchange reaction of Ras GTPase--evidence for a GTP/GDP displacement model.
Zhang B; Zhang Y; Shacter E; Zheng Y
Biochemistry; 2005 Feb; 44(7):2566-76. PubMed ID: 15709769
[TBL] [Abstract][Full Text] [Related]
17. Electrostatic control of GTP and GDP binding in the oncoprotein p21ras.
Muegge I; Schweins T; Langen R; Warshel A
Structure; 1996 Apr; 4(4):475-89. PubMed ID: 8740369
[TBL] [Abstract][Full Text] [Related]
18. An NMR comparison of the changes produced by different guanosine 5'-triphosphate analogs in wild-type and oncogenic mutant p21ras.
Miller AF; Halkides CJ; Redfield AG
Biochemistry; 1993 Jul; 32(29):7367-76. PubMed ID: 8338834
[TBL] [Abstract][Full Text] [Related]
19. Calculation of pathways for the conformational transition between the GTP- and GDP-bound states of the Ha-ras-p21 protein: calculations with explicit solvent simulations and comparison with calculations in vacuum.
Diaz JF; Wroblowski B; Schlitter J; Engelborghs Y
Proteins; 1997 Jul; 28(3):434-51. PubMed ID: 9223188
[TBL] [Abstract][Full Text] [Related]
20. Mutant-Specific Targeting of Ras G12C Activity by Covalently Reacting Small Molecules.
Goody RS; Müller MP; Rauh D
Cell Chem Biol; 2019 Oct; 26(10):1338-1348. PubMed ID: 31378709
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]