BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

249 related articles for article (PubMed ID: 29044141)

  • 1. Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage.
    Bačević K; Lossaint G; Achour TN; Georget V; Fisher D; Dulić V
    Sci Rep; 2017 Oct; 7(1):13429. PubMed ID: 29044141
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional.
    Lossaint G; Besnard E; Fisher D; Piette J; Dulić V
    Oncogene; 2011 Oct; 30(41):4261-74. PubMed ID: 21532626
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase.
    Sakurikar N; Thompson R; Montano R; Eastman A
    Oncotarget; 2016 Jan; 7(2):1380-94. PubMed ID: 26595527
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Reciprocal regulation of p21 and Chk1 controls the cyclin D1-RB pathway to mediate senescence onset after G2 arrest.
    Lossaint G; Horvat A; Gire V; Bačević K; Mrouj K; Charrier-Savournin F; Georget V; Fisher D; Dulić V
    J Cell Sci; 2022 Apr; 135(8):. PubMed ID: 35343565
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cdk2 is required for p53-independent G2/M checkpoint control.
    Chung JH; Bunz F
    PLoS Genet; 2010 Feb; 6(2):e1000863. PubMed ID: 20195506
    [TBL] [Abstract][Full Text] [Related]  

  • 6. CDK4 inhibition restores G(1)-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage.
    Gogolin S; Ehemann V; Becker G; Brueckner LM; Dreidax D; Bannert S; Nolte I; Savelyeva L; Bell E; Westermann F
    Cell Cycle; 2013 Apr; 12(7):1091-104. PubMed ID: 23462184
    [TBL] [Abstract][Full Text] [Related]  

  • 7. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.
    Neganova I; Vilella F; Atkinson SP; Lloret M; Passos JF; von Zglinicki T; O'Connor JE; Burks D; Jones R; Armstrong L; Lako M
    Stem Cells; 2011 Apr; 29(4):651-9. PubMed ID: 21319273
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The impact of S- and G2-checkpoint response on the fidelity of G1-arrest by cisplatin and its comparison to a non-cross-resistant platinum(IV) analog.
    He G; Kuang J; Khokhar AR; Siddik ZH
    Gynecol Oncol; 2011 Aug; 122(2):402-9. PubMed ID: 21592546
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase.
    Müllers E; Silva Cascales H; Jaiswal H; Saurin AT; Lindqvist A
    Cell Cycle; 2014; 13(17):2733-43. PubMed ID: 25486360
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints.
    Xie G; Habbersett RC; Jia Y; Peterson SR; Lehnert BE; Bradbury EM; D'Anna JA
    Oncogene; 1998 Feb; 16(6):721-36. PubMed ID: 9488036
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities.
    He G; Siddik ZH; Huang Z; Wang R; Koomen J; Kobayashi R; Khokhar AR; Kuang J
    Oncogene; 2005 Apr; 24(18):2929-43. PubMed ID: 15735718
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Chk1 and Wee1 control genotoxic-stress induced G2-M arrest in melanoma cells.
    Vera J; Raatz Y; Wolkenhauer O; Kottek T; Bhattacharya A; Simon JC; Kunz M
    Cell Signal; 2015 May; 27(5):951-60. PubMed ID: 25683911
    [TBL] [Abstract][Full Text] [Related]  

  • 13. p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress.
    Tudzarova S; Mulholland P; Dey A; Stoeber K; Okorokov AL; Williams GH
    Cell Cycle; 2016 Nov; 15(21):2958-2972. PubMed ID: 27611229
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Residual Cdk1/2 activity after DNA damage promotes senescence.
    Müllers E; Silva Cascales H; Burdova K; Macurek L; Lindqvist A
    Aging Cell; 2017 Jun; 16(3):575-584. PubMed ID: 28345297
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cdk-mediated phosphorylation of Chk1 is required for efficient activation and full checkpoint proficiency in response to DNA damage.
    Xu N; Libertini S; Black EJ; Lao Y; Hegarat N; Walker M; Gillespie DA
    Oncogene; 2012 Mar; 31(9):1086-94. PubMed ID: 21765472
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Sterigmatocystin induces G1 arrest in primary human esophageal epithelial cells but induces G2 arrest in immortalized cells: key mechanistic differences in these two models.
    Wang J; Huang S; Xing L; Cui J; Tian Z; Shen H; Jiang X; Yan X; Wang J; Zhang X
    Arch Toxicol; 2015 Nov; 89(11):2015-25. PubMed ID: 25294323
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Loss of p53 induces M-phase retardation following G2 DNA damage checkpoint abrogation.
    Minemoto Y; Uchida S; Ohtsubo M; Shimura M; Sasagawa T; Hirata M; Nakagama H; Ishizaka Y; Yamashita K
    Arch Biochem Biophys; 2003 Apr; 412(1):13-9. PubMed ID: 12646262
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe.
    Warren NJH; Eastman A
    J Biol Chem; 2019 Feb; 294(6):1763-1778. PubMed ID: 30573684
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phenoxodiol, a novel isoflavone, induces G1 arrest by specific loss in cyclin-dependent kinase 2 activity by p53-independent induction of p21WAF1/CIP1.
    Aguero MF; Facchinetti MM; Sheleg Z; Senderowicz AM
    Cancer Res; 2005 Apr; 65(8):3364-73. PubMed ID: 15833870
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication.
    Zhao H; Chen X; Gurian-West M; Roberts JM
    Mol Cell Biol; 2012 Apr; 32(8):1421-32. PubMed ID: 22331465
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.