BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

370 related articles for article (PubMed ID: 29046435)

  • 1. Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.
    Xiong Y; Walker K; Min X; Hale C; Tran T; Komorowski R; Yang J; Davda J; Nuanmanee N; Kemp D; Wang X; Liu H; Miller S; Lee KJ; Wang Z; Véniant MM
    Sci Transl Med; 2017 Oct; 9(412):. PubMed ID: 29046435
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity.
    Tsai VW; Zhang HP; Manandhar R; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Sainsbury A; Brown DA; Breit SN
    Int J Obes (Lond); 2018 Mar; 42(3):561-571. PubMed ID: 29026214
    [TBL] [Abstract][Full Text] [Related]  

  • 3. GDF15 acts synergistically with liraglutide but is not necessary for the weight loss induced by bariatric surgery in mice.
    Frikke-Schmidt H; Hultman K; Galaske JW; Jørgensen SB; Myers MG; Seeley RJ
    Mol Metab; 2019 Mar; 21():13-21. PubMed ID: 30685336
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.
    Emmerson PJ; Wang F; Du Y; Liu Q; Pickard RT; Gonciarz MD; Coskun T; Hamang MJ; Sindelar DK; Ballman KK; Foltz LA; Muppidi A; Alsina-Fernandez J; Barnard GC; Tang JX; Liu X; Mao X; Siegel R; Sloan JH; Mitchell PJ; Zhang BB; Gimeno RE; Shan B; Wu X
    Nat Med; 2017 Oct; 23(10):1215-1219. PubMed ID: 28846098
    [TBL] [Abstract][Full Text] [Related]  

  • 5. GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.
    Mullican SE; Lin-Schmidt X; Chin CN; Chavez JA; Furman JL; Armstrong AA; Beck SC; South VJ; Dinh TQ; Cash-Mason TD; Cavanaugh CR; Nelson S; Huang C; Hunter MJ; Rangwala SM
    Nat Med; 2017 Oct; 23(10):1150-1157. PubMed ID: 28846097
    [TBL] [Abstract][Full Text] [Related]  

  • 6. GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss.
    Borner T; Wald HS; Ghidewon MY; Zhang B; Wu Z; De Jonghe BC; Breen D; Grill HJ
    Cell Rep; 2020 Apr; 31(3):107543. PubMed ID: 32320650
    [TBL] [Abstract][Full Text] [Related]  

  • 7. GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS.
    Tsai VW; Zhang HP; Manandhar R; Schofield P; Christ D; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Brown DA; Breit SN
    Int J Obes (Lond); 2019 Dec; 43(12):2370-2380. PubMed ID: 31152154
    [TBL] [Abstract][Full Text] [Related]  

  • 8. GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
    Yang L; Chang CC; Sun Z; Madsen D; Zhu H; Padkjær SB; Wu X; Huang T; Hultman K; Paulsen SJ; Wang J; Bugge A; Frantzen JB; Nørgaard P; Jeppesen JF; Yang Z; Secher A; Chen H; Li X; John LM; Shan B; He Z; Gao X; Su J; Hansen KT; Yang W; Jørgensen SB
    Nat Med; 2017 Oct; 23(10):1158-1166. PubMed ID: 28846099
    [TBL] [Abstract][Full Text] [Related]  

  • 9. GDF15 deficiency promotes high fat diet-induced obesity in mice.
    Tran T; Yang J; Gardner J; Xiong Y
    PLoS One; 2018; 13(8):e0201584. PubMed ID: 30070999
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Camptothecin effectively treats obesity in mice through GDF15 induction.
    Lu JF; Zhu MQ; Xie BC; Shi XC; Liu H; Zhang RX; Xia B; Wu JW
    PLoS Biol; 2022 Feb; 20(2):e3001517. PubMed ID: 35202387
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets.
    Macia L; Tsai VW; Nguyen AD; Johnen H; Kuffner T; Shi YC; Lin S; Herzog H; Brown DA; Breit SN; Sainsbury A
    PLoS One; 2012; 7(4):e34868. PubMed ID: 22514681
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A long-acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese nonhuman primate model.
    Zheng S; Polidori D; Wang Y; Geist B; Lin-Schmidt X; Furman JL; Nelson S; Nawrocki AR; Hinke SA
    Clin Transl Sci; 2023 Aug; 16(8):1431-1444. PubMed ID: 37154518
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Prognostic value of circulating macrophage inhibitory cytokine 1-growth differentiation factor 15 (MIC-1/GDF15) in obesity: Relation with vascular endothelial growth factor (VEGF) and markers of oxidative stress.
    Parvaneh RR; Vajdi M; Shiraz AN; Khani M; Farshbaf SE; Farhangi MA
    Nutr Health; 2023 Dec; 29(4):707-713. PubMed ID: 35549472
    [No Abstract]   [Full Text] [Related]  

  • 14. A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys.
    Stanislaus S; Hecht R; Yie J; Hager T; Hall M; Spahr C; Wang W; Weiszmann J; Li Y; Deng L; Winters D; Smith S; Zhou L; Li Y; Véniant MM; Xu J
    Endocrinology; 2017 May; 158(5):1314-1327. PubMed ID: 28324011
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates.
    Zhang Y; Zhao X; Dong X; Zhang Y; Zou H; Jin Y; Guo W; Zhai P; Chen X; Kharitonenkov A
    Cell Metab; 2023 Feb; 35(2):287-298.e4. PubMed ID: 36706758
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract.
    Tsai VW; Manandhar R; Jørgensen SB; Lee-Ng KK; Zhang HP; Marquis CP; Jiang L; Husaini Y; Lin S; Sainsbury A; Sawchenko PE; Brown DA; Breit SN
    PLoS One; 2014; 9(6):e100370. PubMed ID: 24971956
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis.
    Guo X; Asthana P; Zhai L; Cheng KW; Gurung S; Huang J; Wu J; Zhang Y; Mahato AK; Saarma M; Ustav M; Kwan HY; Lyu A; Chan KM; Xu P; Bian ZX; Wong HLX
    Nat Commun; 2024 Feb; 15(1):1034. PubMed ID: 38310105
    [TBL] [Abstract][Full Text] [Related]  

  • 18. GDF15 Induces Anorexia through Nausea and Emesis.
    Borner T; Shaulson ED; Ghidewon MY; Barnett AB; Horn CC; Doyle RP; Grill HJ; Hayes MR; De Jonghe BC
    Cell Metab; 2020 Feb; 31(2):351-362.e5. PubMed ID: 31928886
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The Relationship between Metabolic Parameters, Cardiac Parameters and MIC-1/GDF15 in Obese Children.
    Yuca SA; Cimbek EA; Şen Y; Güvenç O; Vatansev H; Buğrul F; Gün F; Oran B
    Exp Clin Endocrinol Diabetes; 2017 Feb; 125(2):86-90. PubMed ID: 27750354
    [No Abstract]   [Full Text] [Related]  

  • 20. Increased Growth Differentiation Factor 15 in Patients with Hypoleptinemia-Associated Lipodystrophy.
    Kralisch S; Hoffmann A; Estrada-Kunz J; Stumvoll M; Fasshauer M; Tönjes A; Miehle K
    Int J Mol Sci; 2020 Sep; 21(19):. PubMed ID: 33003626
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 19.