308 related articles for article (PubMed ID: 29078389)
1. Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.
Zhou R; Yang G; Shi Y
Proc Natl Acad Sci U S A; 2017 Nov; 114(48):12731-12736. PubMed ID: 29078389
[TBL] [Abstract][Full Text] [Related]
2. Toward the structure of presenilin/γ-secretase and presenilin homologs.
Wolfe MS
Biochim Biophys Acta; 2013 Dec; 1828(12):2886-97. PubMed ID: 24099007
[TBL] [Abstract][Full Text] [Related]
3. Novel presenilin 1 and 2 double knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutations.
Pimenova AA; Goate AM
Neurobiol Dis; 2020 May; 138():104785. PubMed ID: 32032730
[TBL] [Abstract][Full Text] [Related]
4. Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.
Quintero-Monzon O; Martin MM; Fernandez MA; Cappello CA; Krzysiak AJ; Osenkowski P; Wolfe MS
Biochemistry; 2011 Oct; 50(42):9023-35. PubMed ID: 21919498
[TBL] [Abstract][Full Text] [Related]
5. Signature amyloid β profiles are produced by different γ-secretase complexes.
Acx H; Chávez-Gutiérrez L; Serneels L; Lismont S; Benurwar M; Elad N; De Strooper B
J Biol Chem; 2014 Feb; 289(7):4346-55. PubMed ID: 24338474
[TBL] [Abstract][Full Text] [Related]
6. Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
Yonemura Y; Futai E; Yagishita S; Kaether C; Ishiura S
Biochem Biophys Res Commun; 2016 Sep; 478(4):1751-7. PubMed ID: 27608597
[TBL] [Abstract][Full Text] [Related]
7. Human Presenilin-1 delivered by AAV9 rescues impaired γ-secretase activity, memory deficits, and neurodegeneration in
Montenegro P; Chen P; Kang J; Lee SH; Leone S; Shen J
Proc Natl Acad Sci U S A; 2023 Oct; 120(42):e2306714120. PubMed ID: 37816062
[TBL] [Abstract][Full Text] [Related]
8. Activation and intrinsic gamma-secretase activity of presenilin 1.
Ahn K; Shelton CC; Tian Y; Zhang X; Gilchrist ML; Sisodia SS; Li YM
Proc Natl Acad Sci U S A; 2010 Dec; 107(50):21435-40. PubMed ID: 21115843
[TBL] [Abstract][Full Text] [Related]
9. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
[TBL] [Abstract][Full Text] [Related]
10. Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.
Schmidt FC; Fitz K; Feilen LP; Okochi M; Steiner H; Langosch D
J Biol Chem; 2023 May; 299(5):104626. PubMed ID: 36944398
[TBL] [Abstract][Full Text] [Related]
11. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.
Yonemura Y; Futai E; Yagishita S; Suo S; Tomita T; Iwatsubo T; Ishiura S
J Biol Chem; 2011 Dec; 286(52):44569-75. PubMed ID: 22074918
[TBL] [Abstract][Full Text] [Related]
12. Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations.
Kim M; Bezprozvanny I
Int J Mol Sci; 2021 Dec; 22(24):. PubMed ID: 34948396
[TBL] [Abstract][Full Text] [Related]
13. Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity.
Moussavi Nik SH; Newman M; Wilson L; Ebrahimie E; Wells S; Musgrave I; Verdile G; Martins RN; Lardelli M
Hum Mol Genet; 2015 Jul; 24(13):3662-78. PubMed ID: 25814654
[TBL] [Abstract][Full Text] [Related]
14. Developing a Gene Therapy for the Treatment of Autosomal Dominant Alzheimer's Disease.
Moore B; Sharma A; Goulet M; Suter T; Pelletier C; Hu R; Schaeffer E; Kelleher RJ
Hum Gene Ther; 2023 Oct; 34(19-20):1049-1063. PubMed ID: 37578141
[TBL] [Abstract][Full Text] [Related]
15. Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis.
Islam S; Sun Y; Gao Y; Nakamura T; Noorani AA; Li T; Wong PC; Kimura N; Matsubara E; Kasuga K; Ikeuchi T; Tomita T; Zou K; Michikawa M
J Neurosci; 2022 Feb; 42(8):1574-1586. PubMed ID: 34987110
[TBL] [Abstract][Full Text] [Related]
16. Evidence For and Against a Pathogenic Role of Reduced γ-Secretase Activity in Familial Alzheimer's Disease.
Jayne T; Newman M; Verdile G; Sutherland G; Münch G; Musgrave I; Moussavi Nik SH; Lardelli M
J Alzheimers Dis; 2016 Apr; 52(3):781-99. PubMed ID: 27060961
[TBL] [Abstract][Full Text] [Related]
17. Knock-in rats with homozygous
Tambini MD; D'Adamio L
J Biol Chem; 2020 May; 295(21):7442-7451. PubMed ID: 32265300
[TBL] [Abstract][Full Text] [Related]
18. Assembly of the presenilin γ-/ε-secretase complex.
St George-Hyslop P; Fraser PE
J Neurochem; 2012 Jan; 120 Suppl 1():84-88. PubMed ID: 22122073
[TBL] [Abstract][Full Text] [Related]
19. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Pursglove SE; Ito A; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
J Biol Chem; 2004 Dec; 279(49):51654-60. PubMed ID: 15456764
[TBL] [Abstract][Full Text] [Related]
20. Structural basis of human γ-secretase assembly.
Sun L; Zhao L; Yang G; Yan C; Zhou R; Zhou X; Xie T; Zhao Y; Wu S; Li X; Shi Y
Proc Natl Acad Sci U S A; 2015 May; 112(19):6003-8. PubMed ID: 25918421
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
