BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

308 related articles for article (PubMed ID: 29096894)

  • 1. Experimental Therapy of Advanced Breast Cancer: Targeting NFAT1-MDM2-p53 Pathway.
    Qin JJ; Wang W; Zhang R
    Prog Mol Biol Transl Sci; 2017; 151():195-216. PubMed ID: 29096894
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inulanolide A as a new dual inhibitor of NFAT1-MDM2 pathway for breast cancer therapy.
    Qin JJ; Wang W; Sarkar S; Voruganti S; Agarwal R; Zhang R
    Oncotarget; 2016 May; 7(22):32566-78. PubMed ID: 27105525
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibiting NFAT1 for breast cancer therapy: New insights into the mechanism of action of MDM2 inhibitor JapA.
    Qin JJ; Wang W; Voruganti S; Wang H; Zhang WD; Zhang R
    Oncotarget; 2015 Oct; 6(32):33106-19. PubMed ID: 26461225
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Two Birds with One Stone: NFAT1-MDM2 Dual Inhibitors for Cancer Therapy.
    Wang W; Zafar A; Rajaei M; Zhang R
    Cells; 2020 May; 9(5):. PubMed ID: 32397368
    [TBL] [Abstract][Full Text] [Related]  

  • 5. MDM2-NFAT1 dual inhibitor, MA242: Effective against hepatocellular carcinoma, independent of p53.
    Wang W; Cheng JW; Qin JJ; Hu B; Li X; Nijampatnam B; Velu SE; Fan J; Yang XR; Zhang R
    Cancer Lett; 2019 Sep; 459():156-167. PubMed ID: 31181320
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy.
    Wang W; Qin JJ; Voruganti S; Nijampatnam B; Velu SE; Ruan KH; Hu M; Zhou J; Zhang R
    Cancer Res; 2018 Oct; 78(19):5656-5667. PubMed ID: 30217928
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Transcription factor NFAT1 activates the mdm2 oncogene independent of p53.
    Zhang X; Zhang Z; Cheng J; Li M; Wang W; Xu W; Wang H; Zhang R
    J Biol Chem; 2012 Aug; 287(36):30468-76. PubMed ID: 22787160
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of a new class of natural product MDM2 inhibitor: In vitro and in vivo anti-breast cancer activities and target validation.
    Qin JJ; Wang W; Voruganti S; Wang H; Zhang WD; Zhang R
    Oncotarget; 2015 Feb; 6(5):2623-40. PubMed ID: 25739118
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of lineariifolianoid A as a novel dual NFAT1 and MDM2 inhibitor for human cancer therapy.
    Qin JJ; Sarkar S; Voruganti S; Agarwal R; Wang W; Zhang R
    J Biomed Res; 2016 Jul; 30(4):322-33. PubMed ID: 27533941
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Induction of p53 expression and apoptosis by a recombinant dual-target MDM2/MDMX inhibitory protein in wild-type p53 breast cancer cells.
    Geng QQ; Dong DF; Chen NZ; Wu YY; Li EX; Wang J; Wang SM
    Int J Oncol; 2013 Dec; 43(6):1935-42. PubMed ID: 24126697
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Relationship and prognostic significance of phospho-(serine 166)-murine double minute 2 and Akt activation in node-negative breast cancer with regard to p53 expression.
    Schmitz KJ; Grabellus F; Callies R; Wohlschlaeger J; Otterbach F; Kimmig R; Levkau B; Schmid KW; Baba HA
    Virchows Arch; 2006 Jan; 448(1):16-23. PubMed ID: 16208531
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol inhibits MDM2 and induces apoptosis in breast cancer cells through a p53-independent pathway.
    Xu J; Han M; Shen J; Guan Q; Bai Z; Lang B; Zhang H; Li Z; Zuo D; Zhang W; Wu Y
    Cancer Lett; 2016 Dec; 383(1):9-17. PubMed ID: 27693458
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms.
    Wang H; Nan L; Yu D; Agrawal S; Zhang R
    Clin Cancer Res; 2001 Nov; 7(11):3613-24. PubMed ID: 11705884
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
    Li H; Liu Q; Wang Z; Fang R; Shen Y; Cai X; Gao Y; Li Y; Zhang X; Ye L
    J Biol Chem; 2015 Sep; 290(37):22649-61. PubMed ID: 26229107
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effects of MDM2 inhibitors on vascular endothelial growth factor-mediated tumor angiogenesis in human breast cancer.
    Xiong J; Yang Q; Li J; Zhou S
    Angiogenesis; 2014 Jan; 17(1):37-50. PubMed ID: 23907365
    [TBL] [Abstract][Full Text] [Related]  

  • 16. DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties.
    Soares J; Espadinha M; Raimundo L; Ramos H; Gomes AS; Gomes S; Loureiro JB; Inga A; Reis F; Gomes C; Santos MMM; Saraiva L
    Mol Oncol; 2017 Jun; 11(6):612-627. PubMed ID: 28296148
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Estrogen-activated MDM2 disrupts mammary tissue architecture through a p53-independent pathway.
    Kundu N; Brekman A; Kim JY; Xiao G; Gao C; Bargonetti J
    Oncotarget; 2017 Jul; 8(29):47916-47930. PubMed ID: 28615518
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells.
    Raza S; Ohm JE; Dhasarathy A; Schommer J; Roche C; Hammer KD; Ghribi O
    Mol Cell Biochem; 2015 Dec; 410(1-2):187-95. PubMed ID: 26350565
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Resistance acquisition to MDM2 inhibitors.
    Cinatl J; Speidel D; Hardcastle I; Michaelis M
    Biochem Soc Trans; 2014 Aug; 42(4):752-7. PubMed ID: 25109953
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function.
    Saxena R; Gupta G; Manohar M; Debnath U; Popli P; Prabhakar YS; Konwar R; Kumar S; Kumar A; Dwivedi A
    Int J Biochem Cell Biol; 2016 Jan; 70():105-17. PubMed ID: 26556313
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.