These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

119 related articles for article (PubMed ID: 29100801)

  • 1. Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1.
    Muthukaman N; Tambe M; Deshmukh S; Pisal D; Tondlekar S; Shaikh M; Sarode N; Kattige VG; Pisat M; Sawant P; Honnegowda S; Karande V; Kulkarni A; Behera D; Jadhav SB; Sangana RR; Gudi GS; Khairatkar-Joshi N; Gharat LA
    Bioorg Med Chem Lett; 2017 Dec; 27(23):5131-5138. PubMed ID: 29100801
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series - Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2.
    Muthukaman N; Deshmukh S; Tambe M; Pisal D; Tondlekar S; Shaikh M; Sarode N; Kattige VG; Sawant P; Pisat M; Karande V; Honnegowda S; Kulkarni A; Behera D; Jadhav SB; Sangana RR; Gudi GS; Khairatkar-Joshi N; Gharat LA
    Bioorg Med Chem Lett; 2018 Apr; 28(7):1211-1218. PubMed ID: 29519738
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E
    Muthukaman N; Tambe M; Shaikh M; Pisal D; Deshmukh S; Tondlekar S; Sarode N; Narayana L; Gajera JM; Kattige VG; Honnegowda S; Karande V; Kulkarni A; Behera D; Jadhav SB; Gudi GS; Khairatkar-Joshi N; Gharat LA
    Bioorg Med Chem Lett; 2017 Jun; 27(11):2594-2601. PubMed ID: 28400234
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E
    Muthukaman N; Deshmukh S; Sarode N; Tondlekar S; Tambe M; Pisal D; Shaikh M; Kattige VG; Honnegowda S; Karande V; Kulkarni A; Jadhav SB; Mahat MYA; Gudi GS; Khairatkar-Joshi N; Gharat LA
    Bioorg Med Chem Lett; 2016 Dec; 26(24):5977-5984. PubMed ID: 27865703
    [TBL] [Abstract][Full Text] [Related]  

  • 5. MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.
    Xu D; Rowland SE; Clark P; Giroux A; Côté B; Guiral S; Salem M; Ducharme Y; Friesen RW; Méthot N; Mancini J; Audoly L; Riendeau D
    J Pharmacol Exp Ther; 2008 Sep; 326(3):754-63. PubMed ID: 18524979
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.
    Giroux A; Boulet L; Brideau C; Chau A; Claveau D; Côté B; Ethier D; Frenette R; Gagnon M; Guay J; Guiral S; Mancini J; Martins E; Massé F; Méthot N; Riendeau D; Rubin J; Xu D; Yu H; Ducharme Y; Friesen RW
    Bioorg Med Chem Lett; 2009 Oct; 19(20):5837-41. PubMed ID: 19748780
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of N-amido-phenylsulfonamide derivatives as novel microsomal prostaglandin E
    Kim M; Kim G; Kang M; Ko D; Nam Y; Moon CS; Kang HM; Shin JS; Werz O; Lee KT; Lee JY
    Bioorg Med Chem Lett; 2021 Jun; 41():127992. PubMed ID: 33775835
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.
    Kuklish SL; Antonysamy S; Bhattachar SN; Chandrasekhar S; Fisher MJ; Fretland AJ; Gooding K; Harvey A; Hughes NE; Luz JG; Manninen PR; McGee JE; Navarro A; Norman BH; Partridge KM; Quimby SJ; Schiffler MA; Sloan AV; Warshawsky AM; York JS; Yu XP
    Bioorg Med Chem Lett; 2016 Oct; 26(19):4824-4828. PubMed ID: 27554445
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
    Côté B; Boulet L; Brideau C; Claveau D; Ethier D; Frenette R; Gagnon M; Giroux A; Guay J; Guiral S; Mancini J; Martins E; Massé F; Méthot N; Riendeau D; Rubin J; Xu D; Yu H; Ducharme Y; Friesen RW
    Bioorg Med Chem Lett; 2007 Dec; 17(24):6816-20. PubMed ID: 18029174
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of furo[3', 2':3,4]naphtho[1,2-d]imidazole derivatives as orally active and selective inhibitors of microsomal prostaglandin E(2) synthase-1 (mPGES-1).
    Tseng CH; Tzeng CC; Shih PK; Yang CN; Chuang YC; Peng SI; Lin CS; Wang JP; Cheng CM; Chen YL
    Mol Divers; 2012 May; 16(2):215-29. PubMed ID: 22161217
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Biological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone.
    Larsson K; Steinmetz J; Bergqvist F; Arefin S; Spahiu L; Wannberg J; Pawelzik SC; Morgenstern R; Stenberg P; Kublickiene K; Korotkova M; Jakobsson PJ
    Br J Pharmacol; 2019 Dec; 176(24):4625-4638. PubMed ID: 31404942
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 7-Phenyl-imidazoquinolin-4(5H)-one derivatives as selective and orally available mPGES-1 inhibitors.
    Shiro T; Kakiguchi K; Takahashi H; Nagata H; Tobe M
    Bioorg Med Chem; 2013 Jun; 21(11):2868-78. PubMed ID: 23623673
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.
    Koeberle A; Haberl EM; Rossi A; Pergola C; Dehm F; Northoff H; Troschuetz R; Sautebin L; Werz O
    Bioorg Med Chem; 2009 Dec; 17(23):7924-32. PubMed ID: 19884011
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.
    Partridge KM; Antonysamy S; Bhattachar SN; Chandrasekhar S; Fisher MJ; Fretland A; Gooding K; Harvey A; Hughes NE; Kuklish SL; Luz JG; Manninen PR; McGee JE; Mudra DR; Navarro A; Norman BH; Quimby SJ; Schiffler MA; Sloan AV; Warshawsky AM; Weller JM; York JS; Yu XP
    Bioorg Med Chem Lett; 2017 Mar; 27(6):1478-1483. PubMed ID: 28190634
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia.
    Chandrasekhar S; Harvey AK; Yu XP; Chambers MG; Oskins JL; Lin C; Seng TW; Thibodeaux SJ; Norman BH; Hughes NE; Schiffler MA; Fisher MJ
    J Pharmacol Exp Ther; 2016 Mar; 356(3):635-44. PubMed ID: 26740668
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis, and discovery of 5-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones and related derivatives as novel inhibitors of mPGES-1.
    Ding K; Zhou Z; Zhou S; Yuan Y; Kim K; Zhang T; Zheng X; Zheng F; Zhan CG
    Bioorg Med Chem Lett; 2018 Mar; 28(5):858-862. PubMed ID: 29456107
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis.
    Koppitz M; Bräuer N; Ter Laak A; Irlbacher H; Rotgeri A; Coelho AM; Walter D; Steinmeyer A; Zollner TM; Peters M; Nagel J
    Bioorg Med Chem Lett; 2019 Sep; 29(18):2700-2705. PubMed ID: 31362919
    [TBL] [