BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

159 related articles for article (PubMed ID: 29115478)

  • 1. Torin2 enhances the radiosensitivity of MCF‑7 breast cancer cells by downregulating the mTOR signaling pathway and ATM phosphorylation.
    Luo J; Pi G; Xiao H; Ye Y; Li Q; Zhao L; Huang H; Luo H; Zhang Q; Wang D; Wang G
    Mol Med Rep; 2018 Jan; 17(1):366-373. PubMed ID: 29115478
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.
    Liu Q; Xu C; Kirubakaran S; Zhang X; Hur W; Liu Y; Kwiatkowski NP; Wang J; Westover KD; Gao P; Ercan D; Niepel M; Thoreen CC; Kang SA; Patricelli MP; Wang Y; Tupper T; Altabef A; Kawamura H; Held KD; Chou DM; Elledge SJ; Janne PA; Wong KK; Sabatini DM; Gray NS
    Cancer Res; 2013 Apr; 73(8):2574-86. PubMed ID: 23436801
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Torin2 Potentiates Anticancer Effects on Adult T-Cell Leukemia/Lymphoma by Inhibiting Mammalian Target of Rapamycin.
    Watanabe T; Sato A; Kobayashi-Watanabe N; Sueoka-Aragane N; Kimura S; Sueoka E
    Anticancer Res; 2016 Jan; 36(1):95-102. PubMed ID: 26722032
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor is an effective radiosensitizer for colorectal cancer.
    Chen YH; Wei MF; Wang CW; Lee HW; Pan SL; Gao M; Kuo SH; Cheng AL; Teng CM
    Cancer Lett; 2015 Feb; 357(2):582-90. PubMed ID: 25497009
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis.
    Sadowski SM; Boufraqech M; Zhang L; Mehta A; Kapur P; Zhang Y; Li Z; Shen M; Kebebew E
    Oncotarget; 2015 Jul; 6(20):18038-49. PubMed ID: 25945839
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair.
    Udayakumar D; Pandita RK; Horikoshi N; Liu Y; Liu Q; Wong KK; Hunt CR; Gray NS; Minna JD; Pandita TK; Westover KD
    Radiat Res; 2016 May; 185(5):527-38. PubMed ID: 27135971
    [TBL] [Abstract][Full Text] [Related]  

  • 7. High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.
    Ahmed M; Hussain AR; Bavi P; Ahmed SO; Al Sobhi SS; Al-Dayel F; Uddin S; Al-Kuraya KS
    Carcinogenesis; 2014 Jul; 35(7):1564-72. PubMed ID: 24583924
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A study of sirolimus and mTOR kinase inhibitor in a hypomorphic
    Holditch SJ; Brown CN; Atwood DJ; Lombardi AM; Nguyen KN; Toll HW; Hopp K; Edelstein CL
    Am J Physiol Renal Physiol; 2019 Jul; 317(1):F187-F196. PubMed ID: 31042058
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mitochondrial Dysfunctions Regulated Radioresistance through Mitochondria-to-Nucleus Retrograde Signaling Pathway of NF-κB/PI3K/AKT2/mTOR.
    Wei Y; Chen L; Xu H; Xie C; Zhou Y; Zhou F
    Radiat Res; 2018 Aug; 190(2):204-215. PubMed ID: 29863983
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Curcumin enhances the response of non-Hodgkin's lymphoma cells to ionizing radiation through further induction of cell cycle arrest at the G2/M phase and inhibition of mTOR phosphorylation.
    Qiao Q; Jiang Y; Li G
    Oncol Rep; 2013 Jan; 29(1):380-6. PubMed ID: 23117293
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Targeting the mTOR pathway using novel ATP‑competitive inhibitors, Torin1, Torin2 and XL388, in the treatment of glioblastoma.
    Amin AG; Jeong SW; Gillick JL; Sursal T; Murali R; Gandhi CD; Jhanwar-Uniyal M
    Int J Oncol; 2021 Oct; 59(4):. PubMed ID: 34523696
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of Cisplatin in Epithelial Ovarian Cancer.
    Hussain AR; Al-Romaizan M; Ahmed M; Thangavel S; Al-Dayel F; Beg S; Uddin S; Siraj AK; Al-Kuraya KS
    Mol Med; 2015 May; 21(1):466-78. PubMed ID: 26023849
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Zerumbone Regulates DNA Repair Responding to Ionizing Radiation and Enhances Radiosensitivity of Human Prostatic Cancer Cells.
    Chiang PK; Tsai WK; Chen M; Lin WR; Chow YC; Lee CC; Hsu JM; Chen YJ
    Integr Cancer Ther; 2018 Jun; 17(2):292-298. PubMed ID: 28602099
    [TBL] [Abstract][Full Text] [Related]  

  • 14. RAD001 enhances the radiosensitivity of SCC4 oral cancer cells by inducing cell cycle arrest at the G2/M checkpoint.
    Yu CC; Hung SK; Liao HF; Lee CC; Lin HY; Lai HC; Li SC; Ho HC; Huang HB; Su YC
    Anticancer Res; 2014 Jun; 34(6):2927-35. PubMed ID: 24922656
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inactivation of mTor arrests bovine oocytes in the metaphase-I stage, despite reversible inhibition of 4E-BP1 phosphorylation.
    Mayer S; Wrenzycki C; Tomek W
    Mol Reprod Dev; 2014 Apr; 81(4):363-75. PubMed ID: 24459013
    [TBL] [Abstract][Full Text] [Related]  

  • 16. PARP inhibition induces Akt-mediated cytoprotective effects through the formation of a mitochondria-targeted phospho-ATM-NEMO-Akt-mTOR signalosome.
    Tapodi A; Bognar Z; Szabo C; Gallyas F; Sumegi B; Hocsak E
    Biochem Pharmacol; 2019 Apr; 162():98-108. PubMed ID: 30296409
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Ataxia-telangiectasia mutated (ATM) participates in the regulation of ionizing radiation-induced cell death via MAPK14 in lung cancer H1299 cells.
    Liang N; Zhong R; Hou X; Zhao G; Ma S; Cheng G; Liu X
    Cell Prolif; 2015 Oct; 48(5):561-72. PubMed ID: 26269117
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells.
    Chopra SS; Jenney A; Palmer A; Niepel M; Chung M; Mills C; Sivakumaren SC; Liu Q; Chen JY; Yapp C; Asara JM; Gray NS; Sorger PK
    Cell Syst; 2020 Jan; 10(1):66-81.e11. PubMed ID: 31812693
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells.
    Li JP; Yang YX; Liu QL; Pan ST; He ZX; Zhang X; Yang T; Chen XW; Wang D; Qiu JX; Zhou SF
    Drug Des Devel Ther; 2015; 9():1627-52. PubMed ID: 25834401
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Gambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactive oxygen species via targeting Akt/mTOR pathway.
    Yang Y; Sun X; Yang Y; Yang X; Zhu H; Dai S; Chen X; Zhang H; Guo Q; Song Y; Wang F; Cheng H; Sun X
    Tumour Biol; 2016 Feb; 37(2):1853-62. PubMed ID: 26318432
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.