BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

253 related articles for article (PubMed ID: 29117520)

  • 1. Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH
    Zhang M; Jang H; Gaponenko V; Nussinov R
    Biophys J; 2017 Nov; 113(9):1956-1967. PubMed ID: 29117520
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Calmodulin (CaM) Activates PI3Kα by Targeting the "Soft" CaM-Binding Motifs in Both the nSH2 and cSH2 Domains of p85α.
    Zhang M; Li Z; Wang G; Jang H; Sacks DB; Zhang J; Gaponenko V; Nussinov R
    J Phys Chem B; 2018 Dec; 122(49):11137-11146. PubMed ID: 30047727
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit.
    Wang G; Zhang M; Jang H; Lu S; Lin S; Chen G; Nussinov R; Zhang J; Gaponenko V
    Biochemistry; 2018 Mar; 57(12):1917-1928. PubMed ID: 29494137
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Insight into the mechanism of allosteric activation of PI3Kα by oncoprotein K-Ras4B.
    Li X; Dai J; Ni D; He X; Zhang H; Zhang J; Fu Q; Liu Y; Lu S
    Int J Biol Macromol; 2020 Feb; 144():643-655. PubMed ID: 31816384
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Calmodulin and IQGAP1 activation of PI3Kα and Akt in KRAS, HRAS and NRAS-driven cancers.
    Nussinov R; Zhang M; Tsai CJ; Jang H
    Biochim Biophys Acta Mol Basis Dis; 2018 Jun; 1864(6 Pt B):2304-2314. PubMed ID: 29097261
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Computational Insights into the Interactions between Calmodulin and the c/nSH2 Domains of p85α Regulatory Subunit of PI3Kα: Implication for PI3Kα Activation by Calmodulin.
    Ni D; Liu D; Zhang J; Lu S
    Int J Mol Sci; 2018 Jan; 19(1):. PubMed ID: 29300353
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.
    Jang H; Banerjee A; Chavan T; Gaponenko V; Nussinov R
    J Biol Chem; 2017 Jul; 292(30):12544-12559. PubMed ID: 28623230
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Calmodulin and PI3K Signaling in
    Nussinov R; Wang G; Tsai CJ; Jang H; Lu S; Banerjee A; Zhang J; Gaponenko V
    Trends Cancer; 2017 Mar; 3(3):214-224. PubMed ID: 28462395
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas.
    Nussinov R; Muratcioglu S; Tsai CJ; Jang H; Gursoy A; Keskin O
    Mol Cancer Res; 2015 Sep; 13(9):1265-73. PubMed ID: 26085527
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit.
    Shekar SC; Wu H; Fu Z; Yip SC; Nagajyothi ; Cahill SM; Girvin ME; Backer JM
    J Biol Chem; 2005 Jul; 280(30):27850-5. PubMed ID: 15932879
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits.
    Holt KH; Olson L; Moye-Rowley WS; Pessin JE
    Mol Cell Biol; 1994 Jan; 14(1):42-9. PubMed ID: 8264609
    [TBL] [Abstract][Full Text] [Related]  

  • 12. K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?
    Nussinov R; Muratcioglu S; Tsai CJ; Jang H; Gursoy A; Keskin O
    Expert Opin Ther Targets; 2016 Jul; 20(7):831-42. PubMed ID: 26873344
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The structural basis for Ras activation of PI3Kα lipid kinase.
    Zhang M; Jang H; Nussinov R
    Phys Chem Chem Phys; 2019 Jun; 21(22):12021-12028. PubMed ID: 31135801
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras.
    Jimenez C; Hernandez C; Pimentel B; Carrera AC
    J Biol Chem; 2002 Nov; 277(44):41556-62. PubMed ID: 12196526
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The structural basis of Akt PH domain interaction with calmodulin.
    Weako J; Jang H; Keskin O; Nussinov R; Gursoy A
    Biophys J; 2021 May; 120(10):1994-2008. PubMed ID: 33775637
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases.
    Zhang M; Jang H; Nussinov R
    J Mol Biol; 2020 Nov; 432(22):5849-5859. PubMed ID: 32918948
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Activation of PI3K/Akt signaling by n-terminal SH2 domain mutants of the p85α regulatory subunit of PI3K is enhanced by deletion of its c-terminal SH2 domain.
    Hofmann BT; Jücker M
    Cell Signal; 2012 Oct; 24(10):1950-4. PubMed ID: 22735814
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Allosteric Activation of PI3Kα Results in Dynamic Access to Catalytically Competent Conformations.
    Chakrabarti M; Gabelli SB; Amzel LM
    Structure; 2020 Apr; 28(4):465-474.e5. PubMed ID: 32049032
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains.
    Yu J; Wjasow C; Backer JM
    J Biol Chem; 1998 Nov; 273(46):30199-203. PubMed ID: 9804776
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural basis of nSH2 regulation and lipid binding in PI3Kα.
    Miller MS; Schmidt-Kittler O; Bolduc DM; Brower ET; Chaves-Moreira D; Allaire M; Kinzler KW; Jennings IG; Thompson PE; Cole PA; Amzel LM; Vogelstein B; Gabelli SB
    Oncotarget; 2014 Jul; 5(14):5198-208. PubMed ID: 25105564
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.