BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

475 related articles for article (PubMed ID: 29121928)

  • 1. A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein-protein interactions identifies a novel putative Mdm2-binding site in p53.
    Wong JH; Alfatah M; Sin MF; Sim HM; Verma CS; Lane DP; Arumugam P
    BMC Biol; 2017 Nov; 15(1):108. PubMed ID: 29121928
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The fluorescent two-hybrid assay to screen for protein-protein interaction inhibitors in live cells: targeting the interaction of p53 with Mdm2 and Mdm4.
    Yurlova L; Derks M; Buchfellner A; Hickson I; Janssen M; Morrison D; Stansfield I; Brown CJ; Ghadessy FJ; Lane DP; Rothbauer U; Zolghadr K; Krausz E
    J Biomol Screen; 2014 Apr; 19(4):516-25. PubMed ID: 24476585
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of a new small-molecule inhibitor of p53-MDM2 interaction using a yeast-based approach.
    Leão M; Pereira C; Bisio A; Ciribilli Y; Paiva AM; Machado N; Palmeira A; Fernandes MX; Sousa E; Pinto M; Inga A; Saraiva L
    Biochem Pharmacol; 2013 May; 85(9):1234-45. PubMed ID: 23428467
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53-MDM2 interaction.
    Li J; Zhang S; Gao L; Chen Y; Xie X
    J Biomol Screen; 2011 Apr; 16(4):450-6. PubMed ID: 21471462
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2.
    Dudgeon DD; Shinde SN; Shun TY; Lazo JS; Strock CJ; Giuliano KA; Taylor DL; Johnston PA; Johnston PA
    Assay Drug Dev Technol; 2010 Aug; 8(4):437-58. PubMed ID: 20662736
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Novel simplified yeast-based assays of regulators of p53-MDMX interaction and p53 transcriptional activity.
    Leão M; Gomes S; Soares J; Bessa C; Maciel C; Ciribilli Y; Pereira C; Inga A; Saraiva L
    FEBS J; 2013 Dec; 280(24):6498-507. PubMed ID: 24119020
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction.
    Soares J; Pereira NA; Monteiro Â; Leão M; Bessa C; Dos Santos DJ; Raimundo L; Queiroz G; Bisio A; Inga A; Pereira C; Santos MM; Saraiva L
    Eur J Pharm Sci; 2015 Jan; 66():138-47. PubMed ID: 25312347
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: identification of novel peptidic inhibitors.
    Noguchi T; Oishi S; Honda K; Kondoh Y; Saito T; Kubo T; Kaneda M; Ohno H; Osada H; Fujii N
    Bioorg Med Chem Lett; 2013 Jul; 23(13):3802-5. PubMed ID: 23726030
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Studying p53 family proteins in yeast: induction of autophagic cell death and modulation by interactors and small molecules.
    Leão M; Gomes S; Bessa C; Soares J; Raimundo L; Monti P; Fronza G; Pereira C; Saraiva L
    Exp Cell Res; 2015 Jan; 330(1):164-77. PubMed ID: 25265062
    [TBL] [Abstract][Full Text] [Related]  

  • 10. LC-MS/MS-based targeted proteomics quantitatively detects the interaction between p53 and MDM2 in breast cancer.
    Zhang W; Zhong T; Chen Y
    J Proteomics; 2017 Jan; 152():172-180. PubMed ID: 27826076
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits.
    Dudgeon DD; Shinde S; Hua Y; Shun TY; Lazo JS; Strock CJ; Giuliano KA; Taylor DL; Johnston PA; Johnston PA
    J Biomol Screen; 2010 Aug; 15(7):766-82. PubMed ID: 20639499
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A facile method to screen inhibitors of protein-protein interactions including MDM2-p53 displayed on T7 phage.
    Ishi K; Sugawara F
    Biochem Pharmacol; 2008 May; 75(9):1743-50. PubMed ID: 18384755
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Recent Small-Molecule Inhibitors of the p53-MDM2 Protein-Protein Interaction.
    Beloglazkina A; Zyk N; Majouga A; Beloglazkina E
    Molecules; 2020 Mar; 25(5):. PubMed ID: 32156064
    [TBL] [Abstract][Full Text] [Related]  

  • 14. An integrated in silico screening strategy for identifying promising disruptors of p53-MDM2 interaction.
    Sirous H; Chemi G; Campiani G; Brogi S
    Comput Biol Chem; 2019 Dec; 83():107105. PubMed ID: 31473433
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A genetic approach to mapping the p53 binding site in the MDM2 protein.
    Freedman DA; Epstein CB; Roth JC; Levine AJ
    Mol Med; 1997 Apr; 3(4):248-59. PubMed ID: 9131587
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of High Affinity Non-Peptidic Small Molecule Inhibitors of MDM2-p53 Interactions through Structure-Based Virtual Screening Strategies.
    Bandaru S; Ponnala D; Lakkaraju C; Bhukya CK; Shaheen U; Nayarisseri A
    Asian Pac J Cancer Prev; 2015; 16(9):3759-65. PubMed ID: 25987034
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Development of a novel immunoassay to detect interactions with the transactivation domain of p53: application to screening of new drugs.
    Xiong Y; Wu Y; Luo S; Gao Y; Xiong Y; Chen D; Deng H; Hao W; Liu T; Li M
    Sci Rep; 2017 Aug; 7(1):9185. PubMed ID: 28835687
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Ensemble-based virtual screening reveals dual-inhibitors for the p53-MDM2/MDMX interactions.
    Barakat K; Mane J; Friesen D; Tuszynski J
    J Mol Graph Model; 2010 Feb; 28(6):555-68. PubMed ID: 20056466
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Small molecule inhibitors of the p53-MDM2.
    Hu CQ; Hu YZ
    Curr Med Chem; 2008; 15(17):1720-30. PubMed ID: 18673221
    [TBL] [Abstract][Full Text] [Related]  

  • 20. DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties.
    Soares J; Espadinha M; Raimundo L; Ramos H; Gomes AS; Gomes S; Loureiro JB; Inga A; Reis F; Gomes C; Santos MMM; Saraiva L
    Mol Oncol; 2017 Jun; 11(6):612-627. PubMed ID: 28296148
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 24.