594 related articles for article (PubMed ID: 29123071)
1. SAMTOR is an
Gu X; Orozco JM; Saxton RA; Condon KJ; Liu GY; Krawczyk PA; Scaria SM; Harper JW; Gygi SP; Sabatini DM
Science; 2017 Nov; 358(6364):813-818. PubMed ID: 29123071
[TBL] [Abstract][Full Text] [Related]
2. Molecular mechanism of
Tang X; Zhang Y; Wang G; Zhang C; Wang F; Shi J; Zhang T; Ding J
Sci Adv; 2022 Jul; 8(26):eabn3868. PubMed ID: 35776786
[TBL] [Abstract][Full Text] [Related]
3. Betaine Delayed Muscle Loss by Attenuating Samtor Complex Inhibition for mTORC1 Signaling Via Increasing SAM Level.
Chen S; Lu XT; He TT; Yishake D; Tan XY; Hou MJ; Luo Y; Long JA; Tang ZH; Zhong RH; Fang AP; Zhu HL
Mol Nutr Food Res; 2021 Aug; 65(15):e2100157. PubMed ID: 34061446
[TBL] [Abstract][Full Text] [Related]
4. PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2.
Jiang C; Liu J; He S; Xu W; Huang R; Pan W; Li X; Dai X; Guo J; Zhang T; Inuzuka H; Wang P; Asara JM; Xiao J; Wei W
Cell Metab; 2023 Dec; 35(12):2183-2199.e7. PubMed ID: 38006878
[TBL] [Abstract][Full Text] [Related]
5. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Bar-Peled L; Chantranupong L; Cherniack AD; Chen WW; Ottina KA; Grabiner BC; Spear ED; Carter SL; Meyerson M; Sabatini DM
Science; 2013 May; 340(6136):1100-6. PubMed ID: 23723238
[TBL] [Abstract][Full Text] [Related]
6. Genetic Targeting of dSAMTOR, A Negative dTORC1 Regulator, during
Katarachia SA; Markaki SP; Velentzas AD; Stravopodis DJ
Int J Mol Sci; 2023 Jun; 24(11):. PubMed ID: 37298625
[TBL] [Abstract][Full Text] [Related]
7. mTORC1 stimulates cell growth through SAM synthesis and m
Villa E; Sahu U; O'Hara BP; Ali ES; Helmin KA; Asara JM; Gao P; Singer BD; Ben-Sahra I
Mol Cell; 2021 May; 81(10):2076-2093.e9. PubMed ID: 33756106
[TBL] [Abstract][Full Text] [Related]
8. Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction.
Pal R; Palmieri M; Chaudhury A; Klisch TJ; di Ronza A; Neilson JR; Rodney GG; Sardiello M
Nat Commun; 2018 Oct; 9(1):4351. PubMed ID: 30341294
[TBL] [Abstract][Full Text] [Related]
9. Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
Shen K; Huang RK; Brignole EJ; Condon KJ; Valenstein ML; Chantranupong L; Bomaliyamu A; Choe A; Hong C; Yu Z; Sabatini DM
Nature; 2018 Apr; 556(7699):64-69. PubMed ID: 29590090
[TBL] [Abstract][Full Text] [Related]
10. Redundant electrostatic interactions between GATOR1 and the Rag GTPase heterodimer drive efficient amino acid sensing in human cells.
Doxsey DD; Tettoni SD; Egri SB; Shen K
J Biol Chem; 2023 Jul; 299(7):104880. PubMed ID: 37269949
[TBL] [Abstract][Full Text] [Related]
11. Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Egri SB; Ouch C; Chou HT; Yu Z; Song K; Xu C; Shen K
Mol Cell; 2022 May; 82(10):1836-1849.e5. PubMed ID: 35338845
[TBL] [Abstract][Full Text] [Related]
12. Methionine Protects Mammary Cells against Oxidative Stress through Producing S-Adenosylmethionine to Maintain mTORC1 Signaling Activity.
Zhong H; Yuan P; Li Y; Batonon-Alavo D; Deschamps C; Feng B; Zhang X; Che L; Lin Y; Xu S; Li J; Zhuo Y; Tian G; Tang J; Jiang X; Huang L; Wu C; Wu D; Fang Z
Oxid Med Cell Longev; 2021; 2021():5550196. PubMed ID: 34336098
[TBL] [Abstract][Full Text] [Related]
13. The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.
Chantranupong L; Wolfson RL; Orozco JM; Saxton RA; Scaria SM; Bar-Peled L; Spooner E; Isasa M; Gygi SP; Sabatini DM
Cell Rep; 2014 Oct; 9(1):1-8. PubMed ID: 25263562
[TBL] [Abstract][Full Text] [Related]
14. Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.
Shen K; Valenstein ML; Gu X; Sabatini DM
J Biol Chem; 2019 Feb; 294(8):2970-2975. PubMed ID: 30651352
[TBL] [Abstract][Full Text] [Related]
15. Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
de Araujo MEG; Naschberger A; Fürnrohr BG; Stasyk T; Dunzendorfer-Matt T; Lechner S; Welti S; Kremser L; Shivalingaiah G; Offterdinger M; Lindner HH; Huber LA; Scheffzek K
Science; 2017 Oct; 358(6361):377-381. PubMed ID: 28935770
[TBL] [Abstract][Full Text] [Related]
16. An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway.
Liu GY; Jouandin P; Bahng RE; Perrimon N; Sabatini DM
Nat Commun; 2024 Mar; 15(1):2517. PubMed ID: 38514639
[TBL] [Abstract][Full Text] [Related]
17. Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
Shin HR; Citron YR; Wang L; Tribouillard L; Goul CS; Stipp R; Sugasawa Y; Jain A; Samson N; Lim CY; Davis OB; Castaneda-Carpio D; Qian M; Nomura DK; Perera RM; Park E; Covey DF; Laplante M; Evers AS; Zoncu R
Science; 2022 Sep; 377(6612):1290-1298. PubMed ID: 36007018
[TBL] [Abstract][Full Text] [Related]
18. SNAT7 regulates mTORC1 via macropinocytosis.
Meng D; Yang Q; Jeong MH; Curukovic A; Tiwary S; Melick CH; Lama-Sherpa TD; Wang H; Huerta-Rosario M; Urquhart G; Zacharias LG; Lewis C; DeBerardinis RJ; Jewell JL
Proc Natl Acad Sci U S A; 2022 May; 119(20):e2123261119. PubMed ID: 35561222
[TBL] [Abstract][Full Text] [Related]
19. Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.
Shen K; Sabatini DM
Proc Natl Acad Sci U S A; 2018 Sep; 115(38):9545-9550. PubMed ID: 30181260
[TBL] [Abstract][Full Text] [Related]
20. Sensors for the mTORC1 pathway regulated by amino acids.
Li XZ; Yan XH
J Zhejiang Univ Sci B; 2019 Sept.; 20(9):699-712. PubMed ID: 31379141
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]