These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

275 related articles for article (PubMed ID: 29123114)

  • 1. Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.
    Zhang T; Wang R; Wang Z; Wang X; Wang F; Ding J
    Nat Commun; 2017 Nov; 8(1):1394. PubMed ID: 29123114
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural basis for the assembly of the Ragulator-Rag GTPase complex.
    Yonehara R; Nada S; Nakai T; Nakai M; Kitamura A; Ogawa A; Nakatsumi H; Nakayama KI; Li S; Standley DM; Yamashita E; Nakagawa A; Okada M
    Nat Commun; 2017 Nov; 8(1):1625. PubMed ID: 29158492
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.
    Shen K; Sabatini DM
    Proc Natl Acad Sci U S A; 2018 Sep; 115(38):9545-9550. PubMed ID: 30181260
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1.
    Nada S; Okada M
    J Biochem; 2020 Dec; 168(6):621-632. PubMed ID: 32653916
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.
    Schweitzer LD; Comb WC; Bar-Peled L; Sabatini DM
    Cell Rep; 2015 Sep; 12(9):1445-55. PubMed ID: 26299971
    [TBL] [Abstract][Full Text] [Related]  

  • 6. C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly.
    Rasheed N; Lima TB; Mercaldi GF; Nascimento AFZ; Silva ALS; Righetto GL; Bar-Peled L; Shen K; Sabatini DM; Gozzo FC; Aparicio R; Smetana JHC
    FEBS Open Bio; 2019 Sep; 9(9):1589-1602. PubMed ID: 31314152
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Rag-Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway.
    Valenstein ML; Lalgudi PV; Gu X; Kedir JF; Taylor MS; Chivukula RR; Sabatini DM
    Proc Natl Acad Sci U S A; 2024 Aug; 121(35):e2322755121. PubMed ID: 39163330
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
    Bar-Peled L; Schweitzer LD; Zoncu R; Sabatini DM
    Cell; 2012 Sep; 150(6):1196-208. PubMed ID: 22980980
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
    Sancak Y; Bar-Peled L; Zoncu R; Markhard AL; Nada S; Sabatini DM
    Cell; 2010 Apr; 141(2):290-303. PubMed ID: 20381137
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
    Su MY; Morris KL; Kim DJ; Fu Y; Lawrence R; Stjepanovic G; Zoncu R; Hurley JH
    Mol Cell; 2017 Dec; 68(5):835-846.e3. PubMed ID: 29107538
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold.
    Lawrence RE; Cho KF; Rappold R; Thrun A; Tofaute M; Kim DJ; Moldavski O; Hurley JH; Zoncu R
    Nat Cell Biol; 2018 Sep; 20(9):1052-1063. PubMed ID: 30061680
    [TBL] [Abstract][Full Text] [Related]  

  • 12. p18/LAMTOR1: a late endosome/lysosome-specific anchor protein for the mTORC1/MAPK signaling pathway.
    Nada S; Mori S; Takahashi Y; Okada M
    Methods Enzymol; 2014; 535():249-63. PubMed ID: 24377928
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
    Egri SB; Ouch C; Chou HT; Yu Z; Song K; Xu C; Shen K
    Mol Cell; 2022 May; 82(10):1836-1849.e5. PubMed ID: 35338845
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.
    Ögmundsdóttir MH; Heublein S; Kazi S; Reynolds B; Visvalingam SM; Shaw MK; Goberdhan DC
    PLoS One; 2012; 7(5):e36616. PubMed ID: 22574197
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.
    Jung J; Genau HM; Behrends C
    Mol Cell Biol; 2015 Jul; 35(14):2479-94. PubMed ID: 25963655
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Glutamine and asparagine activate mTORC1 independently of Rag GTPases.
    Meng D; Yang Q; Wang H; Melick CH; Navlani R; Frank AR; Jewell JL
    J Biol Chem; 2020 Mar; 295(10):2890-2899. PubMed ID: 32019866
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
    Cui Z; Napolitano G; de Araujo MEG; Esposito A; Monfregola J; Huber LA; Ballabio A; Hurley JH
    Nature; 2023 Feb; 614(7948):572-579. PubMed ID: 36697823
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Regulation of mTORC1 by the Rag GTPases.
    Lama-Sherpa TD; Jeong MH; Jewell JL
    Biochem Soc Trans; 2023 Apr; 51(2):655-664. PubMed ID: 36929165
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
    de Araujo MEG; Naschberger A; Fürnrohr BG; Stasyk T; Dunzendorfer-Matt T; Lechner S; Welti S; Kremser L; Shivalingaiah G; Offterdinger M; Lindner HH; Huber LA; Scheffzek K
    Science; 2017 Oct; 358(6361):377-381. PubMed ID: 28935770
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Rag GTPase in amino acid signaling.
    Kim J; Kim E
    Amino Acids; 2016 Apr; 48(4):915-928. PubMed ID: 26781224
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.