251 related articles for article (PubMed ID: 29127710)
1. Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi.
Vázquez C; Mejia-Tlachi M; González-Chávez Z; Silva A; Rodríguez-Zavala JS; Moreno-Sánchez R; Saavedra E
FEBS Lett; 2017 Dec; 591(23):3881-3894. PubMed ID: 29127710
[TBL] [Abstract][Full Text] [Related]
2. Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity.
González-Chávez Z; Vázquez C; Mejia-Tlachi M; Márquez-Dueñas C; Manning-Cela R; Encalada R; Rodríguez-Enríquez S; Michels PAM; Moreno-Sánchez R; Saavedra E
Redox Biol; 2019 Sep; 26():101231. PubMed ID: 31203195
[TBL] [Abstract][Full Text] [Related]
3. Drug target validation of the trypanothione pathway enzymes through metabolic modelling.
Olin-Sandoval V; González-Chávez Z; Berzunza-Cruz M; Martínez I; Jasso-Chávez R; Becker I; Espinoza B; Moreno-Sánchez R; Saavedra E
FEBS J; 2012 May; 279(10):1811-33. PubMed ID: 22394478
[TBL] [Abstract][Full Text] [Related]
4. Gene knockdown of gamma-glutamylcysteine synthetase by RNAi in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzyme.
Huynh TT; Huynh VT; Harmon MA; Phillips MA
J Biol Chem; 2003 Oct; 278(41):39794-800. PubMed ID: 12888552
[TBL] [Abstract][Full Text] [Related]
5. Trypanothione biosynthesis in Leishmania major.
Oza SL; Shaw MP; Wyllie S; Fairlamb AH
Mol Biochem Parasitol; 2005 Jan; 139(1):107-16. PubMed ID: 15610825
[TBL] [Abstract][Full Text] [Related]
6. Properties of trypanothione synthetase from Trypanosoma brucei.
Oza SL; Ariyanayagam MR; Aitcheson N; Fairlamb AH
Mol Biochem Parasitol; 2003 Sep; 131(1):25-33. PubMed ID: 12967709
[TBL] [Abstract][Full Text] [Related]
7. Validation of Trypanosoma brucei trypanothione synthetase as drug target.
Comini MA; Guerrero SA; Haile S; Menge U; Lünsdorf H; Flohé L
Free Radic Biol Med; 2004 May; 36(10):1289-302. PubMed ID: 15110394
[TBL] [Abstract][Full Text] [Related]
8. Glutathione and trypanothione in several strains of Trypanosoma cruzi: effect of drugs.
Repetto Y; Opazo E; Maya JD; Agosin M; Morello A
Comp Biochem Physiol B Biochem Mol Biol; 1996 Oct; 115(2):281-5. PubMed ID: 8939007
[TBL] [Abstract][Full Text] [Related]
9. A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
Oza SL; Tetaud E; Ariyanayagam MR; Warnon SS; Fairlamb AH
J Biol Chem; 2002 Sep; 277(39):35853-61. PubMed ID: 12121990
[TBL] [Abstract][Full Text] [Related]
10. Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi.
Maya JD; Rodríguez A; Pino L; Pabón A; Ferreira J; Pavani M; Repetto Y; Morello A
Biol Res; 2004; 37(1):61-9. PubMed ID: 15174306
[TBL] [Abstract][Full Text] [Related]
11. Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods.
Wyllie S; Oza SL; Patterson S; Spinks D; Thompson S; Fairlamb AH
Mol Microbiol; 2009 Nov; 74(3):529-40. PubMed ID: 19558432
[TBL] [Abstract][Full Text] [Related]
12. Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum.
Sousa AF; Gomes-Alves AG; Benítez D; Comini MA; Flohé L; Jaeger T; Passos J; Stuhlmann F; Tomás AM; Castro H
Free Radic Biol Med; 2014 Aug; 73():229-38. PubMed ID: 24853758
[TBL] [Abstract][Full Text] [Related]
13. Trypanothione synthesis in crithidia revisited.
Comini M; Menge U; Wissing J; Flohé L
J Biol Chem; 2005 Feb; 280(8):6850-60. PubMed ID: 15537651
[TBL] [Abstract][Full Text] [Related]
14. Glutathione: an overview of biosynthesis and modulation.
Anderson ME
Chem Biol Interact; 1998 Apr; 111-112():1-14. PubMed ID: 9679538
[TBL] [Abstract][Full Text] [Related]
15. Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi.
Mesías AC; Sasoni N; Arias DG; Pérez Brandán C; Orban OCF; Kunick C; Robello C; Comini MA; Garg NJ; Zago MP
Free Radic Biol Med; 2019 Jan; 130():23-34. PubMed ID: 30359758
[TBL] [Abstract][Full Text] [Related]
16. Glutathione homeostasis in human hepatic cells: overexpression of gamma-glutamylcysteine synthetase gene in cell lines resistant to buthionine sulfoximine, an inhibitor of glutathione synthesis.
Tanaka T; Uchiumi T; Kohno K; Tomonari A; Nishio K; Saijo N; Kondo T; Kuwano M
Biochem Biophys Res Commun; 1998 May; 246(2):398-403. PubMed ID: 9610371
[TBL] [Abstract][Full Text] [Related]
17. Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome.
Ariyanayagam MR; Oza SL; Guther ML; Fairlamb AH
Biochem J; 2005 Oct; 391(Pt 2):425-32. PubMed ID: 16008527
[TBL] [Abstract][Full Text] [Related]
18. Characterization of Trypanosoma brucei gamma-glutamylcysteine synthetase, an essential enzyme in the biosynthesis of trypanothione (diglutathionylspermidine).
Lueder DV; Phillips MA
J Biol Chem; 1996 Jul; 271(29):17485-90. PubMed ID: 8663359
[TBL] [Abstract][Full Text] [Related]
19. Buthionine sulfoximine diverts the melanogenesis pathway toward the production of more soluble and degradable pigments.
Galván I; Wakamatsu K; Alonso-Alvarez C; Solano F
Bioorg Med Chem Lett; 2014 May; 24(9):2150-4. PubMed ID: 24703231
[TBL] [Abstract][Full Text] [Related]
20. Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
Ariyanayagam MR; Oza SL; Mehlert A; Fairlamb AH
J Biol Chem; 2003 Jul; 278(30):27612-9. PubMed ID: 12750367
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]