309 related articles for article (PubMed ID: 29150432)
1. The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists.
Bodur C; Kazyken D; Huang K; Ekim Ustunel B; Siroky KA; Tooley AS; Gonzalez IE; Foley DH; Acosta-Jaquez HA; Barnes TM; Steinl GK; Cho KW; Lumeng CN; Riddle SM; Myers MG; Fingar DC
EMBO J; 2018 Jan; 37(1):19-38. PubMed ID: 29150432
[TBL] [Abstract][Full Text] [Related]
2. The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt.
Tooley AS; Kazyken D; Bodur C; Gonzalez IE; Fingar DC
J Biol Chem; 2021 Aug; 297(2):100942. PubMed ID: 34245780
[TBL] [Abstract][Full Text] [Related]
3. TBK1-mTOR Signaling Attenuates Obesity-Linked Hyperglycemia and Insulin Resistance.
Bodur C; Kazyken D; Huang K; Tooley AS; Cho KW; Barnes TM; Lumeng CN; Myers MG; Fingar DC
Diabetes; 2022 Nov; 71(11):2297-2312. PubMed ID: 35983955
[TBL] [Abstract][Full Text] [Related]
4. Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism.
Hasan M; Gonugunta VK; Dobbs N; Ali A; Palchik G; Calvaruso MA; DeBerardinis RJ; Yan N
Proc Natl Acad Sci U S A; 2017 Jan; 114(4):746-751. PubMed ID: 28069950
[TBL] [Abstract][Full Text] [Related]
5. TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877.
Antonia RJ; Castillo J; Herring LE; Serafin DS; Liu P; Graves LM; Baldwin AS; Hagan RS
Sci Rep; 2019 Sep; 9(1):13470. PubMed ID: 31530866
[TBL] [Abstract][Full Text] [Related]
6. Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.
Bakshi S; Taylor J; Strickson S; McCartney T; Cohen P
Biochem J; 2017 Mar; 474(7):1163-1174. PubMed ID: 28159912
[TBL] [Abstract][Full Text] [Related]
7. Mechanism of endogenous regulation of the type I interferon response by suppressor of IκB kinase epsilon (SIKE), a novel substrate of TANK-binding kinase 1 (TBK1).
Marion JD; Roberts CF; Call RJ; Forbes JL; Nelson KT; Bell JE; Bell JK
J Biol Chem; 2013 Jun; 288(25):18612-23. PubMed ID: 23649622
[TBL] [Abstract][Full Text] [Related]
8. DOK3 is required for IFN-β production by enabling TRAF3/TBK1 complex formation and IRF3 activation.
Kim SS; Lee KG; Chin CS; Ng SK; Pereira NA; Xu S; Lam KP
J Immunol; 2014 Jul; 193(2):840-8. PubMed ID: 24929003
[TBL] [Abstract][Full Text] [Related]
9. Role of Herpes Simplex Virus 1 γ34.5 in the Regulation of IRF3 Signaling.
Manivanh R; Mehrbach J; Knipe DM; Leib DA
J Virol; 2017 Dec; 91(23):. PubMed ID: 28904192
[TBL] [Abstract][Full Text] [Related]
10. SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity.
Liu D; Sheng C; Gao S; Yao C; Li J; Jiang W; Chen H; Wu J; Pan C; Chen S; Huang W
Mol Cell Biol; 2015 Jul; 35(14):2400-13. PubMed ID: 25939384
[TBL] [Abstract][Full Text] [Related]
11. Adenovirus induction of IRF3 occurs through a binary trigger targeting Jun N-terminal kinase and TBK1 kinase cascades and type I interferon autocrine signaling.
Nociari M; Ocheretina O; Murphy M; Falck-Pedersen E
J Virol; 2009 May; 83(9):4081-91. PubMed ID: 19211767
[TBL] [Abstract][Full Text] [Related]
12. Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity.
Moriyama M; Igarashi M; Koshiba T; Irie T; Takada A; Ichinohe T
J Virol; 2018 Oct; 92(19):. PubMed ID: 30021900
[TBL] [Abstract][Full Text] [Related]
13. TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation.
Hu YW; Zhang J; Wu XM; Cao L; Nie P; Chang MX
Front Immunol; 2018; 9():84. PubMed ID: 29441066
[TBL] [Abstract][Full Text] [Related]
14. mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression.
Ekim B; Magnuson B; Acosta-Jaquez HA; Keller JA; Feener EP; Fingar DC
Mol Cell Biol; 2011 Jul; 31(14):2787-801. PubMed ID: 21576368
[TBL] [Abstract][Full Text] [Related]
15. Regulation of RLR-Mediated Antiviral Responses of Human Dendritic Cells by mTOR.
Fekete T; Ágics B; Bencze D; Bene K; Szántó A; Tarr T; Veréb Z; Bácsi A; Pázmándi K
Front Immunol; 2020; 11():572960. PubMed ID: 33013932
[TBL] [Abstract][Full Text] [Related]
16. Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis.
Hammaker D; Boyle DL; Firestein GS
Rheumatology (Oxford); 2012 Apr; 51(4):610-8. PubMed ID: 21613249
[TBL] [Abstract][Full Text] [Related]
17. The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling.
Zhang H; Han C; Li T; Li N; Cao X
Cell Mol Immunol; 2019 Oct; 16(10):800-809. PubMed ID: 29973649
[TBL] [Abstract][Full Text] [Related]
18. Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7.
Unterholzner L; Sumner RP; Baran M; Ren H; Mansur DS; Bourke NM; Randow F; Smith GL; Bowie AG
PLoS Pathog; 2011 Sep; 7(9):e1002247. PubMed ID: 21931555
[TBL] [Abstract][Full Text] [Related]
19. STK4 Deficiency Impairs Innate Immunity and Interferon Production Through Negative Regulation of TBK1-IRF3 Signaling.
Jørgensen SE; Al-Mousawi A; Assing K; Hartling U; Grosen D; Fisker N; Nielsen C; Jakobsen MA; Mogensen TH
J Clin Immunol; 2021 Jan; 41(1):109-124. PubMed ID: 33078349
[TBL] [Abstract][Full Text] [Related]
20. TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis.
Zhu L; Li Y; Xie X; Zhou X; Gu M; Jie Z; Ko CJ; Gao T; Hernandez BE; Cheng X; Sun SC
Nat Cell Biol; 2019 Dec; 21(12):1604-1614. PubMed ID: 31792381
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]