BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 29159133)

  • 1. Integration of novel approaches demonstrates simultaneous metabolic inactivation and CAR-mediated hepatocarcinogenesis of a nitrification inhibitor.
    LaRocca JL; Rasoulpour RJ; Gollapudi BB; Eisenbrandt DL; Murphy LA; LeBaron MJ
    Toxicol Rep; 2017; 4():586-597. PubMed ID: 29159133
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Bridging Sex-Specific Differences in the CAR-Mediated Hepatocarcinogenesis of Nitrapyrin Using Molecular and Apical Endpoints.
    Murphy L; LeBaron MJ; Johnson K; Rasoulpour RJ; Wang X; LaRocca J
    Front Toxicol; 2021; 3():766196. PubMed ID: 35295143
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Characterization of nuclear receptor-mediated murine hepatocarcinogenesis of the herbicide pronamide and its human relevance.
    LeBaron MJ; Rasoulpour RJ; Gollapudi BB; Sura R; Kan HL; Schisler MR; Pottenger LH; Papineni S; Eisenbrandt DL
    Toxicol Sci; 2014 Nov; 142(1):74-92. PubMed ID: 25092647
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance.
    Lake BG; Price RJ; Scott MP; Chatham LR; Vardy A; Osimitz TG
    Toxicology; 2020 Jun; 439():152465. PubMed ID: 32320717
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator.
    Elcombe CR; Peffer RC; Wolf DC; Bailey J; Bars R; Bell D; Cattley RC; Ferguson SS; Geter D; Goetz A; Goodman JI; Hester S; Jacobs A; Omiecinski CJ; Schoeny R; Xie W; Lake BG
    Crit Rev Toxicol; 2014 Jan; 44(1):64-82. PubMed ID: 24180433
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR).
    Yamada T; Cohen SM; Lake BG
    Crit Rev Toxicol; 2021 May; 51(5):373-394. PubMed ID: 34264181
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Minimum datasets to establish a CAR-mediated mode of action for rodent liver tumors.
    Peffer RC; LeBaron MJ; Battalora M; Bomann WH; Werner C; Aggarwal M; Rowe RR; Tinwell H
    Regul Toxicol Pharmacol; 2018 Jul; 96():106-120. PubMed ID: 29673940
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Methyl isobutyl ketone-induced hepatocellular carcinogenesis in B6C3F
    Hughes BJ; Thomas J; Lynch AM; Borghoff SJ; Green S; Mensing T; Sarang SS; LeBaron MJ
    Regul Toxicol Pharmacol; 2016 Nov; 81():421-429. PubMed ID: 27664318
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Toxaphene-induced mouse liver tumorigenesis is mediated by the constitutive androstane receptor.
    Wang Z; Li X; Wu Q; Lamb JC; Klaunig JE
    J Appl Toxicol; 2017 Aug; 37(8):967-975. PubMed ID: 28218408
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Constitutive androstane receptor (CAR) mediates dieldrin-induced liver tumorigenesis in mouse.
    Wang Z; Wu Q; Li X; Klaunig JE
    Arch Toxicol; 2020 Aug; 94(8):2873-2884. PubMed ID: 32435917
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Human relevance framework for rodent liver tumors induced by the insecticide sulfoxaflor.
    LeBaron MJ; Gollapudi BB; Terry C; Billington R; Rasoulpour RJ
    Crit Rev Toxicol; 2014 May; 44 Suppl 2():15-24. PubMed ID: 24832551
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Editor's Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes.
    Okuda Y; Kushida M; Sumida K; Nagahori H; Nakamura Y; Higuchi H; Kawamura S; Lake BG; Cohen SM; Yamada T
    Toxicol Sci; 2017 Aug; 158(2):412-430. PubMed ID: 28520973
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Thyroid tumor formation in the male mouse induced by fluopyram is mediated by activation of hepatic CAR/PXR nuclear receptors.
    Rouquié D; Tinwell H; Blanck O; Schorsch F; Geter D; Wason S; Bars R
    Regul Toxicol Pharmacol; 2014 Dec; 70(3):673-80. PubMed ID: 25455223
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Essential role of constitutive androstane receptor in Ginkgo biloba extract induced liver hypertrophy and hepatocarcinogenesis.
    Maeda J; Inoue K; Ichimura R; Takahashi M; Kodama Y; Saito N; Yoshida M
    Food Chem Toxicol; 2015 Sep; 83():201-9. PubMed ID: 26115596
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mode of action and human relevance of THF-induced mouse liver tumors.
    Choi CJ; Rushton EK; Vardy A; Higgins L; Augello A; Parod RJ
    Toxicol Lett; 2017 Jul; 276():138-143. PubMed ID: 28495613
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.
    Luisier R; Lempiäinen H; Scherbichler N; Braeuning A; Geissler M; Dubost V; Müller A; Scheer N; Chibout SD; Hara H; Picard F; Theil D; Couttet P; Vitobello A; Grenet O; Grasl-Kraupp B; Ellinger-Ziegelbauer H; Thomson JP; Meehan RR; Elcombe CR; Henderson CJ; Wolf CR; Schwarz M; Moulin P; Terranova R; Moggs JG
    Toxicol Sci; 2014 Jun; 139(2):501-11. PubMed ID: 24690595
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dose-response modeling of early molecular and cellular key events in the CAR-mediated hepatocarcinogenesis pathway.
    Geter DR; Bhat VS; Gollapudi BB; Sura R; Hester SD
    Toxicol Sci; 2014 Apr; 138(2):425-45. PubMed ID: 24449422
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin.
    Okuda Y; Kushida M; Kikumoto H; Nakamura Y; Higuchi H; Kawamura S; Cohen SM; Lake BG; Yamada T
    J Toxicol Sci; 2017; 42(6):773-788. PubMed ID: 29142176
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Nitrapyrin: a scientific advisory group review of the mode of action and carcinogenicity in B6C3F1 mice.
    Yano BL; Hardisty JF; Seely JC; Butterworth BE; McConnell EE; Swenberg JA; Williams GM; Stebbins KE; Golllapudi BB; Eisenbrandt DL
    Regul Toxicol Pharmacol; 2008 Jun; 51(1):53-65. PubMed ID: 18367300
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mode of action analysis for pesticide-induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk.
    Lake BG; Price RJ; Osimitz TG
    Pest Manag Sci; 2015 Jun; 71(6):829-34. PubMed ID: 25045103
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.