BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

193 related articles for article (PubMed ID: 29184081)

  • 21. Structure-Based Drug Design of Novel Triaminotriazine Derivatives as Orally Bioavailable IDH2
    Wei Q; Yao K; Yang J; Zhou Q; Liu P; Chen J; Liu H; Lai Y; Cao P
    J Med Chem; 2023 Sep; 66(18):12894-12910. PubMed ID: 37706660
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2.
    Thirumal Kumar D; Jerushah Emerald L; George Priya Doss C; Sneha P; Siva R; Charles Emmanuel Jebaraj W; Zayed H
    Metab Brain Dis; 2018 Oct; 33(5):1699-1710. PubMed ID: 29987523
    [TBL] [Abstract][Full Text] [Related]  

  • 23. New IDH1 mutant inhibitors for treatment of acute myeloid leukemia.
    Okoye-Okafor UC; Bartholdy B; Cartier J; Gao EN; Pietrak B; Rendina AR; Rominger C; Quinn C; Smallwood A; Wiggall KJ; Reif AJ; Schmidt SJ; Qi H; Zhao H; Joberty G; Faelth-Savitski M; Bantscheff M; Drewes G; Duraiswami C; Brady P; Groy A; Narayanagari SR; Antony-Debre I; Mitchell K; Wang HR; Kao YR; Christopeit M; Carvajal L; Barreyro L; Paietta E; Makishima H; Will B; Concha N; Adams ND; Schwartz B; McCabe MT; Maciejewski J; Verma A; Steidl U
    Nat Chem Biol; 2015 Nov; 11(11):878-86. PubMed ID: 26436839
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Subunit interactions of yeast NAD+-specific isocitrate dehydrogenase.
    Panisko EA; McAlister-Henn L
    J Biol Chem; 2001 Jan; 276(2):1204-10. PubMed ID: 11042198
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Discovery and structure-activity-relationship study of novel conformationally restricted indane analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors.
    Zheng Q; Tang S; Fu X; Chen Z; Ye Y; Lan X; Jiang L; Huang Y; Ding J; Geng M; Huang M; Wan H
    Bioorg Med Chem Lett; 2017 Dec; 27(23):5262-5266. PubMed ID: 29079473
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Basis for half-site ligand binding in yeast NAD(+)-specific isocitrate dehydrogenase.
    Lin AP; McAlister-Henn L
    Biochemistry; 2011 Sep; 50(38):8241-50. PubMed ID: 21861471
    [TBL] [Abstract][Full Text] [Related]  

  • 27. IDH2 and NPM1 Mutations Cooperate to Activate Hoxa9/Meis1 and Hypoxia Pathways in Acute Myeloid Leukemia.
    Ogawara Y; Katsumoto T; Aikawa Y; Shima Y; Kagiyama Y; Soga T; Matsunaga H; Seki T; Araki K; Kitabayashi I
    Cancer Res; 2015 May; 75(10):2005-16. PubMed ID: 25795706
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity.
    Chambers JM; Miller W; Quichocho G; Upadhye V; Matteo DA; Bobkov AA; Sohl CD; Schiffer JM
    Biochemistry; 2020 Feb; 59(4):479-490. PubMed ID: 31869219
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Ligand binding and structural changes associated with allostery in yeast NAD(+)-specific isocitrate dehydrogenase.
    McAlister-Henn L
    Arch Biochem Biophys; 2012 Mar; 519(2):112-7. PubMed ID: 22008468
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Kinetic and physiological effects of alterations in homologous isocitrate-binding sites of yeast NAD(+)-specific isocitrate dehydrogenase.
    Lin AP; McCammon MT; McAlister-Henn L
    Biochemistry; 2001 Nov; 40(47):14291-301. PubMed ID: 11714283
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Homologous binding sites in yeast isocitrate dehydrogenase for cofactor (NAD+) and allosteric activator (AMP).
    Lin AP; McAlister-Henn L
    J Biol Chem; 2003 Apr; 278(15):12864-72. PubMed ID: 12562755
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Development of Novel Therapeutics Targeting Isocitrate Dehydrogenase Mutations in Cancer.
    Sharma H
    Curr Top Med Chem; 2018; 18(6):505-524. PubMed ID: 29773061
    [TBL] [Abstract][Full Text] [Related]  

  • 33. D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.
    Akbay EA; Moslehi J; Christensen CL; Saha S; Tchaicha JH; Ramkissoon SH; Stewart KM; Carretero J; Kikuchi E; Zhang H; Cohoon TJ; Murray S; Liu W; Uno K; Fisch S; Jones K; Gurumurthy S; Gliser C; Choe S; Keenan M; Son J; Stanley I; Losman JA; Padera R; Bronson RT; Asara JM; Abdel-Wahab O; Amrein PC; Fathi AT; Danial NN; Kimmelman AC; Kung AL; Ligon KL; Yen KE; Kaelin WG; Bardeesy N; Wong KK
    Genes Dev; 2014 Mar; 28(5):479-90. PubMed ID: 24589777
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction.
    Peng Y; Zhong C; Huang W; Ding J
    Protein Sci; 2008 Sep; 17(9):1542-54. PubMed ID: 18552125
    [TBL] [Abstract][Full Text] [Related]  

  • 35. [Effects of IDH2 Gene Mutation on Clinical Characteristics and Prognostic of Patients with Acute Myeloid Leukemia].
    Luo LQ; Peng ZY; Liu X; Yu WZ
    Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2019 Aug; 27(4):1077-1082. PubMed ID: 31418360
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Uncoupling of an ammonia channel as a mechanism of allosteric inhibition in anthranilate synthase of Serratia marcescens: dynamic and graph theoretical analysis.
    Srivastava A; Sinha S
    Mol Biosyst; 2016 Dec; 13(1):142-155. PubMed ID: 27833951
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Absence of R140Q mutation of isocitrate dehydrogenase 2 in gliomas and breast cancers.
    Raynaud S; Carbuccia N; Colin C; Adélaïde J; Mozziconacci MJ; Metellus P; Chinot O; Birnbaum D; Chaffanet M; Figarella-Branger D
    Oncol Lett; 2010 Sep; 1(5):883-884. PubMed ID: 22966399
    [TBL] [Abstract][Full Text] [Related]  

  • 38. IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition.
    Kernytsky A; Wang F; Hansen E; Schalm S; Straley K; Gliser C; Yang H; Travins J; Murray S; Dorsch M; Agresta S; Schenkein DP; Biller SA; Su SM; Liu W; Yen KE
    Blood; 2015 Jan; 125(2):296-303. PubMed ID: 25398940
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Rapid detection of IDH2 (R140Q and R172K) mutations in acute myeloid leukemia.
    Ashraf S; Noguera NI; Di Giandomenico J; Zaza S; Hasan SK; Lo-Coco F
    Ann Hematol; 2013 Oct; 92(10):1319-23. PubMed ID: 23949315
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Novel allosteric properties produced by residue substitutions in the subunit interface of yeast NAD+-specific isocitrate dehydrogenase.
    Hu G; McAlister-Henn L
    Arch Biochem Biophys; 2006 Sep; 453(2):207-16. PubMed ID: 16884682
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 10.