BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

330 related articles for article (PubMed ID: 29196786)

  • 1. Increased heterologous production of the antitumoral polyketide mithramycin A by engineered Streptomyces lividans TK24 strains.
    Novakova R; Núñez LE; Homerova D; Knirschova R; Feckova L; Rezuchova B; Sevcikova B; Menéndez N; Morís F; Cortés J; Kormanec J
    Appl Microbiol Biotechnol; 2018 Jan; 102(2):857-869. PubMed ID: 29196786
    [TBL] [Abstract][Full Text] [Related]  

  • 2. An efficient blue-white screening system for markerless deletions and stable integrations in Streptomyces chromosomes based on the blue pigment indigoidine biosynthetic gene bpsA.
    Rezuchova B; Homerova D; Sevcikova B; Núñez LE; Novakova R; Feckova L; Skultety L; Cortés J; Kormanec J
    Appl Microbiol Biotechnol; 2018 Dec; 102(23):10231-10244. PubMed ID: 30259098
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Engineering of Streptomyces lividans for heterologous expression of secondary metabolite gene clusters.
    Ahmed Y; Rebets Y; Estévez MR; Zapp J; Myronovskyi M; Luzhetskyy A
    Microb Cell Fact; 2020 Jan; 19(1):5. PubMed ID: 31918711
    [TBL] [Abstract][Full Text] [Related]  

  • 4. An efficient system for stable markerless integration of large biosynthetic gene clusters into Streptomyces chromosomes.
    Csolleiova D; Knirschova R; Rezuchova B; Homerova D; Sevcikova B; Matulova M; Núñez LE; Novakova R; Feckova L; Javorova R; Cortés J; Kormanec J
    Appl Microbiol Biotechnol; 2021 Mar; 105(5):2123-2137. PubMed ID: 33564923
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery, characterization, and engineering of an advantageous Streptomyces host for heterologous expression of natural product biosynthetic gene clusters.
    Klumbys E; Xu W; Koduru L; Heng E; Wei Y; Wong FT; Zhao H; Ang EL
    Microb Cell Fact; 2024 May; 23(1):149. PubMed ID: 38790014
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effects of Increased NADPH Concentration by Metabolic Engineering of the Pentose Phosphate Pathway on Antibiotic Production and Sporulation in
    Jin XM; Chang YK; Lee JH; Hong SK
    J Microbiol Biotechnol; 2017 Oct; 27(10):1867-1876. PubMed ID: 28838222
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Expanding the Chemical Diversity of the Antitumoral Compound Mithramycin by Combinatorial Biosynthesis and Biocatalysis: The Quest for Mithralogs with Improved Therapeutic Window.
    Méndez C; González-Sabín J; Morís F; Salas JA
    Planta Med; 2015 Oct; 81(15):1326-38. PubMed ID: 26393942
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The antitumor antibiotic mithramycin: new advanced approaches in modification and production.
    Kormanec J; Novakova R; Csolleiova D; Feckova L; Rezuchova B; Sevcikova B; Homerova D
    Appl Microbiol Biotechnol; 2020 Sep; 104(18):7701-7721. PubMed ID: 32686008
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin.
    Zabala D; Song L; Dashti Y; Challis GL; Salas JA; Méndez C
    Microb Cell Fact; 2020 May; 19(1):111. PubMed ID: 32448325
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Heterologous production of kasugamycin, an aminoglycoside antibiotic from Streptomyces kasugaensis, in Streptomyces lividans and Rhodococcus erythropolis L-88 by constitutive expression of the biosynthetic gene cluster.
    Kasuga K; Sasaki A; Matsuo T; Yamamoto C; Minato Y; Kuwahara N; Fujii C; Kobayashi M; Agematu H; Tamura T; Komatsu M; Ishikawa J; Ikeda H; Kojima I
    Appl Microbiol Biotechnol; 2017 May; 101(10):4259-4268. PubMed ID: 28243709
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Construction of the co-expression plasmids of fostriecin polyketide synthases and heterologous expression in Streptomyces.
    Su C; Zhao X; Qiu R; Tang L
    Pharm Biol; 2015 Feb; 53(2):269-74. PubMed ID: 25427408
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Heterologous production of daptomycin in Streptomyces lividans.
    Penn J; Li X; Whiting A; Latif M; Gibson T; Silva CJ; Brian P; Davies J; Miao V; Wrigley SK; Baltz RH
    J Ind Microbiol Biotechnol; 2006 Feb; 33(2):121-8. PubMed ID: 16261359
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Heterologous expression of pikromycin biosynthetic gene cluster using Streptomyces artificial chromosome system.
    Pyeon HR; Nah HJ; Kang SH; Choi SS; Kim ES
    Microb Cell Fact; 2017 May; 16(1):96. PubMed ID: 28569150
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Heterologous production of paromamine in Streptomyces lividans TK24 using kanamycin biosynthetic genes from Streptomyces kanamyceticus ATCC12853.
    Nepal KK; Oh TJ; Sohng JK
    Mol Cells; 2009 May; 27(5):601-8. PubMed ID: 19466609
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.
    Remsing LL; González AM; Nur-e-Alam M; Fernández-Lozano MJ; Braña AF; Rix U; Oliveira MA; Méndez C; Salas JA; Rohr J
    J Am Chem Soc; 2003 May; 125(19):5745-53. PubMed ID: 12733914
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.
    Lozano MJ; Remsing LL; Quirós LM; Braña AF; Fernández E; Sánchez C; Méndez C; Rohr J; Salas JA
    J Biol Chem; 2000 Feb; 275(5):3065-74. PubMed ID: 10652287
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.
    Kantola J; Blanco G; Hautala A; Kunnari T; Hakala J; Mendez C; Ylihonko K; Mäntsälä P; Salas J
    Chem Biol; 1997 Oct; 4(10):751-5. PubMed ID: 9375253
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Transcriptomic and fluxomic changes in Streptomyces lividans producing heterologous protein.
    Daniels W; Bouvin J; Busche T; Rückert C; Simoens K; Karamanou S; Van Mellaert L; Friðjónsson ÓH; Nicolai B; Economou A; Kalinowski J; Anné J; Bernaerts K
    Microb Cell Fact; 2018 Dec; 17(1):198. PubMed ID: 30577858
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster.
    Lombó F; Braña AF; Méndez C; Salas JA
    J Bacteriol; 1999 Jan; 181(2):642-7. PubMed ID: 9882681
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.
    Garcia-Bernardo J; Braña AF; Méndez C; Salas JA
    FEMS Microbiol Lett; 2000 May; 186(1):61-5. PubMed ID: 10779713
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.