BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

357 related articles for article (PubMed ID: 29203283)

  • 1. Understanding the structural and energetic basis of PD-1 and monoclonal antibodies bound to PD-L1: A molecular modeling perspective.
    Shi D; Zhou S; Liu X; Zhao C; Liu H; Yao X
    Biochim Biophys Acta Gen Subj; 2018 Mar; 1862(3):576-588. PubMed ID: 29203283
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Investigation of protein-protein interactions and hot spot region between PD-1 and PD-L1 by fragment molecular orbital method.
    Lim H; Chun J; Jin X; Kim J; Yoon J; No KT
    Sci Rep; 2019 Nov; 9(1):16727. PubMed ID: 31723178
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2.
    Zak KM; Grudnik P; Magiera K; Dömling A; Dubin G; Holak TA
    Structure; 2017 Aug; 25(8):1163-1174. PubMed ID: 28768162
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).
    Zak KM; Grudnik P; Guzik K; Zieba BJ; Musielak B; Dömling A; Dubin G; Holak TA
    Oncotarget; 2016 May; 7(21):30323-35. PubMed ID: 27083005
    [TBL] [Abstract][Full Text] [Related]  

  • 5. PD-L1 Nanobody Competitively Inhibits the Formation of the PD-1/PD-L1 Complex: Comparative Molecular Dynamics Simulations.
    Sun X; Yan X; Zhuo W; Gu J; Zuo K; Liu W; Liang L; Gan Y; He G; Wan H; Gou X; Shi H; Hu J
    Int J Mol Sci; 2018 Jul; 19(7):. PubMed ID: 29986511
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Characterization of PD-L1 binding sites by a combined FMO/GRID-DRY approach.
    Paciotti R; Agamennone M; Coletti C; Storchi L
    J Comput Aided Mol Des; 2020 Aug; 34(8):897-914. PubMed ID: 32185582
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of low-molecular weight anti-PD-L1 peptides for cancer immunotherapy.
    Liu H; Zhao Z; Zhang L; Li Y; Jain A; Barve A; Jin W; Liu Y; Fetse J; Cheng K
    J Immunother Cancer; 2019 Oct; 7(1):270. PubMed ID: 31640814
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-based derivation and intramolecular cyclization of peptide inhibitors from PD-1/PD-L1 complex interface as immune checkpoint blockade for breast cancer immunotherapy.
    Zhou K; Lu J; Yin X; Xu H; Li L; Ma B
    Biophys Chem; 2019 Oct; 253():106213. PubMed ID: 31276987
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular dynamics of the immune checkpoint programmed cell death protein I, PD-1: conformational changes of the BC-loop upon binding of the ligand PD-L1 and the monoclonal antibody nivolumab.
    Roither B; Oostenbrink C; Schreiner W
    BMC Bioinformatics; 2020 Dec; 21(Suppl 17):557. PubMed ID: 33308148
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular dynamics simulations elucidate conformational selection and induced fit mechanisms in the binding of PD-1 and PD-L1.
    Liu W; Huang B; Kuang Y; Liu G
    Mol Biosyst; 2017 May; 13(5):892-900. PubMed ID: 28327740
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular Modeling Studies on the Binding Mode of the PD-1/PD-L1 Complex Inhibitors.
    Almahmoud S; Zhong HA
    Int J Mol Sci; 2019 Sep; 20(18):. PubMed ID: 31546905
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Immune Checkpoint PD-1/PD-L1: Is There Life Beyond Antibodies?
    Konstantinidou M; Zarganes-Tzitzikas T; Magiera-Mularz K; Holak TA; Dömling A
    Angew Chem Int Ed Engl; 2018 Apr; 57(18):4840-4848. PubMed ID: 29178534
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Protein Footprinting and X-ray Crystallography Reveal the Interaction of PD-L1 and a Macrocyclic Peptide.
    Niu B; Appleby TC; Wang R; Morar M; Voight J; Villaseñor AG; Clancy S; Wise S; Belzile JP; Papalia G; Wong M; Brendza KM; Lad L; Gross ML
    Biochemistry; 2020 Feb; 59(4):541-551. PubMed ID: 31841311
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Development of the Inhibitors that Target the PD-1/PD-L1 Interaction-A Brief Look at Progress on Small Molecules, Peptides and Macrocycles.
    Guzik K; Tomala M; Muszak D; Konieczny M; Hec A; Błaszkiewicz U; Pustuła M; Butera R; Dömling A; Holak TA
    Molecules; 2019 May; 24(11):. PubMed ID: 31151293
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1.
    Zak KM; Kitel R; Przetocka S; Golik P; Guzik K; Musielak B; Dömling A; Dubin G; Holak TA
    Structure; 2015 Dec; 23(12):2341-2348. PubMed ID: 26602187
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Probing protein flexibility reveals a mechanism for selective promiscuity.
    Pabon NA; Camacho CJ
    Elife; 2017 Apr; 6():. PubMed ID: 28432789
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pharmacophore model of immunocheckpoint protein PD-L1 by cosolvent molecular dynamics simulations.
    Mejías C; Guirola O
    J Mol Graph Model; 2019 Sep; 91():105-111. PubMed ID: 31202914
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1.
    Guzik K; Zak KM; Grudnik P; Magiera K; Musielak B; Törner R; Skalniak L; Dömling A; Dubin G; Holak TA
    J Med Chem; 2017 Jul; 60(13):5857-5867. PubMed ID: 28613862
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Symmetry-based ligand design and evaluation of small molecule inhibitors of programmed cell death-1/programmed death-ligand 1 interaction.
    Kawashita S; Aoyagi K; Yamanaka H; Hantani R; Naruoka S; Tanimoto A; Hori Y; Toyonaga Y; Fukushima K; Miyazaki S; Hantani Y
    Bioorg Med Chem Lett; 2019 Sep; 29(17):2464-2467. PubMed ID: 31351692
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Residue-specific binding mechanisms of PD-L1 to its monoclonal antibodies by computational alanine scanning.
    Wen W; Huang D; Bao J; Zhang JZH
    Phys Chem Chem Phys; 2021 Jul; 23(29):15591-15600. PubMed ID: 34259259
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.