BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

319 related articles for article (PubMed ID: 29209046)

  • 1. Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer.
    Cheng AN; Fan CC; Lo YK; Kuo CL; Wang HC; Lien IH; Lin SY; Chen CH; Jiang SS; Chang IS; Juan HF; Lyu PC; Lee AY
    Sci Rep; 2017 Dec; 7(1):17024. PubMed ID: 29209046
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.
    Lee AY; Chiba T; Truong LN; Cheng AN; Do J; Cho MJ; Chen L; Wu X
    J Biol Chem; 2012 Jan; 287(4):2531-43. PubMed ID: 22123827
    [TBL] [Abstract][Full Text] [Related]  

  • 3. ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress.
    Yamada M; Watanabe K; Mistrik M; Vesela E; Protivankova I; Mailand N; Lee M; Masai H; Lukas J; Bartek J
    Genes Dev; 2013 Nov; 27(22):2459-72. PubMed ID: 24240236
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The role of the Saccharomyces cerevisiae Cdc7-Dbf4 complex in the replication checkpoint.
    Ogi H; Wang CZ; Nakai W; Kawasaki Y; Masumoto H
    Gene; 2008 May; 414(1-2):32-40. PubMed ID: 18372119
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Increased Cdc7 expression is a marker of oral squamous cell carcinoma and overexpression of Cdc7 contributes to the resistance to DNA-damaging agents.
    Cheng AN; Jiang SS; Fan CC; Lo YK; Kuo CY; Chen CH; Liu YL; Lee CC; Chen WS; Huang TS; Wang TY; Lee AY
    Cancer Lett; 2013 Sep; 337(2):218-25. PubMed ID: 23684929
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Regulation and roles of Cdc7 kinase under replication stress.
    Yamada M; Masai H; Bartek J
    Cell Cycle; 2014; 13(12):1859-66. PubMed ID: 24841992
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage.
    Ha K; Fiskus W; Rao R; Balusu R; Venkannagari S; Nalabothula NR; Bhalla KN
    Mol Cancer Ther; 2011 Jul; 10(7):1194-206. PubMed ID: 21566061
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer.
    Guo Y; Wang J; Benedict B; Yang C; van Gemert F; Ma X; Gao D; Wang H; Zhang S; Lieftink C; Beijersbergen RL; Te Riele H; Qiao X; Gao Q; Sun C; Qin W; Bernards R; Wang C
    Genome Med; 2021 Oct; 13(1):166. PubMed ID: 34663432
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells.
    Charych DH; Coyne M; Yabannavar A; Narberes J; Chow S; Wallroth M; Shafer C; Walter AO
    J Cell Biochem; 2008 Jun; 104(3):1075-86. PubMed ID: 18286467
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Xenopus CDC7/DRF1 complex is required for the initiation of DNA replication.
    Silva T; Bradley RH; Gao Y; Coue M
    J Biol Chem; 2006 Apr; 281(17):11569-76. PubMed ID: 16507577
    [TBL] [Abstract][Full Text] [Related]  

  • 11. HCLK2 is required for activity of the DNA damage response kinase ATR.
    Rendtlew Danielsen JM; Larsen DH; Schou KB; Freire R; Falck J; Bartek J; Lukas J
    J Biol Chem; 2009 Feb; 284(7):4140-7. PubMed ID: 19097996
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Maturation-associated Dbf4 expression is essential for mouse zygotic DNA replication.
    Murai S; Katagiri Y; Yamashita S
    Dev Growth Differ; 2014 Dec; 56(9):625-39. PubMed ID: 25348865
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cdc7 activates replication checkpoint by phosphorylating the Chk1-binding domain of Claspin in human cells.
    Yang CC; Kato H; Shindo M; Masai H
    Elife; 2019 Dec; 8():. PubMed ID: 31889509
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly.
    Bruck I; Kaplan DL
    J Biol Chem; 2015 Jan; 290(2):1210-21. PubMed ID: 25471369
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.
    Kim JM; Kakusho N; Yamada M; Kanoh Y; Takemoto N; Masai H
    Oncogene; 2008 May; 27(24):3475-82. PubMed ID: 18084324
    [TBL] [Abstract][Full Text] [Related]  

  • 16. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication.
    Costanzo V; Shechter D; Lupardus PJ; Cimprich KA; Gottesman M; Gautier J
    Mol Cell; 2003 Jan; 11(1):203-13. PubMed ID: 12535533
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.
    Tsuji T; Ficarro SB; Jiang W
    Mol Biol Cell; 2006 Oct; 17(10):4459-72. PubMed ID: 16899510
    [TBL] [Abstract][Full Text] [Related]  

  • 18. High levels of Cdc7 and Dbf4 proteins can arrest cell-cycle progression.
    Guo B; Romero J; Kim BJ; Lee H
    Eur J Cell Biol; 2005 Dec; 84(12):927-38. PubMed ID: 16325502
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells.
    Rodríguez-Bravo V; Guaita-Esteruelas S; Florensa R; Bachs O; Agell N
    Cancer Res; 2006 Sep; 66(17):8672-9. PubMed ID: 16951182
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.
    Smith J; Tho LM; Xu N; Gillespie DA
    Adv Cancer Res; 2010; 108():73-112. PubMed ID: 21034966
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.