These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

218 related articles for article (PubMed ID: 29222481)

  • 1. Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways.
    Ullah K; Rosendahl AH; Izzi V; Bergmann U; Pihlajaniemi T; Mäki JM; Myllyharju J
    Sci Rep; 2017 Dec; 7(1):17220. PubMed ID: 29222481
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Notch Downregulation and Extramedullary Erythrocytosis in Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2-Deficient Mice.
    Myllymäki MNM; Määttä J; Dimova EY; Izzi V; Väisänen T; Myllyharju J; Koivunen P; Serpi R
    Mol Cell Biol; 2017 Jan; 37(2):. PubMed ID: 27821476
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia.
    Rosendahl AH; Monnius M; Laitala A; Railo A; Miinalainen I; Heljasvaara R; Mäki JM; Myllyharju J
    J Biol Chem; 2022 Apr; 298(4):101787. PubMed ID: 35247391
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis.
    Rahtu-Korpela L; Määttä J; Dimova EY; Hörkkö S; Gylling H; Walkinshaw G; Hakkola J; Kivirikko KI; Myllyharju J; Serpi R; Koivunen P
    Arterioscler Thromb Vasc Biol; 2016 Apr; 36(4):608-17. PubMed ID: 26848160
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner.
    Fitzpatrick SF; Fábián Z; Schaible B; Lenihan CR; Schwarzl T; Rodriguez J; Zheng X; Li Z; Tambuwala MM; Higgins DG; O'Meara Y; Slattery C; Manresa MC; Fraisl P; Bruning U; Baes M; Carmeliet P; Doherty G; von Kriegsheim A; Cummins EP; Taylor CT
    Biochem Biophys Res Commun; 2016 Jun; 474(3):579-586. PubMed ID: 27130823
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Expression and Roles of Individual HIF Prolyl 4-Hydroxylase Isoenzymes in the Regulation of the Hypoxia Response Pathway along the Murine Gastrointestinal Epithelium.
    Dengler F; Sova S; Salo AM; Mäki JM; Koivunen P; Myllyharju J
    Int J Mol Sci; 2021 Apr; 22(8):. PubMed ID: 33919829
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway.
    Shin J; Nunomiya A; Kitajima Y; Dan T; Miyata T; Nagatomi R
    Skelet Muscle; 2016; 6():5. PubMed ID: 26949511
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease.
    Laitakari A; Ollonen T; Kietzmann T; Walkinshaw G; Mennerich D; Izzi V; Haapasaari KM; Myllyharju J; Serpi R; Dimova EY; Koivunen P
    Redox Biol; 2019 Apr; 22():101145. PubMed ID: 30802717
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.
    Marxsen JH; Stengel P; Doege K; Heikkinen P; Jokilehto T; Wagner T; Jelkmann W; Jaakkola P; Metzen E
    Biochem J; 2004 Aug; 381(Pt 3):761-7. PubMed ID: 15104534
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1alpha.
    Shin DH; Li SH; Yang SW; Lee BL; Lee MK; Park JW
    FEBS J; 2009 Jul; 276(13):3470-80. PubMed ID: 19456861
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.
    Scholz CC; Cavadas MA; Tambuwala MM; Hams E; Rodríguez J; von Kriegsheim A; Cotter P; Bruning U; Fallon PG; Cheong A; Cummins EP; Taylor CT
    Proc Natl Acad Sci U S A; 2013 Nov; 110(46):18490-5. PubMed ID: 24145445
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Activation of the hypoxia response pathway protects against age-induced cardiac hypertrophy.
    Röning T; Magga J; Laitakari A; Halmetoja R; Tapio J; Dimova EY; Szabo Z; Rahtu-Korpela L; Kemppi A; Walkinshaw G; Myllyharju J; Kerkelä R; Koivunen P; Serpi R
    J Mol Cell Cardiol; 2022 Mar; 164():148-155. PubMed ID: 34919895
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Systemic long-term inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 ameliorates aging-induced changes in mice without affecting their life span.
    Laitakari A; Huttunen R; Kuvaja P; Hannuksela P; Szabo Z; Heikkilä M; Kerkelä R; Myllyharju J; Dimova EY; Serpi R; Koivunen P
    FASEB J; 2020 Apr; 34(4):5590-5609. PubMed ID: 32100354
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression.
    Takeda K; Ichiki T; Narabayashi E; Inanaga K; Miyazaki R; Hashimoto T; Matsuura H; Ikeda J; Miyata T; Sunagawa K
    Arterioscler Thromb Vasc Biol; 2009 Dec; 29(12):2132-7. PubMed ID: 19762779
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Genetic Knockdown and Pharmacologic Inhibition of Hypoxia-Inducible Factor (HIF) Hydroxylases.
    Pickel C; Taylor CT; Scholz CC
    Methods Mol Biol; 2018; 1742():1-14. PubMed ID: 29330785
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor.
    Kiriakidis S; Hoer SS; Burrows N; Biddlecome G; Khan MN; Thinnes CC; Schofield CJ; Rogers N; Botto M; Paleolog E; Maxwell PH
    Kidney Int; 2017 Oct; 92(4):900-908. PubMed ID: 28506759
    [TBL] [Abstract][Full Text] [Related]  

  • 17. HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury.
    Karsikas S; Myllymäki M; Heikkilä M; Sormunen R; Kivirikko KI; Myllyharju J; Serpi R; Koivunen P
    J Mol Med (Berl); 2016 Mar; 94(3):301-10. PubMed ID: 26452676
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Lack of P4H-TM in mice results in age-related retinal and renal alterations.
    Leinonen H; Rossi M; Salo AM; Tiainen P; Hyvärinen J; Pitkänen M; Sormunen R; Miinalainen I; Zhang C; Soininen R; Kivirikko KI; Koskelainen A; Tanila H; Myllyharju J; Koivunen P
    Hum Mol Genet; 2016 Sep; 25(17):3810-3823. PubMed ID: 27466183
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Hypoxia-Inducible Factor Prolyl 4-Hydroxylases and Metabolism.
    Koivunen P; Kietzmann T
    Trends Mol Med; 2018 Dec; 24(12):1021-1035. PubMed ID: 30391126
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.
    Hou P; Kuo CY; Cheng CT; Liou JP; Ann DK; Chen Q
    PLoS One; 2014; 9(11):e113865. PubMed ID: 25420025
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.