These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

506 related articles for article (PubMed ID: 29223392)

  • 1. Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology.
    Fujimoto T; Kuwahara T; Eguchi T; Sakurai M; Komori T; Iwatsubo T
    Biochem Biophys Res Commun; 2018 Jan; 495(2):1708-1715. PubMed ID: 29223392
    [TBL] [Abstract][Full Text] [Related]  

  • 2. LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.
    Liu Z; Bryant N; Kumaran R; Beilina A; Abeliovich A; Cookson MR; West AB
    Hum Mol Genet; 2018 Jan; 27(2):385-395. PubMed ID: 29177506
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.
    Purlyte E; Dhekne HS; Sarhan AR; Gomez R; Lis P; Wightman M; Martinez TN; Tonelli F; Pfeffer SR; Alessi DR
    EMBO J; 2018 Jan; 37(1):1-18. PubMed ID: 29212815
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration.
    Jeong GR; Jang EH; Bae JR; Jun S; Kang HC; Park CH; Shin JH; Yamamoto Y; Tanaka-Yamamoto K; Dawson VL; Dawson TM; Hur EM; Lee BD
    Mol Neurodegener; 2018 Feb; 13(1):8. PubMed ID: 29439717
    [TBL] [Abstract][Full Text] [Related]  

  • 5. LRRK2 and Parkinson's Disease: From Lack of Structure to Gain of Function.
    Blanca Ramírez M; Madero-Perez J; Rivero-Rios P; Martinez-Salvador M; Lara Ordonez AJ; Fernandez B; Fdez E; Hilfiker S
    Curr Protein Pept Sci; 2017; 18(7):677-686. PubMed ID: 26965688
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cellular effects mediated by pathogenic LRRK2: homing in on Rab-mediated processes.
    Madero-Pérez J; Fdez E; Fernández B; Lara Ordóñez AJ; Blanca Ramírez M; Romo Lozano M; Rivero-Ríos P; Hilfiker S
    Biochem Soc Trans; 2017 Feb; 45(1):147-154. PubMed ID: 28202668
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.
    Beilina A; Bonet-Ponce L; Kumaran R; Kordich JJ; Ishida M; Mamais A; Kaganovich A; Saez-Atienzar S; Gershlick DC; Roosen DA; Pellegrini L; Malkov V; Fell MJ; Harvey K; Bonifacino JS; Moore DJ; Cookson MR
    Cell Rep; 2020 May; 31(5):107614. PubMed ID: 32375042
    [TBL] [Abstract][Full Text] [Related]  

  • 8. P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity.
    Kalogeropulou AF; Zhao J; Bolliger MF; Memou A; Narasimha S; Molitor TP; Wilson WH; Rideout HJ; Nichols RJ
    Biochem J; 2018 Apr; 475(7):1271-1293. PubMed ID: 29519959
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.
    Malik AU; Karapetsas A; Nirujogi RS; Mathea S; Chatterjee D; Pal P; Lis P; Taylor M; Purlyte E; Gourlay R; Dorward M; Weidlich S; Toth R; Polinski NK; Knapp S; Tonelli F; Alessi DR
    Biochem J; 2021 Feb; 478(3):553-578. PubMed ID: 33459343
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
    Madero-Pérez J; Fdez E; Fernández B; Lara Ordóñez AJ; Blanca Ramírez M; Gómez-Suaga P; Waschbüsch D; Lobbestael E; Baekelandt V; Nairn AC; Ruiz-Martínez J; Aiastui A; López de Munain A; Lis P; Comptdaer T; Taymans JM; Chartier-Harlin MC; Beilina A; Gonnelli A; Cookson MR; Greggio E; Hilfiker S
    Mol Neurodegener; 2018 Jan; 13(1):3. PubMed ID: 29357897
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
    Mir R; Tonelli F; Lis P; Macartney T; Polinski NK; Martinez TN; Chou MY; Howden AJM; König T; Hotzy C; Milenkovic I; Brücke T; Zimprich A; Sammler E; Alessi DR
    Biochem J; 2018 Jun; 475(11):1861-1883. PubMed ID: 29743203
    [TBL] [Abstract][Full Text] [Related]  

  • 12. LRRK2 and Rab GTPases.
    Pfeffer SR
    Biochem Soc Trans; 2018 Dec; 46(6):1707-1712. PubMed ID: 30467121
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Development of phospho-specific Rab protein antibodies to monitor
    Lis P; Burel S; Steger M; Mann M; Brown F; Diez F; Tonelli F; Holton JL; Ho PW; Ho SL; Chou MY; Polinski NK; Martinez TN; Davies P; Alessi DR
    Biochem J; 2018 Jan; 475(1):1-22. PubMed ID: 29127256
    [TBL] [Abstract][Full Text] [Related]  

  • 14. GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.
    Blanca Ramírez M; Lara Ordóñez AJ; Fdez E; Madero-Pérez J; Gonnelli A; Drouyer M; Chartier-Harlin MC; Taymans JM; Bubacco L; Greggio E; Hilfiker S
    Hum Mol Genet; 2017 Jul; 26(14):2747-2767. PubMed ID: 28453723
    [TBL] [Abstract][Full Text] [Related]  

  • 15. ULK1 and JNK are involved in mitophagy incurred by LRRK2 G2019S expression.
    Zhu Y; Wang C; Yu M; Cui J; Liu L; Xu Z
    Protein Cell; 2013 Sep; 4(9):711-21. PubMed ID: 27023913
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Detection of Substrate Phosphorylation of LRRK2 in Tissues and Cultured Cells.
    Ito K; Xu L; Ito G; Tomita T
    Methods Mol Biol; 2021; 2322():53-61. PubMed ID: 34043192
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Kinase activity of mutant LRRK2 manifests differently in hetero-dimeric vs. homo-dimeric complexes.
    Leandrou E; Markidi E; Memou A; Melachroinou K; Greggio E; Rideout HJ
    Biochem J; 2019 Feb; 476(3):559-579. PubMed ID: 30670570
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.
    Krumova P; Reyniers L; Meyer M; Lobbestael E; Stauffer D; Gerrits B; Muller L; Hoving S; Kaupmann K; Voshol J; Fabbro D; Bauer A; Rovelli G; Taymans JM; Bouwmeester T; Baekelandt V
    FASEB J; 2015 Jul; 29(7):2980-92. PubMed ID: 25854701
    [TBL] [Abstract][Full Text] [Related]  

  • 19. LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
    Eguchi T; Kuwahara T; Sakurai M; Komori T; Fujimoto T; Ito G; Yoshimura SI; Harada A; Fukuda M; Koike M; Iwatsubo T
    Proc Natl Acad Sci U S A; 2018 Sep; 115(39):E9115-E9124. PubMed ID: 30209220
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease.
    Cookson MR
    Biochem Soc Trans; 2016 Dec; 44(6):1603-1610. PubMed ID: 27913668
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 26.