These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

130 related articles for article (PubMed ID: 29223807)

  • 1. Design, synthesis, and biological evaluation of deuterated phenylpropionic acid derivatives as potent and long-acting free fatty acid receptor 1 agonists.
    Li Z; Liu C; Xu X; Shi W; Li H; Dai Y; Cai X; Huang W; Qian H
    Bioorg Chem; 2018 Feb; 76():303-313. PubMed ID: 29223807
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Improving metabolic stability with deuterium: The discovery of HWL-066, a potent and long-acting free fatty acid receptor 1 agonists.
    Liu C; Li Z; Shi W; Li H; Wang N; Dai Y; Liao C; Huang W; Qian H
    Chem Biol Drug Des; 2018 Aug; 92(2):1547-1554. PubMed ID: 29777569
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Improving metabolic stability with deuterium: The discovery of GPU-028, a potent free fatty acid receptor 4 agonists.
    Li Z; Xu X; Li G; Fu X; Liu Y; Feng Y; Wang M; Ouyang Y; Han J
    Bioorg Med Chem; 2017 Dec; 25(24):6647-6652. PubMed ID: 29100735
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and biological activity of deuterium-based FFA1 agonists with improved pharmacokinetic profiles.
    Liu B; Deng L; Chen H; Liao R; Li Y; Zeng X; Deng F; Zhang L; Li Z
    Bioorg Med Chem Lett; 2019 Jun; 29(12):1471-1475. PubMed ID: 30992164
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of highly potent and orally available free fatty acid receptor 1 agonists bearing isoxazole scaffold.
    Li Z; Liu C; Shi W; Cai X; Dai Y; Liao C; Huang W; Qian H
    Bioorg Med Chem; 2018 Feb; 26(3):703-711. PubMed ID: 29291938
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.
    Li Z; Liu C; Xu X; Qiu Q; Su X; Dai Y; Yang J; Li H; Shi W; Liao C; Pan M; Huang W; Qian H
    Eur J Med Chem; 2017 Sep; 138():458-479. PubMed ID: 28689096
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis, and biological activity of potent and orally available G protein-coupled receptor 40 agonists.
    Sasaki S; Kitamura S; Negoro N; Suzuki M; Tsujihata Y; Suzuki N; Santou T; Kanzaki N; Harada M; Tanaka Y; Kobayashi M; Tada N; Funami M; Tanaka T; Yamamoto Y; Fukatsu K; Yasuma T; Momose Y
    J Med Chem; 2011 Mar; 54(5):1365-78. PubMed ID: 21319751
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis, and biological evaluations of phenylpropiolic acid derivatives as novel GPR40 agonists.
    Jiang XW; Jiang BE; Liu H; Liu ZT; Hu LL; Liu M; Lu W; Zhang HK
    Eur J Med Chem; 2018 Oct; 158():123-133. PubMed ID: 30212763
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine.
    Kong D; Guo S; Yang Y; Guo B; Xie X; Hu W
    Bioorg Med Chem Lett; 2019 Mar; 29(6):848-852. PubMed ID: 30685095
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists.
    Zhang X; Cai C; Winters M; Wells M; Wall M; Lanter J; Sui Z; Ma J; Novack A; Nashashibi I; Wang Y; Yan W; Suckow A; Hua H; Bell A; Haug P; Clapper W; Jenkinson C; Gunnet J; Leonard J; Murray WV
    Bioorg Med Chem Lett; 2017 Aug; 27(15):3272-3278. PubMed ID: 28642104
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties.
    Christiansen E; Urban C; Grundmann M; Due-Hansen ME; Hagesaether E; Schmidt J; Pardo L; Ullrich S; Kostenis E; Kassack M; Ulven T
    J Med Chem; 2011 Oct; 54(19):6691-703. PubMed ID: 21854074
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, and evaluation of a series of novel phenylpropanoic acid derivatives agonists for the FFA1.
    Yang J; Gu E; Yan T; Shen D; Feng B; Tang C
    Chem Biol Drug Des; 2019 May; 93(5):900-909. PubMed ID: 30657643
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis, and biological evaluation of novel dual FFA1 (GPR40)/PPARδ agonists as potential anti-diabetic agents.
    Li Z; Hu L; Wang X; Zhou Z; Deng L; Xu Y; Zhang L
    Bioorg Chem; 2019 Nov; 92():103254. PubMed ID: 31518760
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes.
    Mikami S; Kitamura S; Negoro N; Sasaki S; Suzuki M; Tsujihata Y; Miyazaki T; Ito R; Suzuki N; Miyazaki J; Santou T; Kanzaki N; Funami M; Tanaka T; Yasuma T; Momose Y
    J Med Chem; 2012 Apr; 55(8):3756-76. PubMed ID: 22428944
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy.
    Hansen SV; Christiansen E; Urban C; Hudson BD; Stocker CJ; Due-Hansen ME; Wargent ET; Shimpukade B; Almeida R; Ejsing CS; Cawthorne MA; Kassack MU; Milligan G; Ulven T
    J Med Chem; 2016 Mar; 59(6):2841-6. PubMed ID: 26928019
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and biological activity of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists.
    Li Z; Wang X; Xu X; Yang J; Xia W; Zhou X; Huang W; Qian H
    Bioorg Med Chem; 2015 Nov; 23(22):7158-64. PubMed ID: 26482570
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Exploring bulky natural and natural-like periphery in the design of p-(benzyloxy)phenylpropionic acid agonists of free fatty acid receptor 1 (GPR40).
    Kuranov SO; Luzina OA; Onopchenko O; Pishel I; Zozulya S; Gureev M; Salakhutdinov NF; Krasavin M
    Bioorg Chem; 2020 Jun; 99():103830. PubMed ID: 32289588
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold.
    Zhou Z; Cai Z; Zhang C; Yang B; Chen L; He Y; Zhang L; Li Z
    Bioorg Med Chem; 2022 Feb; 56():116615. PubMed ID: 35051813
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists.
    Song F; Lu S; Gunnet J; Xu JZ; Wines P; Proost J; Liang Y; Baumann C; Lenhard J; Murray WV; Demarest KT; Kuo GH
    J Med Chem; 2007 Jun; 50(12):2807-17. PubMed ID: 17500511
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis and Structure-activity relationship studies of new thiazole-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.
    Li Z; Qiu Q; Xu X; Wang X; Jiao L; Su X; Pan M; Huang W; Qian H
    Eur J Med Chem; 2016 May; 113():246-57. PubMed ID: 26945112
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.