BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

246 related articles for article (PubMed ID: 29229779)

  • 1. Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity.
    Sharma P; Kranz DM
    J Biol Chem; 2018 Feb; 293(5):1820-1834. PubMed ID: 29229779
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes.
    Smith SN; Sommermeyer D; Piepenbrink KH; Blevins SJ; Bernhard H; Uckert W; Baker BM; Kranz DM
    J Mol Biol; 2013 Nov; 425(22):4496-507. PubMed ID: 23954306
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Changing the peptide specificity of a human T-cell receptor by directed evolution.
    Smith SN; Wang Y; Baylon JL; Singh NK; Baker BM; Tajkhorshid E; Kranz DM
    Nat Commun; 2014 Nov; 5():5223. PubMed ID: 25376839
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex.
    Harris DT; Wang N; Riley TP; Anderson SD; Singh NK; Procko E; Baker BM; Kranz DM
    J Biol Chem; 2016 Nov; 291(47):24566-24578. PubMed ID: 27681597
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural basis for ineffective T-cell responses to MHC anchor residue-improved "heteroclitic" peptides.
    Madura F; Rizkallah PJ; Holland CJ; Fuller A; Bulek A; Godkin AJ; Schauenburg AJ; Cole DK; Sewell AK
    Eur J Immunol; 2015 Feb; 45(2):584-91. PubMed ID: 25471691
    [TBL] [Abstract][Full Text] [Related]  

  • 6. High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3.
    Chlewicki LK; Holler PD; Monti BC; Clutter MR; Kranz DM
    J Mol Biol; 2005 Feb; 346(1):223-39. PubMed ID: 15663940
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Specific roles of each TCR hemichain in generating functional chain-centric TCR.
    Nakatsugawa M; Yamashita Y; Ochi T; Tanaka S; Chamoto K; Guo T; Butler MO; Hirano N
    J Immunol; 2015 Apr; 194(7):3487-500. PubMed ID: 25710913
    [TBL] [Abstract][Full Text] [Related]  

  • 8. T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.
    Cole DK; Miles KM; Madura F; Holland CJ; Schauenburg AJ; Godkin AJ; Bulek AM; Fuller A; Akpovwa HJ; Pymm PG; Liddy N; Sami M; Li Y; Rizkallah PJ; Jakobsen BK; Sewell AK
    J Biol Chem; 2014 Jan; 289(2):628-38. PubMed ID: 24196962
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Computational design of the affinity and specificity of a therapeutic T cell receptor.
    Pierce BG; Hellman LM; Hossain M; Singh NK; Vander Kooi CW; Weng Z; Baker BM
    PLoS Comput Biol; 2014 Feb; 10(2):e1003478. PubMed ID: 24550723
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The basis for limited specificity and MHC restriction in a T cell receptor interface.
    Piepenbrink KH; Blevins SJ; Scott DR; Baker BM
    Nat Commun; 2013; 4():1948. PubMed ID: 23736024
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions.
    Robbins PF; Li YF; El-Gamil M; Zhao Y; Wargo JA; Zheng Z; Xu H; Morgan RA; Feldman SA; Johnson LA; Bennett AD; Dunn SM; Mahon TM; Jakobsen BK; Rosenberg SA
    J Immunol; 2008 May; 180(9):6116-31. PubMed ID: 18424733
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Topology of T cell receptor-peptide/class I MHC interaction defined by charge reversal complementation and functional analysis.
    Chang HC; Smolyar A; Spoerl R; Witte T; Yao Y; Goyarts EC; Nathenson SG; Reinherz EL
    J Mol Biol; 1997 Aug; 271(2):278-93. PubMed ID: 9268659
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments.
    Richman SA; Aggen DH; Dossett ML; Donermeyer DL; Allen PM; Greenberg PD; Kranz DM
    Mol Immunol; 2009 Feb; 46(5):902-16. PubMed ID: 18962897
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity.
    Stadinski BD; Trenh P; Duke B; Huseby PG; Li G; Stern LJ; Huseby ES
    J Immunol; 2014 Jun; 192(12):6071-82. PubMed ID: 24813203
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Residues outside of the HLA-A2 peptide-binding groove can abrogate or enhance recognition of influenza virus matrix peptide pulsed cells by cytotoxic T lymphocytes.
    Teng JM; Hogan KT
    Mol Immunol; 1994 Apr; 31(6):445-57. PubMed ID: 8183283
    [TBL] [Abstract][Full Text] [Related]  

  • 16. High affinity T cell receptors from yeast display libraries block T cell activation by superantigens.
    Kieke MC; Sundberg E; Shusta EV; Mariuzza RA; Wittrup KD; Kranz DM
    J Mol Biol; 2001 Apr; 307(5):1305-15. PubMed ID: 11292343
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2.
    Gao GF; Tormo J; Gerth UC; Wyer JR; McMichael AJ; Stuart DI; Bell JI; Jones EY; Jakobsen BK
    Nature; 1997 Jun; 387(6633):630-4. PubMed ID: 9177355
    [TBL] [Abstract][Full Text] [Related]  

  • 18. T-Cell Receptor CDR3 Loop Conformations in Solution Shift the Relative Vα-Vβ Domain Distributions.
    Fernández-Quintero ML; Pomarici ND; Loeffler JR; Seidler CA; Liedl KR
    Front Immunol; 2020; 11():1440. PubMed ID: 32733478
    [TBL] [Abstract][Full Text] [Related]  

  • 19. How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire.
    Blevins SJ; Pierce BG; Singh NK; Riley TP; Wang Y; Spear TT; Nishimura MI; Weng Z; Baker BM
    Proc Natl Acad Sci U S A; 2016 Mar; 113(9):E1276-85. PubMed ID: 26884163
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Amino acid substitutions at position 97 in HLA-A2 segregate cytolysis from cytokine release in MART-1/Melan-A peptide AAGIGILTV-specific cytotoxic T lymphocytes.
    Maeurer MJ; Chan HW; Karbach J; Salter RD; Knuth A; Lotze MT; Storkus WJ
    Eur J Immunol; 1996 Nov; 26(11):2613-23. PubMed ID: 8921947
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.