BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

280 related articles for article (PubMed ID: 29243930)

  • 1. Structure-Based Kinase Profiling To Understand the Polypharmacological Behavior of Therapeutic Molecules.
    Dutta D; Das R; Mandal C; Mandal C
    J Chem Inf Model; 2018 Jan; 58(1):68-89. PubMed ID: 29243930
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Modeling Polypharmacological Profiles by Affinity Fingerprinting.
    Peragovics A; Simon Z; Malnasi-Csizmadia A; Bender A
    Curr Pharm Des; 2016; 22(46):6885-6894. PubMed ID: 27587199
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-based grafting and identification of kinase-inhibitors to target mTOR signaling pathway as potential therapeutics for glioblastoma.
    Cui YH; Chen J; Xu T; Tian HL
    Comput Biol Chem; 2015 Feb; 54():57-65. PubMed ID: 25625417
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery.
    Ravikumar B; Aittokallio T
    Expert Opin Drug Discov; 2018 Feb; 13(2):179-192. PubMed ID: 29233023
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Profile-QSAR: a novel meta-QSAR method that combines activities across the kinase family to accurately predict affinity, selectivity, and cellular activity.
    Martin E; Mukherjee P; Sullivan D; Jansen J
    J Chem Inf Model; 2011 Aug; 51(8):1942-56. PubMed ID: 21667971
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Rational creation and systematic analysis of cervical cancer kinase-inhibitor binding profile.
    Han M; Sun D
    J Comput Aided Mol Des; 2019 Jul; 33(7):689-698. PubMed ID: 31203490
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Multi-Targeting Bioactive Compounds Extracted from Essential Oils as Kinase Inhibitors.
    Maruca A; Lanzillotta D; Rocca R; Lupia A; Costa G; Catalano R; Moraca F; Gaudio E; Ortuso F; Artese A; Trapasso F; Alcaro S
    Molecules; 2020 May; 25(9):. PubMed ID: 32384767
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Prediction of polypharmacological profiles of drugs by the integration of chemical, side effect, and therapeutic space.
    Cheng F; Li W; Wu Z; Wang X; Zhang C; Li J; Liu G; Tang Y
    J Chem Inf Model; 2013 Apr; 53(4):753-62. PubMed ID: 23527559
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Drugs Polypharmacology by In Silico Methods: New Opportunities in Drug Discovery.
    Lauria A; Bonsignore R; Bartolotta R; Perricone U; Martorana A; Gentile C
    Curr Pharm Des; 2016; 22(21):3073-81. PubMed ID: 26907944
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Integrating ligand-based and protein-centric virtual screening of kinase inhibitors using ensembles of multiple protein kinase genes and conformations.
    Dixit A; Verkhivker GM
    J Chem Inf Model; 2012 Oct; 52(10):2501-15. PubMed ID: 22992037
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Rational screening of peroxisome proliferator-activated receptor-γ agonists from natural products: potential therapeutics for heart failure.
    Chen R; Wan J; Song J; Qian Y; Liu Y; Gu S
    Pharm Biol; 2017 Dec; 55(1):503-509. PubMed ID: 27937122
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The Human Kinome Targeted by FDA Approved Multi-Target Drugs and Combination Products: A Comparative Study from the Drug-Target Interaction Network Perspective.
    Li YH; Wang PP; Li XX; Yu CY; Yang H; Zhou J; Xue WW; Tan J; Zhu F
    PLoS One; 2016; 11(11):e0165737. PubMed ID: 27828998
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
    Gao Y; Davies SP; Augustin M; Woodward A; Patel UA; Kovelman R; Harvey KJ
    Biochem J; 2013 Apr; 451(2):313-28. PubMed ID: 23398362
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies.
    Ravikumar B; Timonen S; Alam Z; Parri E; Wennerberg K; Aittokallio T
    Cell Chem Biol; 2019 Nov; 26(11):1608-1622.e6. PubMed ID: 31521622
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors.
    Reyes-Parada M; Iturriaga-Vasquez P
    Expert Opin Drug Discov; 2016 Oct; 11(10):969-81. PubMed ID: 27552487
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel inhibitor discovery through virtual screening against multiple protein conformations generated via ligand-directed modeling: a maternal embryonic leucine zipper kinase example.
    Mahasenan KV; Li C
    J Chem Inf Model; 2012 May; 52(5):1345-55. PubMed ID: 22540736
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of multitarget-directed ligands against Alzheimer's disease through systematic prediction of chemical-protein interactions.
    Fang J; Li Y; Liu R; Pang X; Li C; Yang R; He Y; Lian W; Liu AL; Du GH
    J Chem Inf Model; 2015 Jan; 55(1):149-64. PubMed ID: 25531792
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Enhancing Virtual Screening Performance of Protein Kinases with Molecular Dynamics Simulations.
    Offutt TL; Swift RV; Amaro RE
    J Chem Inf Model; 2016 Oct; 56(10):1923-1935. PubMed ID: 27662181
    [TBL] [Abstract][Full Text] [Related]  

  • 19. DFGmodel: predicting protein kinase structures in inactive states for structure-based discovery of type-II inhibitors.
    Ung PM; Schlessinger A
    ACS Chem Biol; 2015 Jan; 10(1):269-78. PubMed ID: 25420233
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Delineation of Polypharmacology across the Human Structural Kinome Using a Functional Site Interaction Fingerprint Approach.
    Zhao Z; Xie L; Xie L; Bourne PE
    J Med Chem; 2016 May; 59(9):4326-41. PubMed ID: 26929980
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.