BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

227 related articles for article (PubMed ID: 29247859)

  • 1. Synthesis and biological evaluation of novel 1-(aryl-aldehyde-oxime)uracil derivatives as a new class of thymidine phosphorylase inhibitors.
    Zhao S; Li K; Jin Y; Lin J
    Eur J Med Chem; 2018 Jan; 144():41-51. PubMed ID: 29247859
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase.
    Nencka R; Votruba I; Hrebabecký H; Tloust'ová E; Horská K; Masojídková M; Holý A
    Bioorg Med Chem Lett; 2006 Mar; 16(5):1335-7. PubMed ID: 16337119
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 2: optimization of inhibitors of human thymidine phosphorylase and their selectivity with uridine phosphorylase.
    Yano S; Kazuno H; Sato T; Suzuki N; Emura T; Wierzba K; Yamashita J; Tada Y; Yamada Y; Fukushima M; Asao T
    Bioorg Med Chem; 2004 Jul; 12(13):3443-50. PubMed ID: 15186830
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and enzymatic evaluation of 6-bridged imidazolyluracil derivatives as inhibitors of human thymidine phosphorylase.
    McNally VA; Rajabi M; Gbaj A; Stratford IJ; Edwards PN; Douglas KT; Bryce RA; Jaffar M; Freeman S
    J Pharm Pharmacol; 2007 Apr; 59(4):537-47. PubMed ID: 17430637
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase.
    Corelli F; Botta M; Lossani A; Pasquini S; Spadari S; Focher F
    Farmaco; 2004 Dec; 59(12):987-92. PubMed ID: 15598434
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, thymidine phosphorylase inhibition and molecular modeling studies of 1,3,4-oxadiazole-2-thione derivatives.
    Shahzad SA; Yar M; Bajda M; Shahzadi L; Khan ZA; Naqvi SA; Mutahir S; Mahmood N; Khan KM
    Bioorg Chem; 2015 Jun; 60():37-41. PubMed ID: 25920005
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis, evaluation of thymidine phosphorylase and angiogenic inhibitory potential of ciprofloxacin analogues: Repositioning of ciprofloxacin from antibiotic to future anticancer drugs.
    Shahzad SA; Sarfraz A; Yar M; Khan ZA; Naqvi SAR; Naz S; Khan NA; Farooq U; Batool R; Ali M
    Bioorg Chem; 2020 Jul; 100():103876. PubMed ID: 32388426
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and enzymatic evaluation of pyridinium-substituted uracil derivatives as novel inhibitors of thymidine phosphorylase.
    Murray PE; McNally VA; Lockyer SD; Williams KJ; Stratford IJ; Jaffar M; Freeman S
    Bioorg Med Chem; 2002 Mar; 10(3):525-30. PubMed ID: 11814838
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In silico binding analysis and SAR elucidations of newly designed benzopyrazine analogs as potent inhibitors of thymidine phosphorylase.
    Taha M; Ismail NH; Imran S; Rahim F; Wadood A; Al Muqarrabun LM; Khan KM; Ghufran M; Ali M
    Bioorg Chem; 2016 Oct; 68():80-9. PubMed ID: 27474803
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and in vitro evaluation of 5-fluoro-6-[(2-iminopyrrolidin-1-YL)methyl]uracil, TPI(F): an inhibitor of human thymidine phosphorylase (TP).
    Grierson JR; Brockenbrough JS; Rasey JS; Wiens L; Vesselle H
    Nucleosides Nucleotides Nucleic Acids; 2010 Jan; 29(1):49-54. PubMed ID: 20391192
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis, thymidine phosphorylase, angiogenic inhibition and molecular docking study of isoquinoline derivatives.
    Zaman K; Rahim F; Taha M; Wadood A; Adnan Ali Shah S; Gollapalli M; Ullah F; Ahmed A
    Bioorg Chem; 2019 Aug; 89():102999. PubMed ID: 31151055
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.
    Cole C; Reigan P; Gbaj A; Edwards PN; Douglas KT; Stratford IJ; Freeman S; Jaffar M
    J Med Chem; 2003 Jan; 46(2):207-9. PubMed ID: 12519058
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and biological evaluation of novel oxadiazole derivatives: a new class of thymidine phosphorylase inhibitors as potential anti-tumor agents.
    Shahzad SA; Yar M; Bajda M; Jadoon B; Khan ZA; Naqvi SA; Shaikh AJ; Hayat K; Mahmmod A; Mahmood N; Filipek S
    Bioorg Med Chem; 2014 Feb; 22(3):1008-15. PubMed ID: 24411198
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase.
    Nencka R; Votruba I; Hrebabecký H; Jansa P; Tloust'ová E; Horská K; Masojídková M; Holý A
    J Med Chem; 2007 Nov; 50(24):6016-23. PubMed ID: 17963370
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design, synthesis, in-vitro thymidine phosphorylase inhibition, in-vivo antiangiogenic and in-silico studies of C-6 substituted dihydropyrimidines.
    Iftikhar F; Yaqoob F; Tabassum N; Jan MS; Sadiq A; Tahir S; Batool T; Niaz B; Ansari FL; Choudhary MI; Rashid U
    Bioorg Chem; 2018 Oct; 80():99-111. PubMed ID: 29894893
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis, molecular docking study and in vitro thymidine phosphorylase inhibitory potential of oxadiazole derivatives.
    Ullah H; Rahim F; Taha M; Uddin I; Wadood A; Shah SAA; Farooq RK; Nawaz M; Wahab Z; Khan KM
    Bioorg Chem; 2018 Aug; 78():58-67. PubMed ID: 29533215
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 1: discovery of novel orally active inhibitors of human thymidine phosphorylase.
    Yano S; Kazuno H; Suzuki N; Emura T; Wierzba K; Yamashita J; Tada Y; Yamada Y; Fukushima M; Asao T
    Bioorg Med Chem; 2004 Jul; 12(13):3431-41. PubMed ID: 15186829
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of mixed type thymidine phosphorylase inhibitors endowed with antiangiogenic properties: synthesis, pharmacological evaluation and molecular docking study of 2-thioxo-pyrazolo[1,5-a][1,3,5]triazin-4-ones. Part II.
    Bera H; Ojha Pk; Tan BJ; Sun L; Dolzhenko AV; Chui WK; Chiu GN
    Eur J Med Chem; 2014 May; 78():294-303. PubMed ID: 24686016
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and molecular docking study of piperazine derivatives as potent inhibitor of thymidine phosphorylase.
    Uddin I; Taha M; Rahim F; Wadood A
    Bioorg Chem; 2018 Aug; 78():324-331. PubMed ID: 29626638
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis, SAR elucidations and molecular docking study of newly designed isatin based oxadiazole analogs as potent inhibitors of thymidine phosphorylase.
    Javid MT; Rahim F; Taha M; Nawaz M; Wadood A; Ali M; Mosaddik A; Shah SAA; Farooq RK
    Bioorg Chem; 2018 Sep; 79():323-333. PubMed ID: 29803079
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.