BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

208 related articles for article (PubMed ID: 29248972)

  • 1. Pharmacological targeting of HSP90 with 17-AAG induces apoptosis of myogenic cells through activation of the intrinsic pathway.
    Wagatsuma A; Takayama Y; Hoshino T; Shiozuka M; Yamada S; Matsuda R; Mabuchi K
    Mol Cell Biochem; 2018 Aug; 445(1-2):45-58. PubMed ID: 29248972
    [TBL] [Abstract][Full Text] [Related]  

  • 2. SNX-2112, a novel Hsp90 inhibitor, induces G2/M cell cycle arrest and apoptosis in MCF-7 cells.
    Wang SX; Ju HQ; Liu KS; Zhang JX; Wang X; Xiang YF; Wang R; Liu JY; Liu QY; Xia M; Xing GW; Liu Z; Wang YF
    Biosci Biotechnol Biochem; 2011; 75(8):1540-5. PubMed ID: 21821931
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The HSP90 inhibitor 17-N-allylamino-17-demethoxy geldanamycin (17-AAG) synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines via the Akt/XIAP pathway.
    Ui T; Morishima K; Saito S; Sakuma Y; Fujii H; Hosoya Y; Ishikawa S; Aburatani H; Fukayama M; Niki T; Yasuda Y
    Oncol Rep; 2014 Feb; 31(2):619-24. PubMed ID: 24317439
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cells.
    Premkumar DR; Arnold B; Jane EP; Pollack IF
    Mol Carcinog; 2006 Jan; 45(1):47-59. PubMed ID: 16267832
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Combined effect of Hsp90 inhibitor geldanamycin and parthenolide via reactive oxygen species-mediated apoptotic process on epithelial ovarian cancer cells.
    Lee CS; Kim YJ; Lee SA; Myung SC; Kim W
    Basic Clin Pharmacol Toxicol; 2012 Sep; 111(3):173-81. PubMed ID: 22433057
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of HSP90-dependent telomerase activity in amyloid β-induced apoptosis of cerebral endothelial cells.
    Chiu WT; Shen SC; Yang LY; Chow JM; Wu CY; Chen YC
    J Cell Physiol; 2011 Aug; 226(8):2041-51. PubMed ID: 21520056
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The Hsp90 inhibitor SNX-2112, induces apoptosis in multidrug resistant K562/ADR cells through suppression of Akt/NF-κB and disruption of mitochondria-dependent pathways.
    Wang R; Shao F; Liu Z; Zhang J; Wang S; Liu J; Liu H; Chen H; Liu K; Xia M; Wang Y
    Chem Biol Interact; 2013 Sep; 205(1):1-10. PubMed ID: 23777986
    [TBL] [Abstract][Full Text] [Related]  

  • 8. [Gene Expression Profile of Apoptosis in Leukemia Cells Induced by Hsp90 Selective inhibitor 17-AAG].
    Wang NN; Li ZH; Tao YF; Xu LX; Pan J; Hu SY
    Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2016 Jun; 24(3):672-80. PubMed ID: 27342489
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Anti-apoptotic effect of heat shock protein 90 on hypoxia-mediated cardiomyocyte damage is mediated via the phosphatidylinositol 3-kinase/AKT pathway.
    Wang W; Peng Y; Wang Y; Zhao X; Yuan Z
    Clin Exp Pharmacol Physiol; 2009 Sep; 36(9):899-903. PubMed ID: 19298537
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel C-terminal Hsp90 inhibitor for head and neck squamous cell cancer (HNSCC) with in vivo efficacy and improved toxicity profiles compared with standard agents.
    Cohen SM; Mukerji R; Samadi AK; Zhang X; Zhao H; Blagg BS; Cohen MS
    Ann Surg Oncol; 2012 Jul; 19 Suppl 3(Suppl 3):S483-90. PubMed ID: 21837531
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The role of the Hsp90/Akt pathway in myocardial calpain-induced caspase-3 activation and apoptosis during sepsis.
    Li X; Luo R; Jiang R; Meng X; Wu X; Zhang S; Hua W
    BMC Cardiovasc Disord; 2013 Feb; 13():8. PubMed ID: 23425388
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Apoptosis induction in human leukemic cells by a novel protein Bengalin, isolated from Indian black scorpion venom: through mitochondrial pathway and inhibition of heat shock proteins.
    Gupta SD; Gomes A; Debnath A; Saha A; Gomes A
    Chem Biol Interact; 2010 Jan; 183(2):293-303. PubMed ID: 19913524
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death.
    Georgakis GV; Li Y; Rassidakis GZ; Martinez-Valdez H; Medeiros LJ; Younes A
    Clin Cancer Res; 2006 Jan; 12(2):584-90. PubMed ID: 16428504
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Heat shock pretreatment inhibited the release of Smac/DIABLO from mitochondria and apoptosis induced by hydrogen peroxide in cardiomyocytes and C2C12 myogenic cells.
    Jiang B; Xiao W; Shi Y; Liu M; Xiao X
    Cell Stress Chaperones; 2005; 10(3):252-62. PubMed ID: 16184770
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Targeting PI3K/Akt/HSP90 signaling sensitizes gastric cancer cells to deoxycholate-induced apoptosis.
    Redlak MJ; Miller TA
    Dig Dis Sci; 2011 Feb; 56(2):323-9. PubMed ID: 20585984
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9.
    Georgakis GV; Li Y; Younes A
    Br J Haematol; 2006 Oct; 135(1):68-71. PubMed ID: 16925576
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin.
    Guo F; Rocha K; Bali P; Pranpat M; Fiskus W; Boyapalle S; Kumaraswamy S; Balasis M; Greedy B; Armitage ES; Lawrence N; Bhalla K
    Cancer Res; 2005 Nov; 65(22):10536-44. PubMed ID: 16288046
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation.
    Jeon YK; Park CH; Kim KY; Li YC; Kim J; Kim YA; Paik JH; Park BK; Kim CW; Kim YN
    J Pathol; 2007 Oct; 213(2):170-9. PubMed ID: 17768706
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The HSP90 inhibitor 17-AAG synergizes with doxorubicin and U0126 in anaplastic large cell lymphoma irrespective of ALK expression.
    Georgakis GV; Li Y; Rassidakis GZ; Medeiros LJ; Younes A
    Exp Hematol; 2006 Dec; 34(12):1670-9. PubMed ID: 17157164
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Isoegomaketone induces apoptosis through caspase-dependent and caspase-independent pathways in human DLD1 cells.
    Cho BO; Jin CH; Park YD; Ryu HW; Byun MW; Seo KI; Jeong IY
    Biosci Biotechnol Biochem; 2011; 75(7):1306-11. PubMed ID: 21737934
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.