BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

119 related articles for article (PubMed ID: 29249626)

  • 1. Discovery of novel scaffolds for γ-secretase modulators without an arylimidazole moiety.
    Sekioka R; Honjo E; Honda S; Fuji H; Akashiba H; Mitani Y; Yamasaki S
    Bioorg Med Chem; 2018 Jan; 26(2):435-442. PubMed ID: 29249626
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Optimization and biological evaluation of imidazopyridine derivatives as a novel scaffold for γ-secretase modulators with oral efficacy against cognitive deficits in Alzheimer's disease model mice.
    Sekioka R; Honda S; Akashiba H; Yarimizu J; Mitani Y; Yamasaki S
    Bioorg Med Chem; 2020 Jun; 28(11):115455. PubMed ID: 32307259
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active γ-secretase modulators.
    Sekioka R; Honda S; Honjo E; Suzuki T; Akashiba H; Mitani Y; Yamasaki S
    Bioorg Med Chem; 2020 Jan; 28(1):115132. PubMed ID: 31767402
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators.
    Takai T; Hoashi Y; Tomata Y; Morimoto S; Nakamura M; Watanabe T; Igari T; Koike T
    Bioorg Med Chem Lett; 2015 Oct; 25(19):4245-9. PubMed ID: 26298496
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design and synthesis of piperazine derivatives as a novel class of γ-secretase modulators that selectively lower Aβ₄₂ production.
    Takai T; Koike T; Honda E; Kajita Y; Nakamura M; Morimoto S; Hoashi Y; Kamata M; Watanabe T; Igari T; Terauchi J
    Bioorg Med Chem; 2015 May; 23(9):1923-34. PubMed ID: 25842363
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2).
    Takai T; Koike T; Nakamura M; Kajita Y; Yamashita T; Taya N; Tsukamoto T; Watanabe T; Murakami K; Igari T; Kamata M
    Bioorg Med Chem; 2016 Jul; 24(14):3192-206. PubMed ID: 27255179
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and synthesis of an aminopiperidine series of γ-secretase modulators.
    Kobayashi T; Iwama S; Fusano A; Kato Y; Ikeda A; Teranishi Y; Nishihara A; Tobe M
    Bioorg Med Chem Lett; 2014 Jan; 24(1):378-81. PubMed ID: 24269163
    [TBL] [Abstract][Full Text] [Related]  

  • 8. First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms.
    Borgegard T; Juréus A; Olsson F; Rosqvist S; Sabirsh A; Rotticci D; Paulsen K; Klintenberg R; Yan H; Waldman M; Stromberg K; Nord J; Johansson J; Regner A; Parpal S; Malinowsky D; Radesater AC; Li T; Singh R; Eriksson H; Lundkvist J
    J Biol Chem; 2012 Apr; 287(15):11810-9. PubMed ID: 22334705
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.
    Rynearson KD; Buckle RN; Herr RJ; Mayhew NJ; Chen X; Paquette WD; Sakwa SA; Yang J; Barnes KD; Nguyen P; Mobley WC; Johnson G; Lin JH; Tanzi RE; Wagner SL
    Bioorg Med Chem; 2020 Nov; 28(22):115734. PubMed ID: 33007551
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.
    Wagner SL; Zhang C; Cheng S; Nguyen P; Zhang X; Rynearson KD; Wang R; Li Y; Sisodia SS; Mobley WC; Tanzi RE
    Biochemistry; 2014 Feb; 53(4):702-13. PubMed ID: 24401146
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.
    Zettl H; Ness J; Hähnke V; Beher D; Jumpertz T; Saric A; Baumann K; Pietrzik CU; Bulic B; Schneider G; Weggen S
    ACS Chem Biol; 2012 Sep; 7(9):1488-95. PubMed ID: 22725102
    [TBL] [Abstract][Full Text] [Related]  

  • 12. CTF1-51, a truncated carboxyl-terminal fragment of amyloid precursor protein, suppresses the effects of Aβ42-lowering γ-secretase modulators.
    Watahiki H; Yagishita S; Futai E; Ishiura S
    Neurosci Lett; 2012 Sep; 526(2):96-9. PubMed ID: 22940081
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Orally bioavailable and brain-penetrant pyridazine and pyridine-derived γ-secretase modulators reduced amyloidogenic Aβ peptides in vivo.
    Huang Y; Li T; Eatherton A; Mitchell WL; Rong N; Ye L; Yang XJ; Jin S; Ding Y; Zhang J; Li Y; Wu Y; Jin Y; Sang Y; Cheng Z; Browne ER; Harrison DC; Hussain I; Wan Z; Hall A; Lau LF; Matsuoka Y
    Neuropharmacology; 2013 Jul; 70():278-86. PubMed ID: 23485401
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synergistic inhibition of Aβ production by combinations of γ-secretase modulators.
    Robertson AS; Iben LG; Wei C; Meredith JE; Drexler DM; Banks M; Vite GD; Olson RE; Thompson LA; Albright CF; Ahlijanian MK; Toyn JH
    Eur J Pharmacol; 2017 Oct; 812():104-112. PubMed ID: 28690193
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators.
    Gerlach K; Hobson S; Eickmeier C; Groß U; Braun C; Sieger P; Garneau M; Hoerer S; Heine N
    Bioorg Med Chem; 2018 Jul; 26(12):3227-3241. PubMed ID: 29735425
    [TBL] [Abstract][Full Text] [Related]  

  • 16. γ-Secretase modulator in Alzheimer's disease: shifting the end.
    Xia W; Wong ST; Hanlon E; Morin P
    J Alzheimers Dis; 2012; 31(4):685-96. PubMed ID: 22710916
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design and synthesis of a novel series of bicyclic heterocycles as potent γ-secretase modulators.
    Bischoff F; Berthelot D; De Cleyn M; Macdonald G; Minne G; Oehlrich D; Pieters S; Surkyn M; Trabanco AA; Tresadern G; Van Brandt S; Velter I; Zaja M; Borghys H; Masungi C; Mercken M; Gijsen HJ
    J Med Chem; 2012 Nov; 55(21):9089-106. PubMed ID: 22650177
    [TBL] [Abstract][Full Text] [Related]  

  • 18. BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease.
    Scannevin RH; Chollate S; Brennan MS; Snodgrass-Belt PA; Peng H; Xu L; Jung MY; Bussiere T; Arastu MF; Talreja T; Xin Z; Dunstan RW; Fahrer D; Rohde E; Dunah AW; Wang J; Kumaravel G; Taveras AG; Moore Arnold H; Rhodes KJ
    Neuropharmacology; 2016 Apr; 103():57-68. PubMed ID: 26690893
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme.
    Rynearson KD; Buckle RN; Barnes KD; Herr RJ; Mayhew NJ; Paquette WD; Sakwa SA; Nguyen PD; Johnson G; Tanzi RE; Wagner SL
    Bioorg Med Chem Lett; 2016 Aug; 26(16):3928-37. PubMed ID: 27426299
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production.
    Strömberg K; Eketjäll S; Georgievska B; Tunblad K; Eliason K; Olsson F; Radesäter AC; Klintenberg R; Arvidsson PI; von Berg S; Fälting J; Cowburn RF; Dabrowski M
    FEBS J; 2015 Jan; 282(1):65-73. PubMed ID: 25303711
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.