BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

344 related articles for article (PubMed ID: 29258046)

  • 1. Stability assessment of antibody-drug conjugate Trastuzumab emtansine in comparison to parent monoclonal antibody using orthogonal testing protocol.
    Mohamed HE; Mohamed AA; Al-Ghobashy MA; Fathalla FA; Abbas SS
    J Pharm Biomed Anal; 2018 Feb; 150():268-277. PubMed ID: 29258046
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Affinity profiling of monoclonal antibody and antibody-drug-conjugate preparations by coupled liquid chromatography-surface plasmon resonance biosensing.
    Lakayan D; Haselberg R; Gahoual R; Somsen GW; Kool J
    Anal Bioanal Chem; 2018 Dec; 410(30):7837-7848. PubMed ID: 30328504
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A mechanistic pharmacokinetic model elucidating the disposition of trastuzumab emtansine (T-DM1), an antibody-drug conjugate (ADC) for treatment of metastatic breast cancer.
    Bender B; Leipold DD; Xu K; Shen BQ; Tibbitts J; Friberg LE
    AAPS J; 2014 Sep; 16(5):994-1008. PubMed ID: 24917179
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Evaluation of the pattern and kinetics of degradation of adalimumab using a stability-indicating orthogonal testing protocol.
    Hassan LA; Al-Ghobashy MA; Abbas SS
    Biomed Chromatogr; 2019 Dec; 33(12):e4676. PubMed ID: 31389037
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate.
    Marcoux J; Champion T; Colas O; Wagner-Rousset E; Corvaïa N; Van Dorsselaer A; Beck A; Cianférani S
    Protein Sci; 2015 Aug; 24(8):1210-23. PubMed ID: 25694334
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Biophysical Properties and Heating-Induced Aggregation of Lysine-Conjugated Antibody-Drug Conjugates.
    Gandhi AV; Arlotta KJ; Chen HN; Owen SC; Carpenter JF
    J Pharm Sci; 2018 Jul; 107(7):1858-1869. PubMed ID: 29626535
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Comparative Assessment of the Effect of Hyper-glycosylation on the Pattern and Kinetics of Degradation of Darbepoetin Alfa using a Stability-Indicating Orthogonal Testing Protocol.
    Moenes EM; Al-Ghobashy MA; Mohamed AA; Salem MY
    J Chromatogr B Analyt Technol Biomed Life Sci; 2018 Jan; 1072():405-414. PubMed ID: 29157782
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and evaluation of antibody-drug conjugates with high drug-to-antibody ratio using dimaleimide-DM1 as a linker- payload.
    Jeon JH; Woo Kim S; Kim YJ; Park JW; Eun Moon J; Beom Lee Y; Yu H; Lee GH; Jin SH; Jeong JH
    Bioorg Chem; 2024 Aug; 149():107504. PubMed ID: 38850783
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Stability assessment of Polatuzumab vedotin and Brentuximab vedotin using different analytical techniques.
    Mohamed HE; Al-Ghobashy MA; Abbas SS; Boltia SA
    J Pharm Biomed Anal; 2023 May; 228():115249. PubMed ID: 36827859
    [TBL] [Abstract][Full Text] [Related]  

  • 10. In-depth structural characterization of Kadcyla® (ado-trastuzumab emtansine) and its biosimilar candidate.
    Chen L; Wang L; Shion H; Yu C; Yu YQ; Zhu L; Li M; Chen W; Gao K
    MAbs; 2016 Oct; 8(7):1210-1223. PubMed ID: 27380163
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Improved Tumor Penetration and Single-Cell Targeting of Antibody-Drug Conjugates Increases Anticancer Efficacy and Host Survival.
    Cilliers C; Menezes B; Nessler I; Linderman J; Thurber GM
    Cancer Res; 2018 Feb; 78(3):758-768. PubMed ID: 29217763
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A comprehensive stability assessment of insulin degludec using New customized validated RP-HPLC and SEC-HPLC methods in an orthogonal testing protocol.
    Abdelwaly EA; Mohamed AA; El-Kosasy AM; Ayad MF
    J Pharm Biomed Anal; 2021 Sep; 203():114175. PubMed ID: 34098506
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Ado-trastuzumab Emtansine (T-DM1): an antibody-drug conjugate (ADC) for HER2-positive breast cancer.
    Lambert JM; Chari RV
    J Med Chem; 2014 Aug; 57(16):6949-64. PubMed ID: 24967516
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Correlation between Dynamic Light Scattering and Size Exclusion High Performance Liquid Chromatography for Monitoring the Effect of pH on Stability of Biopharmaceuticals.
    Al-Ghobashy MA; Mostafa MM; Abed HS; Fathalla FA; Salem MY
    J Chromatogr B Analyt Technol Biomed Life Sci; 2017 Aug; 1060():1-9. PubMed ID: 28578190
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Conjugation site analysis of antibody-drug-conjugates (ADCs) by signature ion fingerprinting and normalized area quantitation approach using nano-liquid chromatography coupled to high resolution mass spectrometry.
    Sang H; Lu G; Liu Y; Hu Q; Xing W; Cui D; Zhou F; Zhang J; Hao H; Wang G; Ye H
    Anal Chim Acta; 2017 Feb; 955():67-78. PubMed ID: 28088282
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Physicochemical stability of the antibody-drug conjugate Trastuzumab-DM1: changes due to modification and conjugation processes.
    Wakankar AA; Feeney MB; Rivera J; Chen Y; Kim M; Sharma VK; Wang YJ
    Bioconjug Chem; 2010 Sep; 21(9):1588-95. PubMed ID: 20698491
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Conjugation of Emtansine Onto Trastuzumab Promotes Aggregation of the Antibody-Drug Conjugate by Reducing Repulsive Electrostatic Interactions and Increasing Hydrophobic Interactions.
    Gandhi AV; Randolph TW; Carpenter JF
    J Pharm Sci; 2019 Jun; 108(6):1973-1983. PubMed ID: 30735687
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design.
    Maass KF; Kulkarni C; Betts AM; Wittrup KD
    AAPS J; 2016 May; 18(3):635-46. PubMed ID: 26912181
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer.
    Junutula JR; Flagella KM; Graham RA; Parsons KL; Ha E; Raab H; Bhakta S; Nguyen T; Dugger DL; Li G; Mai E; Lewis Phillips GD; Hiraragi H; Fuji RN; Tibbitts J; Vandlen R; Spencer SD; Scheller RH; Polakis P; Sliwkowski MX
    Clin Cancer Res; 2010 Oct; 16(19):4769-78. PubMed ID: 20805300
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates.
    Ponte JF; Sun X; Yoder NC; Fishkin N; Laleau R; Coccia J; Lanieri L; Bogalhas M; Wang L; Wilhelm S; Widdison W; Pinkas J; Keating TA; Chari R; Erickson HK; Lambert JM
    Bioconjug Chem; 2016 Jul; 27(7):1588-98. PubMed ID: 27174129
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.