These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

117 related articles for article (PubMed ID: 29259758)

  • 21. Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist.
    Negoro N; Sasaki S; Mikami S; Ito M; Suzuki M; Tsujihata Y; Ito R; Harada A; Takeuchi K; Suzuki N; Miyazaki J; Santou T; Odani T; Kanzaki N; Funami M; Tanaka T; Kogame A; Matsunaga S; Yasuma T; Momose Y
    ACS Med Chem Lett; 2010 Sep; 1(6):290-4. PubMed ID: 24900210
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold.
    Li H; Huang Q; Chen C; Xu B; Wang HY; Long YQ
    J Med Chem; 2017 Apr; 60(7):2697-2717. PubMed ID: 28277660
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Structural basis for the agonist action at free fatty acid receptor 1 (FFA1R or GPR40).
    Rodrigues DA; Pinheiro PSM; Ferreira TTDSC; Thota S; Fraga CAM
    Chem Biol Drug Des; 2018 Mar; 91(3):668-680. PubMed ID: 29068547
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Long-term in vitro treatment of INS-1 rat pancreatic β-cells by unsaturated free fatty acids protects cells against gluco- and lipotoxicities via activation of GPR40 receptors.
    Tuo Y; Feng DD; Wang DF; Sun J; Li SB; Chen C
    Clin Exp Pharmacol Physiol; 2012 May; 39(5):423-8. PubMed ID: 22332921
    [TBL] [Abstract][Full Text] [Related]  

  • 25. GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space.
    Chen C; Li H; Long YQ
    Bioorg Med Chem Lett; 2016 Dec; 26(23):5603-5612. PubMed ID: 27825762
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Evidence for the involvement of GPR40 and NADPH oxidase in palmitic acid-induced superoxide production and insulin secretion.
    Graciano MF; Valle MM; Curi R; Carpinelli AR
    Islets; 2013; 5(4):139-48. PubMed ID: 23817296
    [TBL] [Abstract][Full Text] [Related]  

  • 27. GPR40 protein levels are crucial to the regulation of stimulated hormone secretion in pancreatic islets. Lessons from spontaneous obesity-prone and non-obese type 2 diabetes in rats.
    Meidute Abaraviciene S; Muhammed SJ; Amisten S; Lundquist I; Salehi A
    Mol Cell Endocrinol; 2013 Dec; 381(1-2):150-9. PubMed ID: 23911664
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Identification of fused-ring alkanoic acids with improved pharmacokinetic profiles that act as G protein-coupled receptor 40/free fatty acid receptor 1 agonists.
    Negoro N; Sasaki S; Ito M; Kitamura S; Tsujihata Y; Ito R; Suzuki M; Takeuchi K; Suzuki N; Miyazaki J; Santou T; Odani T; Kanzaki N; Funami M; Tanaka T; Yasuma T; Momose Y
    J Med Chem; 2012 Feb; 55(4):1538-52. PubMed ID: 22242551
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Recent Advances in Development of GPR40 Modulators (FFA1/FFAR1): An Emerging Target for Type 2 Diabetes.
    Sharma N; Bhagat S; Chundawat TS
    Mini Rev Med Chem; 2017; 17(11):947-958. PubMed ID: 28117025
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion.
    Salehi A; Flodgren E; Nilsson NE; Jimenez-Feltstrom J; Miyazaki J; Owman C; Olde B
    Cell Tissue Res; 2005 Nov; 322(2):207-15. PubMed ID: 16044321
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion.
    Tomita T; Masuzaki H; Iwakura H; Fujikura J; Noguchi M; Tanaka T; Ebihara K; Kawamura J; Komoto I; Kawaguchi Y; Fujimoto K; Doi R; Shimada Y; Hosoda K; Imamura M; Nakao K
    Diabetologia; 2006 May; 49(5):962-8. PubMed ID: 16525841
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Discovery of novel benzo[b]thiophene tetrazoles as non-carboxylate GPR40 agonists.
    Huang H; Winters MP; Meegalla SK; Arnoult E; Paul Lee S; Zhao S; Martin T; Rady B; Liu J; Towers M; Otieno M; Xu F; Lim HK; Silva J; Pocai A; Player MR
    Bioorg Med Chem Lett; 2018 Feb; 28(3):429-436. PubMed ID: 29258772
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Discovery of 3-aryl-3-ethoxypropanoic acids as orally active GPR40 agonists.
    Takano R; Yoshida M; Inoue M; Honda T; Nakashima R; Matsumoto K; Yano T; Ogata T; Watanabe N; Toda N
    Bioorg Med Chem Lett; 2014 Jul; 24(13):2949-53. PubMed ID: 24835985
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet beta-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release.
    Fujiwara K; Maekawa F; Yada T
    Am J Physiol Endocrinol Metab; 2005 Oct; 289(4):E670-7. PubMed ID: 15914509
    [TBL] [Abstract][Full Text] [Related]  

  • 35. GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production.
    Miller C; Pachanski MJ; Kirkland ME; Kosinski DT; Mane J; Bunzel M; Cao J; Souza S; Thomas-Fowlkes B; Di Salvo J; Weinglass AB; Li X; Myers RW; Knagge K; Carrington PE; Hagmann WK; Trujillo ME
    PLoS One; 2017; 12(5):e0176182. PubMed ID: 28542610
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice.
    Du T; Yang L; Xu X; Shi X; Xu X; Lu J; Lv J; Huang X; Chen J; Wang H; Ye J; Hu L; Shen X
    J Endocrinol; 2019 Feb; 240(2):195-214. PubMed ID: 30400036
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Suppression of free fatty acid receptor 1 expression in pancreatic β-cells in obese type 2 diabetic db/db mice: a potential role of pancreatic and duodenal homeobox factor 1.
    Kohara K; Obata A; Kimura T; Shimoda M; Moriuchi S; Okauchi S; Hirukawa H; Mune T; Kaku K; Kaneto H
    Endocr J; 2019 Jan; 66(1):43-50. PubMed ID: 30333365
    [TBL] [Abstract][Full Text] [Related]  

  • 38. 3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists.
    Walsh SP; Severino A; Zhou C; He J; Liang GB; Tan CP; Cao J; Eiermann GJ; Xu L; Salituro G; Howard AD; Mills SG; Yang L
    Bioorg Med Chem Lett; 2011 Jun; 21(11):3390-4. PubMed ID: 21514824
    [TBL] [Abstract][Full Text] [Related]  

  • 39. GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve.
    Ueno H; Ito R; Abe SI; Ogino H; Maruyama M; Miyashita H; Miyamoto Y; Moritoh Y; Tsujihata Y; Takeuchi K; Nishigaki N
    PLoS One; 2019; 14(9):e0222653. PubMed ID: 31525244
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Novel agonists of free fatty acid receptor 1 (GPR40) based on 3-(1,3,4-thiadiazol-2-yl)propanoic acid scaffold.
    Krasavin M; Lukin A; Zhurilo N; Kovalenko A; Zahanich I; Zozulya S
    J Enzyme Inhib Med Chem; 2016 Dec; 31(6):1404-10. PubMed ID: 26899762
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 6.