BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

765 related articles for article (PubMed ID: 29269047)

  • 1. Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance.
    Sajan MP; Lee MC; Foufelle F; Sajan J; Cleland C; Farese RV
    Cell Signal; 2018 Mar; 43():62-70. PubMed ID: 29269047
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.
    Sajan MP; Ivey RA; Lee MC; Farese RV
    J Lipid Res; 2015 Jan; 56(1):70-80. PubMed ID: 25395359
    [TBL] [Abstract][Full Text] [Related]  

  • 3. BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans.
    Sajan MP; Ivey RA; Farese RV
    Metabolism; 2015 Nov; 64(11):1454-65. PubMed ID: 26386696
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Akt-dependent phosphorylation of hepatic FoxO1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity.
    Sajan MP; Acevedo-Duncan ME; Standaert ML; Ivey RA; Lee M; Farese RV
    Diabetes; 2014 Aug; 63(8):2690-701. PubMed ID: 24705403
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development.
    Sajan M; Hansen B; Ivey R; Sajan J; Ari C; Song S; Braun U; Leitges M; Farese-Higgs M; Farese RV
    Diabetes; 2016 Jul; 65(7):1892-903. PubMed ID: 26895791
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity.
    Sajan MP; Standaert ML; Nimal S; Varanasi U; Pastoor T; Mastorides S; Braun U; Leitges M; Farese RV
    J Lipid Res; 2009 Jun; 50(6):1133-45. PubMed ID: 19202134
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells.
    Gu L; Ding X; Wang Y; Gu M; Zhang J; Yan S; Li N; Song Z; Yin J; Lu L; Peng Y
    Int J Biol Sci; 2019; 15(13):2815-2829. PubMed ID: 31853220
    [No Abstract]   [Full Text] [Related]  

  • 8. Baicalin ameliorates hepatic insulin resistance and gluconeogenic activity through inhibition of p38 MAPK/PGC-1α pathway.
    Fang P; Sun Y; Gu X; Shi M; Bo P; Zhang Z; Bu L
    Phytomedicine; 2019 Nov; 64():153074. PubMed ID: 31473580
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver.
    Hörbelt T; Knebel B; Fahlbusch P; Barbosa D; de Wiza DH; Van de Velde F; Van Nieuwenhove Y; Lapauw B; Thoresen GH; Al-Hasani H; Müller-Wieland D; Ouwens DM; Kotzka J
    Biochim Biophys Acta Mol Basis Dis; 2019 Oct; 1865(10):2671-2684. PubMed ID: 31336149
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c.
    Ponugoti B; Fang S; Kemper JK
    Mol Endocrinol; 2007 Nov; 21(11):2698-712. PubMed ID: 17636037
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Endurance exercise training increases APPL1 expression and improves insulin signaling in the hepatic tissue of diet-induced obese mice, independently of weight loss.
    Marinho R; Ropelle ER; Cintra DE; De Souza CT; Da Silva AS; Bertoli FC; Colantonio E; D'Almeida V; Pauli JR
    J Cell Physiol; 2012 Jul; 227(7):2917-26. PubMed ID: 21938726
    [TBL] [Abstract][Full Text] [Related]  

  • 12. PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.
    Sajan MP; Ivey RA; Lee M; Mastorides S; Jurczak MJ; Samuels VT; Shulman GI; Braun U; Leitges M; Farese RV
    Mol Endocrinol; 2014 Jul; 28(7):1097-107. PubMed ID: 24877563
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance.
    Sajan MP; Standaert ML; Rivas J; Miura A; Kanoh Y; Soto J; Taniguchi CM; Kahn CR; Farese RV
    Diabetologia; 2009 Jun; 52(6):1197-207. PubMed ID: 19357831
    [TBL] [Abstract][Full Text] [Related]  

  • 14. PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism.
    Lee J; Salazar Hernández MA; Auen T; Mucka P; Lee J; Ozcan U
    Mol Metab; 2018 Jan; 7():119-131. PubMed ID: 29129613
    [TBL] [Abstract][Full Text] [Related]  

  • 15. PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle.
    Southgate RJ; Bruce CR; Carey AL; Steinberg GR; Walder K; Monks R; Watt MJ; Hawley JA; Birnbaum MJ; Febbraio MA
    FASEB J; 2005 Dec; 19(14):2072-4. PubMed ID: 16203862
    [TBL] [Abstract][Full Text] [Related]  

  • 16. ALAS1 gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FOXO1 by vanadate in diabetic mice.
    Oliveri LM; Davio C; Batlle AM; Gerez EN
    Biochem J; 2012 Mar; 442(2):303-10. PubMed ID: 22070747
    [TBL] [Abstract][Full Text] [Related]  

  • 17. IGF-II-mediated downregulation of peroxisome proliferator-activated receptor-γ coactivator-1α in myoblast cells involves PI3K/Akt/FoxO1 signaling pathway.
    Mu X; Qi W; Liu Y; Zhou J; Li Y; Rong X; Lu L
    Mol Cell Biochem; 2017 Aug; 432(1-2):199-208. PubMed ID: 28374141
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.
    Puigserver P; Rhee J; Donovan J; Walkey CJ; Yoon JC; Oriente F; Kitamura Y; Altomonte J; Dong H; Accili D; Spiegelman BM
    Nature; 2003 May; 423(6939):550-5. PubMed ID: 12754525
    [TBL] [Abstract][Full Text] [Related]  

  • 19. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression.
    Zhang W; Patil S; Chauhan B; Guo S; Powell DR; Le J; Klotsas A; Matika R; Xiao X; Franks R; Heidenreich KA; Sajan MP; Farese RV; Stolz DB; Tso P; Koo SH; Montminy M; Unterman TG
    J Biol Chem; 2006 Apr; 281(15):10105-17. PubMed ID: 16492665
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression.
    Sajan MP; Ivey RA; Farese RV
    Diabetologia; 2013 Nov; 56(11):2507-16. PubMed ID: 23933835
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 39.