203 related articles for article (PubMed ID: 29271116)
1. A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases.
Pöhler R; Krahn JH; van den Boom J; Dobrynin G; Kaschani F; Eggenweiler HM; Zenke FT; Kaiser M; Meyer H
Angew Chem Int Ed Engl; 2018 Feb; 57(6):1576-1580. PubMed ID: 29271116
[TBL] [Abstract][Full Text] [Related]
2. Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry.
Jones NH; Liu Q; Urnavicius L; Dahan NE; Vostal LE; Kapoor TM
Proc Natl Acad Sci U S A; 2024 Jun; 121(24):e2316892121. PubMed ID: 38833472
[TBL] [Abstract][Full Text] [Related]
3. D1 ring is stable and nucleotide-independent, whereas D2 ring undergoes major conformational changes during the ATPase cycle of p97-VCP.
Wang Q; Song C; Yang X; Li CC
J Biol Chem; 2003 Aug; 278(35):32784-93. PubMed ID: 12807884
[TBL] [Abstract][Full Text] [Related]
4. A structure- and chemical genomics-based approach for repositioning of drugs against VCP/p97 ATPase.
Segura-Cabrera A; Tripathi R; Zhang X; Gui L; Chou TF; Komurov K
Sci Rep; 2017 Mar; 7():44912. PubMed ID: 28322292
[TBL] [Abstract][Full Text] [Related]
5. Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases.
Han H; Fulcher JM; Dandey VP; Iwasa JH; Sundquist WI; Kay MS; Shen PS; Hill CP
Elife; 2019 Jun; 8():. PubMed ID: 31184588
[TBL] [Abstract][Full Text] [Related]
6. Interaction between the AAA
Rao MV; Williams DR; Cocklin S; Loll PJ
J Biol Chem; 2017 Nov; 292(45):18392-18407. PubMed ID: 28939772
[TBL] [Abstract][Full Text] [Related]
7. VCP/p97/Cdc48, A Linking of Protein Homeostasis and Cancer Therapy.
Lan B; Chai S; Wang P; Wang K
Curr Mol Med; 2017; 17(9):608-618. PubMed ID: 29521227
[TBL] [Abstract][Full Text] [Related]
8. AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
Caffrey B; Zhu X; Berezuk A; Tuttle K; Chittori S; Subramaniam S
J Biol Chem; 2021 Oct; 297(4):101187. PubMed ID: 34520757
[TBL] [Abstract][Full Text] [Related]
9. Structure and mechanism of the ESCRT pathway AAA+ ATPase Vps4.
Han H; Hill CP
Biochem Soc Trans; 2019 Feb; 47(1):37-45. PubMed ID: 30647138
[TBL] [Abstract][Full Text] [Related]
10. Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN.
Kröning A; van den Boom J; Kracht M; Kueck AF; Meyer H
J Biol Chem; 2022 Jun; 298(6):101976. PubMed ID: 35469923
[TBL] [Abstract][Full Text] [Related]
11. Allosteric activation of VCP, a AAA unfoldase, by small molecule mimicry.
Jones NH; Liu Q; Urnavicius L; Dahan NE; Vostal LE; Kapoor TM
bioRxiv; 2023 Oct; ():. PubMed ID: 37873168
[TBL] [Abstract][Full Text] [Related]
12. ATP-binding sites in brain p97/VCP (valosin-containing protein), a multifunctional AAA ATPase.
Zalk R; Shoshan-Barmatz V
Biochem J; 2003 Sep; 374(Pt 2):473-80. PubMed ID: 12747802
[TBL] [Abstract][Full Text] [Related]
13. Molecular Mechanisms Driving and Regulating the AAA+ ATPase VCP/p97, an Important Therapeutic Target for Treating Cancer, Neurological and Infectious Diseases.
Valimehr S; Sethi A; Shukla M; Bhattacharyya S; Kazemi M; Rouiller I
Biomolecules; 2023 Apr; 13(5):. PubMed ID: 37238606
[TBL] [Abstract][Full Text] [Related]
14. Adapted ATPase domain communication overcomes the cytotoxicity of p97 inhibitors.
Wei Y; Toth JI; Blanco GA; Bobkov AA; Petroski MD
J Biol Chem; 2018 Dec; 293(52):20169-20180. PubMed ID: 30381397
[TBL] [Abstract][Full Text] [Related]
15. Discovery of a new class of valosine containing protein (VCP/P97) inhibitors for the treatment of non-small cell lung cancer.
Wang X; Bai E; Zhou H; Sha S; Miao H; Qin Y; Liu Z; Wang J; Zhang H; Lei M; Liu J; Hai O; Zhu Y
Bioorg Med Chem; 2019 Feb; 27(3):533-544. PubMed ID: 30606672
[TBL] [Abstract][Full Text] [Related]
16. The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Braxton JR; Altobelli CR; Tucker MR; Tse E; Thwin AC; Arkin MR; Southworth DR
Nat Struct Mol Biol; 2023 Dec; 30(12):2009-2019. PubMed ID: 37945741
[TBL] [Abstract][Full Text] [Related]
17. The human AAA-ATPase VPS4A isoform and its co-factor VTA1 have a unique function in regulating mammalian cytokinesis abscission.
Dvilansky I; Altaras Y; Kamenetsky N; Nachmias D; Elia N
PLoS Biol; 2024 Apr; 22(4):e3002327. PubMed ID: 38687820
[TBL] [Abstract][Full Text] [Related]
18. Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D.
Petrović S; Roske Y; Rami B; Phan MHQ; Panáková D; Heinemann U
Proc Natl Acad Sci U S A; 2023 Jan; 120(4):e2208941120. PubMed ID: 36656859
[TBL] [Abstract][Full Text] [Related]
19. Structural basis of ubiquitin-independent PP1 complex disassembly by p97.
van den Boom J; Marini G; Meyer H; Saibil HR
EMBO J; 2023 Jul; 42(14):e113110. PubMed ID: 37264685
[TBL] [Abstract][Full Text] [Related]
20. Hexamerization of p97-VCP is promoted by ATP binding to the D1 domain and required for ATPase and biological activities.
Wang Q; Song C; Li CC
Biochem Biophys Res Commun; 2003 Jan; 300(2):253-60. PubMed ID: 12504076
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]