These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

138 related articles for article (PubMed ID: 29292229)

  • 1. Discovery of selective, orally bioavailable inhibitor of mouse chitotriosidase.
    Mazur M; Bartoszewicz A; Dymek B; Salamon M; Andryianau G; Kowalski M; Olejniczak S; Matyszewski K; Pluta E; Borek B; Stefaniak F; Zagozdzon A; Mazurkiewicz M; Koralewski R; Czestkowski W; Piotrowicz M; Niedziejko P; Gruza MM; Dzwonek K; Golebiowski A; Golab J; Olczak J
    Bioorg Med Chem Lett; 2018 Feb; 28(3):310-314. PubMed ID: 29292229
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of novel orally bioavailable GPR40 agonists.
    Lu H; Fei H; Yang F; Zheng S; Hu Q; Zhang L; Yuan J; Feng J; Sun P; Dong Q
    Bioorg Med Chem Lett; 2013 May; 23(10):2920-4. PubMed ID: 23582779
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3).
    Chen H; Yang Z; Ding C; Xiong A; Wild C; Wang L; Ye N; Cai G; Flores RM; Ding Y; Shen Q; Zhou J
    Eur J Med Chem; 2014 Jul; 82():195-203. PubMed ID: 24904966
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2.
    Ren L; Grina J; Moreno D; Blake JF; Gaudino JJ; Garrey R; Metcalf AT; Burkard M; Martinson M; Rasor K; Chen H; Dean B; Gould SE; Pacheco P; Shahidi-Latham S; Yin J; West K; Wang W; Moffat JG; Schwarz JB
    J Med Chem; 2015 Feb; 58(4):1976-91. PubMed ID: 25603482
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.
    Mallinger A; Schiemann K; Rink C; Stieber F; Calderini M; Crumpler S; Stubbs M; Adeniji-Popoola O; Poeschke O; Busch M; Czodrowski P; Musil D; Schwarz D; Ortiz-Ruiz MJ; Schneider R; Thai C; Valenti M; de Haven Brandon A; Burke R; Workman P; Dale T; Wienke D; Clarke PA; Esdar C; Raynaud FI; Eccles SA; Rohdich F; Blagg J
    J Med Chem; 2016 Feb; 59(3):1078-101. PubMed ID: 26796641
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors.
    Patel D; Jain M; Shah SR; Bahekar R; Jadav P; Joharapurkar A; Dhanesha N; Shaikh M; Sairam KV; Kapadnis P
    Bioorg Med Chem Lett; 2012 Jan; 22(2):1111-7. PubMed ID: 22189136
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.
    Mallinger A; Crumpler S; Pichowicz M; Waalboer D; Stubbs M; Adeniji-Popoola O; Wood B; Smith E; Thai C; Henley AT; Georgi K; Court W; Hobbs S; Box G; Ortiz-Ruiz MJ; Valenti M; De Haven Brandon A; TePoele R; Leuthner B; Workman P; Aherne W; Poeschke O; Dale T; Wienke D; Esdar C; Rohdich F; Raynaud F; Clarke PA; Eccles SA; Stieber F; Schiemann K; Blagg J
    J Med Chem; 2015 Feb; 58(4):1717-35. PubMed ID: 25680029
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations.
    Zhu K; Jiang C; Tao H; Liu J; Zhang H; Luo C
    Bioorg Med Chem Lett; 2018 May; 28(9):1476-1483. PubMed ID: 29628326
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular cloning and functional characterization of mouse chitotriosidase.
    Zheng T; Rabach M; Chen NY; Rabach L; Hu X; Elias JA; Zhu Z
    Gene; 2005 Aug; 357(1):37-46. PubMed ID: 16005164
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators.
    Nishiguchi G; Keramatnia F; Min J; Chang Y; Jonchere B; Das S; Actis M; Price J; Chepyala D; Young B; McGowan K; Slavish PJ; Mayasundari A; Jarusiewicz JA; Yang L; Li Y; Fu X; Garrett SH; Papizan JB; Kodali K; Peng J; Pruett Miller SM; Roussel MF; Mullighan C; Fischer M; Rankovic Z
    J Med Chem; 2021 Jun; 64(11):7296-7311. PubMed ID: 34042448
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK.
    Laufer R; Li SW; Liu Y; Ng G; Lang Y; Feher M; Brokx R; Beletskaya I; Hodgson R; Mao G; Plotnikova O; Awrey DE; Mason JM; Wei X; Lin DC; Che Y; Kiarash R; Madeira B; Fletcher GC; Mak TW; Bray MR; Pauls HW
    Bioorg Med Chem Lett; 2016 Aug; 26(15):3562-6. PubMed ID: 27335255
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification and characterization of benzo[d]oxazol-2(3H)-one derivatives as the first potent and selective small-molecule inhibitors of chromodomain protein CDYL.
    Yang L; Liu Y; Fan M; Zhu G; Jin H; Liang J; Liu Z; Huang Z; Zhang L
    Eur J Med Chem; 2019 Nov; 182():111656. PubMed ID: 31494467
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors.
    Fu Y; Tang S; Su Y; Lan X; Ye Y; Zha C; Li L; Cao J; Chen Y; Jiang L; Huang Y; Ding J; Geng M; Huang M; Wan H
    Bioorg Med Chem Lett; 2017 Dec; 27(23):5332-5336. PubMed ID: 29074254
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors.
    Barlaam B; Cosulich S; Fitzek M; Germain H; Green S; Hanson LL; Harris CS; Hancox U; Hudson K; Lambert-van der Brempt C; Lamorlette M; Magnien F; Ouvry G; Page K; Ruston L; Ward L; Delouvrié B
    Bioorg Med Chem Lett; 2017 Jul; 27(13):3030-3035. PubMed ID: 28526367
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of selective and orally bioavailable protein kinase Cθ (PKCθ) inhibitors from a fragment hit.
    George DM; Breinlinger EC; Friedman M; Zhang Y; Wang J; Argiriadi M; Bansal-Pakala P; Barth M; Duignan DB; Honore P; Lang Q; Mittelstadt S; Potin D; Rundell L; Edmunds JJ
    J Med Chem; 2015 Jan; 58(1):222-36. PubMed ID: 25000588
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists.
    Emert-Sedlak LA; Loughran HM; Shi H; Kulp JL; Shu ST; Zhao J; Day BW; Wrobel JE; Reitz AB; Smithgall TE
    Bioorg Med Chem Lett; 2016 Mar; 26(5):1480-1484. PubMed ID: 26852364
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor.
    Mori M; Moraca F; Deodato D; Ferraris DM; Selchow P; Sander P; Rizzi M; Botta M
    Bioorg Med Chem Lett; 2014 Jun; 24(11):2508-11. PubMed ID: 24767848
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors.
    Hua Z; Bregman H; Buchanan JL; Chakka N; Guzman-Perez A; Gunaydin H; Huang X; Gu Y; Berry V; Liu J; Teffera Y; Huang L; Egge B; Emkey R; Mullady EL; Schneider S; Andrews PS; Acquaviva L; Dovey J; Mishra A; Newcomb J; Saffran D; Serafino R; Strathdee CA; Turci SM; Stanton M; Wilson C; Dimauro EF
    J Med Chem; 2013 Dec; 56(24):10003-15. PubMed ID: 24294969
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.
    Ozhathil LC; Delalande C; Bianchi B; Nemeth G; Kappel S; Thomet U; Ross-Kaschitza D; Simonin C; Rubin M; Gertsch J; Lochner M; Peinelt C; Reymond JL; Abriel H
    Br J Pharmacol; 2018 Jun; 175(12):2504-2519. PubMed ID: 29579323
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors.
    Nagao S; Yamane Y; Funasaka S; Tanaka K; Miyazaki K; Kotake Y; Kamata J; Watanabe-Miyano S; Toyama O; Ozawa Y; Mizui Y; Okamoto K; Ito D
    Bioorg Med Chem; 2014 Oct; 22(19):5513-29. PubMed ID: 25139751
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.