BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

177 related articles for article (PubMed ID: 29327456)

  • 21. Increasing human Th17 differentiation through activation of orphan nuclear receptor retinoid acid-related orphan receptor γ (RORγ) by a class of aryl amide compounds.
    Zhang W; Zhang J; Fang L; Zhou L; Wang S; Xiang Z; Li Y; Wisely B; Zhang G; An G; Wang Y; Leung S; Zhong Z
    Mol Pharmacol; 2012 Oct; 82(4):583-90. PubMed ID: 22700697
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand.
    Marcotte DJ; Liu Y; Little K; Jones JH; Powell NA; Wildes CP; Silvian LF; Chodaparambil JV
    BMC Struct Biol; 2016 Jun; 16(1):7. PubMed ID: 27246200
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Discovery of biaryls as RORγ inverse agonists by using structure-based design.
    Enyedy IJ; Powell NA; Caravella J; van Vloten K; Chao J; Banerjee D; Marcotte D; Silvian L; McKenzie A; Hong VS; Fontenot JD
    Bioorg Med Chem Lett; 2016 May; 26(10):2459-2463. PubMed ID: 27080181
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo.
    Skepner J; Ramesh R; Trocha M; Schmidt D; Baloglu E; Lobera M; Carlson T; Hill J; Orband-Miller LA; Barnes A; Boudjelal M; Sundrud M; Ghosh S; Yang J
    J Immunol; 2014 Mar; 192(6):2564-75. PubMed ID: 24516202
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Discovery of 2H-chromone-4-one based sulfonamide derivatives as potent retinoic acid receptor-related orphan receptor γt inverse agonists.
    Chen L; Su M; Wu XZ; Wang DZ; Kang YY; Wang CG; Assani I; Wang MX; Zhao SF; Lv SM; Wang JW; Sun B; Li Y; Jin Q; Huang RZ; Liao ZX
    Eur J Med Chem; 2022 Feb; 229():114065. PubMed ID: 34971876
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Identification of tertiary sulfonamides as RORc inverse agonists.
    Fauber BP; René O; Burton B; Everett C; Gobbi A; Hawkins J; Johnson AR; Liimatta M; Lockey P; Norman M; Wong H
    Bioorg Med Chem Lett; 2014 May; 24(9):2182-7. PubMed ID: 24685544
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Withasteroid B from D. metel L. regulates immune responses by modulating the JAK/STAT pathway and the IL-17
    Su Y; Wang Q; Yang B; Wu L; Cheng G; Kuang H
    Clin Exp Immunol; 2017 Oct; 190(1):40-53. PubMed ID: 28617942
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Discovery of N-(2-benzyl-4-oxochroman-7-yl)-2-(5-(ethylsulfonyl) pyridin-2-yl) acetamide (b12) as a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist.
    Chen L; Su M; Jin Q; Wang CG; Assani I; Wang MX; Zhao SF; Lv SM; Wang JW; Sun B; Li Y; Liao ZX
    Bioorg Chem; 2022 Feb; 119():105483. PubMed ID: 34906860
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer.
    Zhang Y; Wu X; Xue X; Li C; Wang J; Wang R; Zhang C; Wang C; Shi Y; Zou L; Li Q; Huang Z; Hao X; Loomes K; Wu D; Chen HW; Xu J; Xu Y
    J Med Chem; 2019 May; 62(9):4716-4730. PubMed ID: 30964293
    [TBL] [Abstract][Full Text] [Related]  

  • 30. (Inverse) Agonists of Retinoic Acid-Related Orphan Receptor γ: Regulation of Immune Responses, Inflammation, and Autoimmune Disease.
    Jetten AM; Cook DN
    Annu Rev Pharmacol Toxicol; 2020 Jan; 60():371-390. PubMed ID: 31386594
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design.
    Narjes F; Xue Y; von Berg S; Malmberg J; Llinas A; Olsson RI; Jirholt J; Grindebacke H; Leffler A; Hossain N; Lepistö M; Thunberg L; Leek H; Aagaard A; McPheat J; Hansson EL; Bäck E; Tångefjord S; Chen R; Xiong Y; Hongbin G; Hansson TG
    J Med Chem; 2018 Sep; 61(17):7796-7813. PubMed ID: 30095900
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Discovery of biaryl carboxylamides as potent RORγ inverse agonists.
    Chao J; Enyedy I; Van Vloten K; Marcotte D; Guertin K; Hutchings R; Powell N; Jones H; Bohnert T; Peng CC; Silvian L; Hong VS; Little K; Banerjee D; Peng L; Taveras A; Viney JL; Fontenot J
    Bioorg Med Chem Lett; 2015 Aug; 25(15):2991-7. PubMed ID: 26048806
    [TBL] [Abstract][Full Text] [Related]  

  • 33. RORγ antagonists and inverse agonists: a patent review.
    Bronner SM; Zbieg JR; Crawford JJ
    Expert Opin Ther Pat; 2017 Jan; 27(1):101-112. PubMed ID: 27629281
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Discovery and pharmacological evaluation of indole derivatives as potent and selective RORγt inverse agonist for multiple autoimmune conditions.
    Shaikh NS; Iyer JP; Munot YS; Mukhopadhyay PP; Raje AA; Nagaraj R; Jamdar V; Gavhane R; Lohote M; Sherkar P; Bala M; Petla R; Meru A; Umrani D; Rouduri S; Joshi S; Reddy S; Kandikere V; Bhuniya D; Kulkarni B; Mookhtiar KA
    Bioorg Med Chem Lett; 2019 Aug; 29(16):2208-2217. PubMed ID: 31272795
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.
    Fauber BP; de Leon Boenig G; Burton B; Eidenschenk C; Everett C; Gobbi A; Hymowitz SG; Johnson AR; Liimatta M; Lockey P; Norman M; Ouyang W; René O; Wong H
    Bioorg Med Chem Lett; 2013 Dec; 23(24):6604-9. PubMed ID: 24239186
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent RORγt inverse agonists.
    Wang Y; Yang T; Liu Q; Ma Y; Yang L; Zhou L; Xiang Z; Cheng Z; Lu S; Orband-Miller LA; Zhang W; Wu Q; Zhang K; Li Y; Xiang JN; Elliott JD; Leung S; Ren F; Lin X
    Bioorg Med Chem; 2015 Sep; 23(17):5293-302. PubMed ID: 26277758
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin.
    Bovenschen HJ; van de Kerkhof PC; van Erp PE; Woestenenk R; Joosten I; Koenen HJ
    J Invest Dermatol; 2011 Sep; 131(9):1853-60. PubMed ID: 21654831
    [TBL] [Abstract][Full Text] [Related]  

  • 38. A reversed sulfonamide series of selective RORc inverse agonists.
    van Niel MB; Fauber BP; Cartwright M; Gaines S; Killen JC; René O; Ward SI; de Leon Boenig G; Deng Y; Eidenschenk C; Everett C; Gancia E; Ganguli A; Gobbi A; Hawkins J; Johnson AR; Kiefer JR; La H; Lockey P; Norman M; Ouyang W; Qin A; Wakes N; Waszkowycz B; Wong H
    Bioorg Med Chem Lett; 2014 Dec; 24(24):5769-5776. PubMed ID: 25453817
    [TBL] [Abstract][Full Text] [Related]  

  • 39. A novel RORγt inhibitor is a potential therapeutic agent for the topical treatment of psoriasis with low risk of thymic aberrations.
    Imura C; Ueyama A; Sasaki Y; Shimizu M; Furue Y; Tai N; Tsujii K; Katayama K; Okuno T; Shichijo M; Yasui K; Yamamoto M
    J Dermatol Sci; 2019 Mar; 93(3):176-185. PubMed ID: 30905492
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Discovery of N-indanyl benzamides as potent RORγt inverse agonists.
    Tian J; Sun N; Yu M; Gu X; Xie Q; Shao L; Liu J; Liu L; Wang Y
    Eur J Med Chem; 2019 Apr; 167():37-48. PubMed ID: 30743096
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.